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Research project examines unfamiliar space to make it 'older person-friendly'

Urban planning needs to consider how older people use walking routes as well as public areas, concludes a Research Council UK-funded research project from the New Dynamics of Ageing Programme.

17 Dec 2010

Gene variant affects brain function long before brain begins accumulating amyloid: Study

People with a known, high risk for Alzheimer's disease develop abnormal brain function even before the appearance of telltale amyloid plaques that are characteristic of the disease, according to a new study.

17 Dec 2010

City Tech Nursing Professor provides community-based care plan to study difference in health outcomes

Patients with diabetes who follow a self-care regimen generally have success in controlling their disease. But what about patients whose other health conditions, such as cognitive impairment and/or depression, create barriers to effective treatment?

17 Dec 2010

'Histone code' needs to be used with caution

The function of histones -- the proteins that enable yards of DNA to be crammed into a single cell -- depends on a number of chemical tags adorning their exterior. This sophisticated chemical syntax for packaging DNA into tight little coils or unraveling it again -- called the "histone code" -- is the latest frontier for researchers bent on understanding how genetics encodes life.

17 Dec 2010

Whitehead Institute Founding Member named recipient of 2011 Warren Triennial Prize of MGH

Whitehead Institute Founding Member Rudolf Jaenisch has been named a recipient of the 2011 Warren Triennial Prize of Massachusetts General Hospital.

17 Dec 2010

Catalyst receives $4.0M milestone payment from Pfizer under hemophilia Factor VIIa program

Catalyst Biosciences, Inc., the leading company in the discovery and development of engineered proteases, today announced the receipt of a $4.0 million milestone payment from Pfizer Inc. under the terms of the collaboration agreement for the development of improved recombinant human Factor VIIa variants for the treatment of hemophilia and other bleeding disorders.

17 Dec 2010

MDA awards Repligen $1.4M for research of new compound with therapeutic potential for SMA

The Muscular Dystrophy Association today announced it has awarded $1.4 million in new research funding to the biopharmaceutical firm Repligen of Waltham, Mass., to complete the preclinical work needed to begin human clinical trials of a promising therapeutic compound for spinal muscular atrophy (SMA).

17 Dec 2010

Merck, sanofi-aventis enter global cancer research and development agreement

Merck Serono, a division of Merck KGaA, Darmstadt, Germany, announced today that Merck, has signed a worldwide research and development agreement with sanofi-aventis U.S. Inc., under which Merck Serono and sanofi-aventis U.S. Inc. will collaboratively investigate novel experimental combinations of agents that could block specific pathways in cancer cells. This collaboration could deliver novel targeted oncology treatments with high therapeutic potential.

17 Dec 2010

Researchers discover new molecular mechanism of Alzheimer's disease through protein interaction

Through a complex analysis of protein interactions, researchers from IRB Barcelona and the Joint Programme IRB-BSC have discovered new molecular mechanisms that may be involved in the development of Alzheimer's disease.

17 Dec 2010

Pediatric cancer researchers study medulloblastoma for new treatment

Pediatric cancer researchers at The Children's Hospital of Philadelphia contributed important expertise to a new landmark study of medulloblastoma, a type of brain tumor typically found in children.

17 Dec 2010

Study: Natural high hemoglobin levels safe for kidney disease patients on dialysis

Naturally occurring high hemoglobin levels are safe for kidney disease patients on dialysis, according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology.

17 Dec 2010

Over quarter million women who gave birth in hospitals had pre-existing diabetes or developed gestational diabetes

More than a quarter million women who gave birth in U.S. hospitals in 2008 had pre-existing diabetes or developed it during their pregnancy - a condition called gestational diabetes, according to the latest News and Numbers from the Agency for Healthcare Research and Quality. This equals 6.4 percent of the 4.2 million women who gave birth in that year.

17 Dec 2010

Study reveals immune cell provides new therapeutic strategy for SLE

A new study provides fascinating insight into the underlying pathology associated with the autoimmune disease, systemic lupus erythematosus.

16 Dec 2010

Genetic breakthrough in lung cancer

For the study the team studied samples of lung tumors and nearby healthy lung tissue from 30 patients and examined the samples for the presence of messenger ribonucleic acid (mRNA) associated with 48 known genes for molecules called nuclear hormone receptors. Then they compared the active genes with patient outcomes and found that the expression of genes for certain nuclear hormone receptors helped predict patient survival.

16 Dec 2010

Gene variant linked to liver cirrhosis in Caucasians

A new study by German researchers found that a variation in the PNPLA3 (adiponutrin) gene was associated with cirrhosis of the liver and elevated transaminase (liver enzyme) levels in alcoholic Caucasians. The risk of cirrhosis in alcoholics in the genetic high risk group might be as high as 25 to 50%. Full findings are published in the January 2011 issue of Hepatology, a journal of the American Association for the Study of Liver Diseases.

16 Dec 2010

Liver cancer in cirrhotic patients effectively treated with radiofrequency ablation

Researchers from Italy determined that radiofrequency ablation (RFA) is a safe and effective therapy for managing hepatocellular carcinoma (HCC) in cirrhotic patients. The high repeatability of RFA is advantageous in controlling recurrences of cancerous tumors in the liver. Results of this 10-year retrospective study are available in the January 2011 issue of Hepatology, a journal published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases (AASLD).

16 Dec 2010

Some cancers more prevalent in the wealthy

A new report has shown that Australians living in wealthy areas are more likely to get breast, prostate and skin cancers than those living in poorer zones. The report from Australian Institute of Health and Welfare, released yesterday also shows that those living in disadvantaged parts of the country are more likely to have bowel, cervical and lung cancers. Not so much with bowel cancer, but lung cancer incidence varied to a large extent. Main results showed;

16 Dec 2010

Akonni receives $150,000 Phase I NSF grant to assess feasibility of developing lab-on-a-film microarray device

Akonni Biosystems, a molecular diagnostics company that develops, manufactures, and plans to market sophisticated molecular testing devices for diagnosing infectious diseases and human genetic disorders, announced today the receipt of a $150,000 Phase I Grant from the National Science Foundation (NSF). This initial round of funding from NSF will enable Akonni to assess the feasibility of developing a lab-on-a-film microarray device that can be manufactured in a reel-to-reel format.

16 Dec 2010

GSK to deploy BioClinica's Trident IWR system across Phase I-IV clinical trials

BioClinica®, Inc.,, a global provider of clinical trial management services, today announced that GlaxoSmithKline LLC ("GSK") has signed a multi-year enterprise technology agreement to deploy BioClinica's Trident IWR (Interactive Web Response) system across its Phase I-IV clinical trials.

From Clario 16 Dec 2010

Discovery Labs awarded NIH Fast Track SBIR grant for developing aerosolized KL4 surfactant for RDS

Discovery Laboratories, Inc. today announced that the Company has been awarded Phase I of a Fast Track Small Business Innovation Research Grant (SBIR) from the National Institutes of Health (NIH) to support the development of the Company's program for aerosolizing KL4 surfactant for neonatal respiratory distress syndrome (RDS).

16 Dec 2010

Medical Research News

Research project examines unfamiliar space to make it 'older person-friendly'

Gene variant affects brain function long before brain begins accumulating amyloid: Study

City Tech Nursing Professor provides community-based care plan to study difference in health outcomes

'Histone code' needs to be used with caution

Whitehead Institute Founding Member named recipient of 2011 Warren Triennial Prize of MGH

Catalyst receives $4.0M milestone payment from Pfizer under hemophilia Factor VIIa program

MDA awards Repligen $1.4M for research of new compound with therapeutic potential for SMA

Merck, sanofi-aventis enter global cancer research and development agreement

Researchers discover new molecular mechanism of Alzheimer's disease through protein interaction

Pediatric cancer researchers study medulloblastoma for new treatment

Study: Natural high hemoglobin levels safe for kidney disease patients on dialysis

Over quarter million women who gave birth in hospitals had pre-existing diabetes or developed gestational diabetes

Study reveals immune cell provides new therapeutic strategy for SLE

Genetic breakthrough in lung cancer

Gene variant linked to liver cirrhosis in Caucasians

Liver cancer in cirrhotic patients effectively treated with radiofrequency ablation

Some cancers more prevalent in the wealthy

Akonni receives $150,000 Phase I NSF grant to assess feasibility of developing lab-on-a-film microarray device

GSK to deploy BioClinica's Trident IWR system across Phase I-IV clinical trials

Discovery Labs awarded NIH Fast Track SBIR grant for developing aerosolized KL4 surfactant for RDS

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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