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Double binding sites on tumor target may provide future combination therapy

Researchers from the University of Pennsylvania School of Medicine and colleagues at Merck Serono Research in Germany have found that two drugs bind to receptor sites on some tumors in different places at the same time, suggesting the possibility of a new combination therapy for certain types of cancer.

9 Apr 2008

Discovery of a critical early player in the path that turns cells to fat

Given that obesity - defined as an excess amount of body fat relative to lean body mass - is a major health concern in the United States and an increasing problem in the developing world, such a fuller understanding of the molecular processes governing fat tissue formation could ultimately hold clinical importance, according to the researchers.

9 Apr 2008

Scientists block early step in metastasis of prostate cancer cells

Recent studies have suggested an association between chronic inflammation and cancers of the prostate, colon, stomach and liver.

9 Apr 2008

A diaphanous control during embryo formation

The research now published in the journal Development shows how Dia mutations in fruit flies embryos result in a serious of defects during morphogenesis (process by which cells differentiate into tissues and structures), including loss of adhesion, abnormal movements and even migration of cells from one tissue to another.

9 Apr 2008

Smoking bans and taxes, do they work?

British researchers say some of the recent strategies employed to reduce the dangers of smoking may not be as effective as imagined.

9 Apr 2008

Depressives at an increase risk for Alzheimer's

According to researchers in Holland people who are depressed are at an increased risk of developing Alzheimer's disease.

9 Apr 2008

Beetroot juice lowers blood pressure

Scientists in the UK claim that drinking a glass of beetroot juice each day can help reduce high blood pressure.

9 Apr 2008

Thin people may still have a high body fat ratio

Anyone concerned about gaining extra weight will be confused by the latest research as scientists in the U.S. say being thin is no guarantee a person has a low body fat ratio.

9 Apr 2008

Biological link between pain and fatigue discovered

A recent University of Iowa study reveals a biological link between pain and fatigue and may help explain why more women than men are diagnosed with chronic pain and fatigue conditions like fibromyalgia and chronic fatigue syndrome.

8 Apr 2008

Genetic factors associated with common fears

Genetic factors that are associated with fears appear to change as children and adolescents age, with some familial factors declining in importance over time while other genetic risk factors arise in adolescence and adulthood, according to a report in the April issue of Archives of General Psychiatry.

8 Apr 2008

Potential new therapy for myeloproliferative disorders

A unique partnership between industry and academia has led to human clinical trials of a new drug for a rare class of blood diseases called myeloproliferative disorders (MPD), which are all driven by the same genetic mutation and can evolve into leukemia.

8 Apr 2008

Irregular sleep patterns and shift work linked to organ disease

Disruption of an individual's natural sleep-wake cycle has been determined to be a contributing factor in the development of organ disease.

8 Apr 2008

New regulatory circuit identified for aggressive, malignant brain tumor

Research using a newly developed algorithm has significantly advanced understanding of the molecular events associated with the most common primary brain tumor in adults, human glioblastoma (GBM).

8 Apr 2008

Identification of dopamine 'mother cells' could lead to future Parkinson's treatments

'Mother cells' which produce the neurons affected by Parkinson's disease have been identified by scientists, according to new research published in the journal Glia.

8 Apr 2008

Genetic variants of USF1 are associated with the increased risk for cardiovascular disease

Cardiovascular diseases (CVD) are major contributors to morbidity and mortality worldwide.

8 Apr 2008

New decontamination agent

A new decontamination agent devised by US chemists can deactivate toxic chemicals such as nerve agents and pesticides - leaving only non-toxic, easily disposable by-products, according to research in the New Journal of Chemistry.

8 Apr 2008

Neglect or abuse in childhood linked to adult inflammation, depression

A history of neglect or abuse in childhood appears to be associated with depression and inflammation in adulthood, a combination that may increase cardiovascular risk, according to a report in the April issue of Archives of General Psychiatry , one of the JAMA/Archives journals.

8 Apr 2008

Caffeine prevents multiple sclerosis-like disease in mice

Mice given caffeine equivalent to a human drinking six to eight cups of coffee a day were protected from developing experimental autoimmune encephalomyelitis (EAE), the animal model for the human disease Multiple Sclerosis (MS), according to researchers at Cornell University.

8 Apr 2008

Blood pressure enzyme can have tumor-sensing role

By increasing production of a blood pressure-regulating enzyme in mice, researchers have found they can enhance the mouse immune system's ability to sense tumor growth.

8 Apr 2008

Asthma and smoker's lung: dry airways play a key role

Dry airways may not only play a central role in the development of the inherited lung disease cystic fibrosis, but also in much more common acquired chronic lung diseases such as asthma and smoker's lung, the cigarette smoke-induced chronic obstructive pulmonary disease (COPD).

8 Apr 2008