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Celebrex like gene suppresses the growth of colon cancer

Cancer researchers at the Case Western Reserve University (Case) School of Medicine, University Hospitals of Cleveland (UHC) and the Howard Hughes Medical Institute have found a "Celebrex-like" gene that suppresses the growth of colon cancer.

13 Dec 2004

Compounds in Christmas trees could help treat arthritis and pain

Researchers have identified a group of anti-inflammatory compounds in the bark of the Scotch pine - widely used for Christmas trees - that they say could be developed into food supplements or drugs for treating arthritis and pain.

13 Dec 2004

Association between gastrointestinal disorders and sleep disturbances

Mayo Clinic researchers report in the current issue of Mayo Clinic Proceedings an association between gastrointestinal disorders and sleep disturbances. The association is important because these problems cause significant health issues including greater need for general medical and mental health treatment.

13 Dec 2004

Findings could lead to new knowledge that could speed the development of drugs to block botulism or tetanus toxins more rapidly

The first detailed structure of a botulism toxin attached to its target protein reveals that the toxin snakes the protein around itself — a sort of “reverse anaconda” — to recognize the receptor.

13 Dec 2004

Computational model of addiction which can be used to make predictions about human behavior

A University of Minnesota researcher developed a computational model of addiction which can be used to make predictions about human behavior, animal behavior, and neurophysiology.

13 Dec 2004

Newly discovered genetic defect might represent an important risk factor for major depression

A newly discovered genetic defect might represent an important risk factor for major depression, a condition which effects 20 million people in the U.S., according to Duke University Medical Center researchers.

13 Dec 2004

Injectable gel that could speed repair of torn cartilage

In a project that will likely be watched by football players, runners and other athletes, researchers at MIT and Harvard Medical School say they are developing an injectable gel that could speed repair of torn cartilage, a common sports injury, and may help injured athletes return to competition sooner.

13 Dec 2004

First gene therapy for skin cancer

Researchers at UT Southwestern Medical Center at Dallas have successfully tested the first gene therapy for skin cancer, using a mouse model for the disease xeroderma pigmentosum, or XP.

13 Dec 2004

Using precise, radioactively labeled genetic probes, researchers study cancer gene activity from outside the body

Using precise, radioactively labeled genetic probes, researchers at Jefferson Medical College have seen cancer gene activity from outside the body in laboratory mice. The probes, which work by attaching to genetic codes copied from an active cancer gene, may someday aid physicians and scientists in cancer detection and in determining the appropriate treatment for a cancer.

13 Dec 2004

Celecoxib may regulate a cell's use of estrogen - might help explain the drug's anticancer properties

Six months of treatment with celecoxib (Celebrex) in women at risk of developing breast cancer results in the reduction of estrogen receptor expression in breast cells, a research team at The University of Texas M. D. Anderson Cancer Center has found.

13 Dec 2004

Novel anti-rejection protocol should allow major improvement efficacy and quality of life after intestinal and multivisceral transplants

Transplant researchers at the University of Pittsburgh's Thomas E. Starzl Transplantation Institute have dramatically improved intestinal transplant graft survival, and reduced rejection and infection rates by successfully using a novel immunosuppression minimization protocol, thus improving patients' overall quality of life and avoiding the use of several anti-rejection drugs, which can cause serious infections and major complications.

13 Dec 2004

Importance of the phosphatidylinositol 3 kinase (PI3K) pathway to breast cancer development

Because up to 75 percent of breast cancer patients have an abnormality in a specific cell signaling pathway, drugs that target different molecules along that pathway may be especially effective for treating the disease, says a researcher from The University of Texas M. D. Anderson Cancer Center.

13 Dec 2004

Key molecular signal allows malarial parasites to target human red blood cells

Northwestern University researchers have identified a key molecular "signal" that allows malarial parasites to release virulence proteins inside human red blood cells.

13 Dec 2004

Cell replacement therapy offers a novel and powerful medical technology

Cell replacement therapy offers a novel and powerful medical technology. A type of embryonic stem cell, called a neural crest stem cell, that persists into adulthood in hair follicles was recently discovered by Maya Sieber-Blum, Ph.D., of the Medical College of Wisconsin, Milos Grim, MD Ph.D., of Charles University Prague, and their collaborators.

13 Dec 2004

Helping to heal complications from spinal cord injury

A London scientist has received a major grant to help improve the quality of life for individuals with spinal cord injuries.

8 Dec 2004

New malaria enzyme laid bare with help of computer calculations

Using only computers, a research team at Uppsala University in Sweden has managed to reveal both the structure and the function of a newly discovered enzyme from the most dangerous malaria parasite, Plasmodium falciparum.

8 Dec 2004

Trimming fat overcomes one of the major obstacles to drug design

Biochemists at Ohio State University and their colleagues have overcome one of the major obstacles to drug design, by trimming some of the fat from a molecular sponge that scientists use to study proteins.

8 Dec 2004

Teen-agers suffering from bulimia may also be struggling with a chronic form of depression

Teen-agers suffering from bulimia may in fact be fighting a two-front war, coping with the effects of a devastating eating disorder while struggling with a chronic form of depression, reveals research by Texas A&M University psychologist Marisol Perez

8 Dec 2004

New research is allowing biochemists to understand a key hierarchy of protein interactions that occurs in DNA

"All cancers are marked by some form of DNA replication gone awry, so a basic understanding of DNA replication is of paramount importance to those designing cancer-fighting drugs,"

8 Dec 2004

Resveratrol antioxidant found in red wine may benefit heart tissue

New research on rat heart cells suggests that a well-known antioxidant found in red wine, called resveratrol, may benefit heart tissue by limiting the effects of a condition called cardiac fibrosis.

8 Dec 2004

Medical Research News

Celebrex like gene suppresses the growth of colon cancer

Compounds in Christmas trees could help treat arthritis and pain

Association between gastrointestinal disorders and sleep disturbances

Findings could lead to new knowledge that could speed the development of drugs to block botulism or tetanus toxins more rapidly

Computational model of addiction which can be used to make predictions about human behavior

Newly discovered genetic defect might represent an important risk factor for major depression

Injectable gel that could speed repair of torn cartilage

First gene therapy for skin cancer

Using precise, radioactively labeled genetic probes, researchers study cancer gene activity from outside the body

Celecoxib may regulate a cell's use of estrogen - might help explain the drug's anticancer properties

Novel anti-rejection protocol should allow major improvement efficacy and quality of life after intestinal and multivisceral transplants

Importance of the phosphatidylinositol 3 kinase (PI3K) pathway to breast cancer development

Key molecular signal allows malarial parasites to target human red blood cells

Cell replacement therapy offers a novel and powerful medical technology

Helping to heal complications from spinal cord injury

New malaria enzyme laid bare with help of computer calculations

Trimming fat overcomes one of the major obstacles to drug design

Teen-agers suffering from bulimia may also be struggling with a chronic form of depression

New research is allowing biochemists to understand a key hierarchy of protein interactions that occurs in DNA

Resveratrol antioxidant found in red wine may benefit heart tissue

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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