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Neurons protect intestinal tissue from over-inflammation

The immune system exercises constant vigilance to protect the body from external threats--including what we eat and drink. A careful balancing act plays out as digested food travels through the intestine. Immune cells must remain alert to protect against harmful pathogens like Salmonella, but their activity also needs to be tempered since an overreaction can lead to too much inflammation and permanent tissue damage.

25 Jan 2016

Orthocell to present positive data from pilot study of tendon cell treatment at international hip meeting

Regenerative medicine company Orthocell Limited is pleased to announce it will present new positive two year data from a study of its tendon cell treatment for degenerate hip (gluteal) tendons at the 3rd Melbourne International Hip Arthroscopy meeting.

25 Jan 2016

Ageing 2016 summit to explore various aspects of processes, research on ageing and senescence

Ageing 2016 will be held from February 9 to 11, 2016 at Cineworld: The O2 Peninsula Square London SE10 0DX United Kingdom. The annual international summit will look at the various aspects of processes and research involved in ageing and senescence.

25 Jan 2016

New €5.6 million project aims to develop cell-based haemophilia A therapy

Loughborough University is working with a team of international partners on a new €5.6 million project to develop a cell based haemophilia A therapy.

25 Jan 2016

Scientists find how APOBEC protein becomes dangerous when DNA replication process goes wrong

Cancer is caused by the growth of an abnormal cell which harbours DNA mutations, "copy errors" occurring during the DNA replication process. If these errors do take place quite regularly without having any damaging effect on the organism, some of them affect a specific part of the genome and cause the proliferation of the mutant cell, which then invades the organism.

25 Jan 2016

Neurocutaneous disorders affect skin, nervous system

One of the most common genetic disorders is a condition called neurofibromatosis, which causes brown spots on the skin and benign tumors on the brain, spinal cord and other parts of the nervous system.

25 Jan 2016

CNIC researchers identify how two proteins control heart growth and adaptation to hypertension

Researchers at the Centro Nacional de Investigaciones Cardiovasculares Carlos III have identified how two proteins control the growth of the heart and its adaptation to high blood pressure (hypertension).

25 Jan 2016

UAB study shows IL-37 protein suppresses inflammatory response after spinal cord injury

Spinal cord injuries cause severe functional disabilities in those who sustain them, including paraplegia or tetraplegia, depending on the scale of the injury. This is due to the degeneration of the spinal pathways that carry nerve signals from the brain to the different parts of the body and vice versa, resulting in loss of mobility and sensitivity underneath the injured area.

22 Jan 2016

Levels of mitochondrial DNA in the blood may predict chronic kidney disease risk

The health of blood cells' energy-producing mitochondria may predict a person's risk of developing chronic kidney disease (CKD), according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology.

22 Jan 2016

PGD model could provide policy guideposts for human genome editing

Human genome editing for both research and therapy is progressing, raising ethical questions among scientists around the world.

22 Jan 2016

Sensitive computational method could help reveal effect of the immune system on cancer

A study by researchers at Norris Cotton Cancer Center has shown that a very sensitive computational method can be used to reveal the human immune system's effect on cancer. The Dartmouth study was the first to perform an in-depth computational examination of how immune activity translates to prognosis in breast cancer.

22 Jan 2016

Researchers explore ways to use light to combat cancer

Immunotherapy is one of the hottest emerging areas of cancer research. After all, using the body's own cells to fight cancer can be more effective and less invasive than flooding the entire system with toxic chemicals.

22 Jan 2016

Colon cancer patients lacking CDX2 protein more likely to benefit from chemotherapy

Using a new computer science approach, researchers at University of California, San Diego School of Medicine, Columbia University and Stanford University discovered a distinctive molecular feature — a biomarker — that identified colon cancer patients who were most likely to remain disease-free up to five years after surgery.

22 Jan 2016

Higher-order thalamus enhances and temporarily stores sensory signals

Every day, we constantly absorb information through our sensory organs, which the brain then needs to process correctly. The information initially reaches the main relay center, the thalamus, and then travels to the cerebral cortex.

22 Jan 2016

CU Cancer Center study finds distinct genetic drivers of colorectal cancer in younger and older patients

A University of Colorado Cancer Center study being presented Saturday at the 2016 Genitourinary Cancers Symposium shows genetic differences between colorectal cancer (CRC) in young and old patients, possibly pointing toward different treatments and strategies in combating the young form of the disease.

22 Jan 2016

Study finds possibility of targeting Orai3 as novel treatment for obesity-related inflammation

A new study by a team of Rosalind Franklin University researchers headed by Carl White, PhD, assistant professor of physiology and biophysics, has discovered that the degree of chronic inflammation caused by obesity is highly dependent on levels of the signaling molecule, hydrogen sulfide, which alters the activity of a calcium channel, Orai3.

22 Jan 2016

Researchers use ASC secreted factors to create therapeutic factor concentrate for critical limb ischemia

"Critical limb ischemia" (CLI) describes an advanced stage of peripheral artery disease characterized by obstruction of the arteries and a markedly reduced blood flow to the extremities. CLI identifies patients at high-risk for major amputation. The estimated annual incidence of CLI ranges between 500 and 1000 new cases out of one million people per year, with the highest rates among the elderly, smokers, and those with diabetes. CLI is considered to be a critical public health issue. Attempts at revascularization are often unsuccessful.

22 Jan 2016

UT Southwestern researchers reveal how CDK4/6-inhibitors alter pancreatic cancer cell metabolism

UT Southwestern Medical Center researchers have found that cancer drugs known as CDK4/6-inhibitors alter the metabolism of pancreatic cancer cells, revealing a biologic vulnerability that could be exploited for therapeutic gain.

22 Jan 2016

Dartmouth researchers discover rare natural products that promote regeneration of injured nerve cells

Nerve damage from neurodegenerative disease and spinal cord injury has largely been considered irreversible, but Dartmouth researchers report progress in the effort to synthesize rare natural products that promote regeneration and growth of injured nerve cells.

22 Jan 2016

Cells communicate to their neighbors and compare notes before making a move

To decide whether and where to move in the body, cells must read chemical signals in their environment. Individual cells do not act alone during this process, two new studies on mouse mammary tissue show. Instead, the cells make decisions collectively after exchanging information about the chemical messages they are receiving.

22 Jan 2016

Medical Science News

Neurons protect intestinal tissue from over-inflammation

Orthocell to present positive data from pilot study of tendon cell treatment at international hip meeting

Ageing 2016 summit to explore various aspects of processes, research on ageing and senescence

New €5.6 million project aims to develop cell-based haemophilia A therapy

Scientists find how APOBEC protein becomes dangerous when DNA replication process goes wrong

Neurocutaneous disorders affect skin, nervous system

CNIC researchers identify how two proteins control heart growth and adaptation to hypertension

UAB study shows IL-37 protein suppresses inflammatory response after spinal cord injury

Levels of mitochondrial DNA in the blood may predict chronic kidney disease risk

PGD model could provide policy guideposts for human genome editing

Sensitive computational method could help reveal effect of the immune system on cancer

Researchers explore ways to use light to combat cancer

Colon cancer patients lacking CDX2 protein more likely to benefit from chemotherapy

Higher-order thalamus enhances and temporarily stores sensory signals

CU Cancer Center study finds distinct genetic drivers of colorectal cancer in younger and older patients

Study finds possibility of targeting Orai3 as novel treatment for obesity-related inflammation

Researchers use ASC secreted factors to create therapeutic factor concentrate for critical limb ischemia

UT Southwestern researchers reveal how CDK4/6-inhibitors alter pancreatic cancer cell metabolism

Dartmouth researchers discover rare natural products that promote regeneration of injured nerve cells

Cells communicate to their neighbors and compare notes before making a move

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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