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Researchers find correlation between biomarker and patient’s ability to respond to Imprime PGG

Biothera researchers have broadened their understanding of a biomarker that may enable doctors to predict which cancer patients will best respond to Imprime PGG®, the company's immunotherapy in Phase 3 drug development for colorectal cancer.

5 Dec 2013

Alvotech to invests $250M in the development of biosimilar monoclonal antibodies

Alvotech, a powerful new player in the field of biopharmaceuticals, today announced plans to invest $250 million in the development and manufacturing of a portfolio of biosimilar monoclonal antibodies.

5 Dec 2013

Brain anatomy affects cognitive control in children

The anatomy of the brain affects cognitive control, an essential skill for learning and academic success. This is the result of studies performed by the Laboratoire de Psychologie du Développement et de l'Education de l'Enfant (CNRS/Université Paris Descartes/Université de Caen Basse-Normandie), in collaboration with the NeuroSpin Center (CEA).

5 Dec 2013

New research shows that the brain can produce and release estrogen

A University of Wisconsin-Madison research team reports today that the brain can produce and release estrogen - a discovery that may lead to a better understanding of hormonal changes observed from before birth throughout the entire aging process.

5 Dec 2013

Findings suggest new approach for treating inflammatory bone diseases and skeletal metastases

The skeleton is constantly being remodelled by the breakdown of old bone by cells called osteoclasts and the formation of new bone by cells called osteoblasts. This coordinated activity is essential for maintaining healthy bone. However, excessive osteoclast activity leads to bone destruction in skeletal diseases such as osteoporosis, rheumatoid arthritis and cancer metastases in bone. A family of signaling enzymes known as phosphatidylinositol 3-kinases control diverse cell functions but, up until now, little was known about the function of specific PI3K isoforms in osteoclasts.

5 Dec 2013

Biologists discover how nerve cells recycle tiny vesicles

University of Utah and German biologists discovered how nerve cells recycle tiny bubbles or "vesicles" that send chemical nerve signals from one cell to the next. The process is much faster and different than two previously proposed mechanisms for recycling the bubbles.

5 Dec 2013

New report analyzes growth and development of stem cell field

Elsevier, EuroStemCell, and Kyoto University's Institute for Integrated Cell-Material Sciences, today released "Stem Cell Research report: Trends and Perspectives on the Evolving International Landscape" at the World Stem Cell Summit. This new, comprehensive analysis of the growth and development of the stem cell field as a whole, closely examines the research landscape for embryonic stem cell, human embryonic stem cell and induced pluripotent stem cell.

5 Dec 2013

Research: Low level of daily exposure to sunlight can cause skin damage

A low level of daily exposure to a common component of sunlight can cause skin damage at the molecular level after just a few days, new University of Michigan Medical School research shows.

5 Dec 2013

B2G2 component of grape seed extract induces apoptosis in prostate cancer cells

A University of Colorado Cancer Center study published online ahead of print in the journal Nutrition and Cancer describes the laboratory synthesis of the most active component of grape seed extract, B2G2, and shows this synthesized compound induces the cell death known as apoptosis in prostate cancer cells while leaving healthy cells unharmed.

5 Dec 2013

TLR4 antibody-mediated signaling system in apoptosis of hippocampal neurons

Toll-like receptor 4 (TLR4) antibody, protein kinase B (AKT) inhibitor, LY 294002, and glycogen synthase kinase 3β (GSK-3β) inhibitor, LiCl, were used by Yu He and colleagues from Nantong University, China to attenuate or augment the effects of the TLR4-phosphatidylinositol 3 kinase (PI3K)/AKT-GSK-3β signaling pathway so as to identify the participation of this signaling system in the apoptosis of hippocampal neurons.

5 Dec 2013

UCSB researcher tracks source of E280A gene mutation responsible for early-onset Alzheimer's

The age and origin of the E280A gene mutation responsible for early-onset Alzheimer's in a Colombian family with an unusually high incidence of the disease has been traced to a single founder dating from the 16th century.

5 Dec 2013

New method for counting tumor-fighting cells to predict ovarian cancer

One way to predict survival of many types of cancer is by counting the number of tumor-attacking immune cells that have migrated into the tumor in an effort to eradicate it - a sign of the body's immune response to the cancer. However, quantifying these armies of immune cells has been difficult - until now.

5 Dec 2013

Tongue twisters can open windows into the brain's speech-planning processes

Tongue twisters are not just fun to say; it turns out that these sound-related slip-ups can also open windows into the brain's speech-planning processes. A team from the Massachusetts Institute of Technology (MIT) will report new insights gleaned from a comparison of two types of tongue twisters at the 166th meeting of the Acoustical Society of America (ASA), held Dec. 2-6, 2013, in San Francisco, Calif

5 Dec 2013

Stomach circadian clock limits food intake to specific times of day

University of Adelaide researchers have discovered the first evidence that the nerves in the stomach act as a circadian clock, limiting food intake to specific times of the day.

5 Dec 2013

Scientists receive $4M grant to identify biomarker for secondary injuries associated with brain

In an effort to lower medical costs, identify patients at risk for injury, and speed patient recovery, scientists will attempt to identify a molecular signal that indicates severity of brain-injury during a $4 million, five-year federal grant to Barrow Neurological Institute at St. Joseph's Hospital and Medical Center, Phoenix Children's Hospital and the Translational Genomics Research Institute (TGen).

5 Dec 2013

Study: Track-side noise may exceed 8,500% of person's daily recommended noise exposure

As an acoustical engineer, Craig Dolder - currently a graduate student at the University of Texas, Austin - knew that loud noises can damage hearing. Even so, when Canada's Formula 1 Grand Prix coincided with an Acoustical Society of America (ASA) meeting that he was attending in Montreal, Quebec, earlier this year, Dolder was drawn to the racetrack and the deafening roar of the Formula 1 engines.

5 Dec 2013

New research offers fresh insights to drug designers searching for better pain treatments

In a technical tour de force, UC San Francisco scientists have determined, at near-atomic resolution, the structure of a protein that plays a central role in the perception of pain and heat.

5 Dec 2013

Blocking Cdh1 protein could accelerate development of new therapies targeting cancer

The laboratory of Marcos Malumbres, who is head of the Spanish National Cancer Research Centre's (CNIO) Cell Division & Cancer Group, working alongside Isabel Fari-as' team from the University of Valencia, shows, in a study published today in the journal Nature Communications, how in mice the elimination of the Cdh1 protein -a sub-unit of the APC/C complex, involved in the control of cell division-prevents cellular proliferation of rapidly dividing cells.

5 Dec 2013

Baicalin inhibits colistin sulfate-induced apoptosis of PC12 cells

Baicalin, a type of flavonoid extracted from the dried root of Scutellaria baicalensis georgi, has been shown to effectively inhibit cell apoptosis. Colistin sulfate, a cyclic cationic polypeptide antibiotic, has been shown to have renal and neurological side effects.

4 Dec 2013

UCLA researchers discover how prostate cancer stem cells evolve as the disease grows

UCLA researchers have discovered how prostate cancer stem cells evolve as the disease progresses, a finding that could help point the way to more highly targeted therapies.

4 Dec 2013

Medical Science News

Researchers find correlation between biomarker and patient’s ability to respond to Imprime PGG

Alvotech to invests $250M in the development of biosimilar monoclonal antibodies

Brain anatomy affects cognitive control in children

New research shows that the brain can produce and release estrogen

Findings suggest new approach for treating inflammatory bone diseases and skeletal metastases

Biologists discover how nerve cells recycle tiny vesicles

New report analyzes growth and development of stem cell field

Research: Low level of daily exposure to sunlight can cause skin damage

B2G2 component of grape seed extract induces apoptosis in prostate cancer cells

TLR4 antibody-mediated signaling system in apoptosis of hippocampal neurons

UCSB researcher tracks source of E280A gene mutation responsible for early-onset Alzheimer's

New method for counting tumor-fighting cells to predict ovarian cancer

Tongue twisters can open windows into the brain's speech-planning processes

Stomach circadian clock limits food intake to specific times of day

Scientists receive $4M grant to identify biomarker for secondary injuries associated with brain

Study: Track-side noise may exceed 8,500% of person's daily recommended noise exposure

New research offers fresh insights to drug designers searching for better pain treatments

Blocking Cdh1 protein could accelerate development of new therapies targeting cancer

Baicalin inhibits colistin sulfate-induced apoptosis of PC12 cells

UCLA researchers discover how prostate cancer stem cells evolve as the disease grows

Microphysiological systems in drug discovery

Considerations for taking ASO discovery programs into animal models

Neurofilament light as a translational biomarker

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