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IRCM researcher sheds light on inconsistencies between pharmacogenomic studies

A bioinformatics expert at the IRCM, Benjamin Haibe-Kains, recently published an article stressing the importance of standardizing drug screening studies in the prestigious scientific journal Nature. The study supports the need for further development and standardization to improve the reproducibility of drug screening studies, as they are important in identifying new therapeutic agents and their potential combinations with existing drugs.

3 Dec 2013

Study: Unfolded protein response can increase risk of sudden cardiac death

A researcher at the Cardiovascular Institute (CVI) at Rhode Island, The Miriam and Newport hospitals has found a link to human heart failure that if blocked, may reduce the risk of sudden cardiac death.

3 Dec 2013

Synaptic health in the brain closely linked to cognitive decline

Age-related cognitive decline and changes in the nervous system are closely linked, but up until recently, they were thought to result from the loss of neurons in areas such as the prefrontal cortex, the part of the brain important in working memory.

3 Dec 2013

New genetics promises to change faulty genes of future generations by using "designer sperm”

Bethesda, MD-Get ready: The "new genetics" promises to change faulty genes of future generations by introducing new, functioning genes using "designer sperm." A new research report appearing online in The FASEB Journal, shows that introducing new genetic material via a viral vector into the sperm of mice leads to the presence and activity of those genes in the resulting embryos.

3 Dec 2013

ATN-224 inhibitor reduces tumor sizes in mouse model of lung adenocarcinoma

Many cancers have adapted to cope with high levels of immune system-produced free radicals, also referred to as reactive oxygen species, by overproducing antioxidant proteins. One of these proteins, superoxide dismutase 1, is overproduced in lung adenocarcinomas and has been implicated as a target for chemotherapy.

3 Dec 2013

New finding links obesity and high-fat, high-sugar diets with changes in inflammatory status

Scientists have moved a step closer to an "obesity drug" that may block the effects of diets high in sugar and fats. In a new research report published in the December 2013 issue of The FASEB Journal, scientists show that there is an abnormal amount of an inflammatory protein called PAR2 in the abdominal fat tissue of overweight and obese humans and rats.

3 Dec 2013

Certain hormones which are increased during exercise may help improve memory

Researchers at Boston University School of Medicine (BUSM) have found further evidence that exercise may be beneficial for brain health and cognition. The findings, which are currently available online in Behavioural Brain Research, suggest that certain hormones, which are increased during exercise, may help improve memory.

3 Dec 2013

Oxygen levels play critical role in determining effectiveness of anti-inflammatory drugs

A new research discovery published in the December 2013 issue of the Journal of Leukocyte Biology yields an important clue toward helping curb runaway inflammation. Oxygen levels play a critical role in determining the severity of the inflammatory response and ultimately the effectiveness of anti-inflammatory drugs.

3 Dec 2013

VRC scientists receive $2.2M grant to develop new resin composite dental fillings

The American Dental Association and the ADA Foundation today announced that the foundation's Anthony Volpe Research Center (VRC) received a five-year, $2.2 million grant from the National Institute of Dental and Craniofacial Research (NIDCR) to develop new resin composite dental fillings.

3 Dec 2013

Researchers create computer algorithm to identify specific genes involved in breast cancer growth

Researchers from the University of Alberta and Alberta Health Services have created a computer algorithm that successfully predicts whether estrogen is sending signals to cancer cells to grow into tumours in the breast. By finding this hormone receptor, known as estrogen receptor positive, physicians can prescribe anti-estrogen drug therapies, improving patient outcomes.

3 Dec 2013

Valproic acid can enhance neuronal regeneration following brachial plexus root avulsion

Brachial plexus root avulsion is the most serious type of peripheral nerve injury. Valproic acid has been shown to exert neuroprotective effects and promote neurite outgrowth in several peripheral nerve injury models. However, whether valproic acid can exert its beneficial effect on neurons after brachial plexus avulsion injury is currently unknown.

3 Dec 2013

Scientists explain new family of proteins that appear to play key role in cancer

Scientists have described a new family of proteins that appear to play a key role in cancer and might be targets for future cancer drugs.

3 Dec 2013

Vitamin D2 supplementation is promising treatment for pain, depression in type 2 diabetes

Vitamin D decreases pain in women with type 2 diabetes and depression, according to a study conducted at Loyola University Chicago. These findings were presented at an Oct. 24, 2013 research conference at Loyola's Health Sciences Campus.

2 Dec 2013

Newly identified protein could prove promising new drug target for AIDS

Researchers have identified a protein that causes loss of function in immune cells combatting HIV. The scientists report in a paper appearing online Dec. 2 in the Journal of Clinical Investigation that the protein, Sprouty-2, is a promising target for future HIV drug development, since disabling it could help restore the cells' ability to combat the virus that causes AIDS.

2 Dec 2013

Recently discovered humanin peptide could lead to powerful new treatments for diabetes

Even if the obesity trend cannot be reversed, here's hope that it's partner in crime-diabetes-might be thwarted. New research published in the December 2013 issue of The FASEB Journal shows how a recently discovered human peptide, called humanin, could lead to powerful new treatments for some people living with diabetes.

2 Dec 2013

Study: Diet low in vitamin D can cause free radical damage in brain

A new study led by University of Kentucky researchers suggests that a diet low in vitamin D causes damage to the brain.

2 Dec 2013

Investigators use new technique to identify pathogens faster, directly from clinical samples

A team of Danish investigators has shown how to identify pathogens faster, directly from clinical samples. The research, published online ahead of print in the Journal of Clinical Microbiology appears in the journal's January 2014 issue.

2 Dec 2013

New biomarkers to improve diagnostics of prostate cancer

New biomarkers will improve diagnostics of endemic diseases in future, such as prostate cancer. Their mission: to recognize the tumor earlier and classify it more precisely - thereby helping avoid unnecessary operations.

2 Dec 2013

USC scientists show gene-environment interaction augments risk for developing autism

Exposure to air pollution appears to increase the risk for autism among people who carry a genetic disposition for the neurodevelopmental disorder, according to newly published research led by scientists at the Keck School of Medicine of the University of Southern California.

2 Dec 2013

Scientists transform human stem cells into functional lung and airway cells

For the first time, scientists have succeeded in transforming human stem cells into functional lung and airway cells. The advance, reported by Columbia University Medical Center researchers, has significant potential for modeling lung disease, screening drugs, studying human lung development, and, ultimately, generating lung tissue for transplantation.

2 Dec 2013

Medical Science News

IRCM researcher sheds light on inconsistencies between pharmacogenomic studies

Study: Unfolded protein response can increase risk of sudden cardiac death

Synaptic health in the brain closely linked to cognitive decline

New genetics promises to change faulty genes of future generations by using "designer sperm”

ATN-224 inhibitor reduces tumor sizes in mouse model of lung adenocarcinoma

New finding links obesity and high-fat, high-sugar diets with changes in inflammatory status

Certain hormones which are increased during exercise may help improve memory

Oxygen levels play critical role in determining effectiveness of anti-inflammatory drugs

VRC scientists receive $2.2M grant to develop new resin composite dental fillings

Researchers create computer algorithm to identify specific genes involved in breast cancer growth

Valproic acid can enhance neuronal regeneration following brachial plexus root avulsion

Scientists explain new family of proteins that appear to play key role in cancer

Vitamin D2 supplementation is promising treatment for pain, depression in type 2 diabetes

Newly identified protein could prove promising new drug target for AIDS

Recently discovered humanin peptide could lead to powerful new treatments for diabetes

Study: Diet low in vitamin D can cause free radical damage in brain

Investigators use new technique to identify pathogens faster, directly from clinical samples

New biomarkers to improve diagnostics of prostate cancer

USC scientists show gene-environment interaction augments risk for developing autism

Scientists transform human stem cells into functional lung and airway cells

Microphysiological systems in drug discovery

Considerations for taking ASO discovery programs into animal models

Neurofilament light as a translational biomarker

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