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LifeSensors receives U.S. patent for development of novel DUB substrates

LifeSensors, Inc., a biotech company developing cutting-edge technologies for studying the ubiquitin pathway, has been awarded a U.S. patent for the development of novel, fluorescent di- and poly-ubiquitin deubiquitinase substrates (US 8,518,660).

16 Sep 2013

New approach subtypes cancers by shared genetic effects; a step toward personalized medicine

Cancer tumors almost never share the exact same genetic mutations, a fact that has confounded scientific efforts to better categorize cancer types and develop more targeted, effective treatments.

16 Sep 2013

Research findings bring scientists one step closer to preventing HIV infections

In a long-awaited finding, a team of Chinese and US scientists has determined the high-resolution atomic structure of a cell-surface receptor that most strains of HIV use to get into human immune cells. The researchers also showed where maraviroc, an HIV drug, attaches to cells and blocks HIV’s entry.

13 Sep 2013

Pew honors creative work on coronaviruses with biomedical researcher award

Cell biologist Carolyn Machamer, Ph.D is The Pew Charitable Trusts' biomedical researcher of the month for her creative work on coronaviruses. Specifically, Machamer studies how the family of viruses uses a host cell's machinery against it.

13 Sep 2013

Genetic deficiency in autism linked to specific molecular and cellular consequences

Brown University researchers have traced a genetic deficiency implicated in autism in humans to specific molecular and cellular consequences that cause clear deficits in mice in how well neurons can grow the intricate branches that allow them to connect to brain circuits. The researchers also show in their study (online Sep. 12, 2013, in Neuron) that they could restore proper neuronal growth by compensating for the errant molecular mechanisms they identified.

13 Sep 2013

Researchers develop new ways of preventing septic shock

The body's immune system is set up much like a home security system; it has sensors on the outside of cells that act like motion detectors — floodlights — that click on when there's an intruder rustling in the bushes, bacteria that seem suspect.

13 Sep 2013

Researchers show network of genes which enforce cooperative state within cells

We often think of human cells as tiny computers that perform assigned tasks, where disease is a result of a malfunction. But in the current issue of Science, researchers at The Mount Sinai Medical Center offer a radical view of health — seeing it more as a cooperative state among cells, while they see disease as result of cells at war that fight with each other for domination.

13 Sep 2013

Microbes living in unexpected environments can generate highly toxic methylmercury

Microbes that live in rice paddies, northern peat bogs and other previously unexpected environments are among the bacteria that can generate highly toxic methylmercury, researchers at Oak Ridge National Laboratory and the Smithsonian Environmental Research Center have learned.

13 Sep 2013

New Springer title explores history, social implications of the machines of sex research

Showtime viewers are looking forward to the widely anticipated new series, Masters of Sex, which tells the story of sex researchers William Masters and Virginia Johnson. And while Masters and Johnson may have been responsible for a part of the sexual revolution in America, what audiences may not know is how the tools used by these and other sex researchers have helped fuel both progress and oppression.

13 Sep 2013

Data can help scientists, physicians match precision drugs to cancer's genetic traits

More than 5,000 genetic profiles of tumor DNA have been completed in a large research study by scientists at Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Boston Children's Hospital designed to speed the development of personalized cancer care with precision treatments.

13 Sep 2013

Stem cells and gene therapy play important role in regeneration of inner ear hair cells

Since Moffat and Ramsden for the first time discovered the possibility of the auditory system in humans in 1977, over the last two decades, great progress has been made in physiopathological research on neurosensory hearing loss. J-rgensen and Mathiesen were the first authors to note the capacity for regeneration of the normal vestibular epithelium in adult Australian parrots.

13 Sep 2013

Pancreatic protein essential for maintaining functional state of beta cells

Researchers at the Pediatric Diabetes Research Center (PDRC) at the University of California, San Diego School of Medicine have shown that the pancreatic protein Nkx6.1 - a beta-cell enriched transcription factor - is essential to maintaining the functional state of beta cells.

13 Sep 2013

New behavioral therapy improves antidepressant treatment of OCD

NIMH grantees have demonstrated that a form of behavioral therapy can augment antidepressant treatment of obsessive compulsive disorder (OCD) better than an antipsychotic.

13 Sep 2013

Simple method helps identify individuals who retain too much sodium

Getting a second urine sample and blood pressure measure as patients head out of the doctor's office appears an efficient way to identify those whose health may be in jeopardy because their bodies hold onto too much sodium, researchers report.

13 Sep 2013

Study shows distinct molecular structures may predominate in brains of Alzheimer's patients

Alzheimer's disease is thought to be caused by the buildup of abnormal, thread-like protein deposits in the brain, but little is known about the molecular structures of these so-called beta-amyloid fibrils.

13 Sep 2013

Three-gene biomarker can help determine treatment option for early prostate cancer

The level of expression of three genes associated with aging can be used to predict whether seemingly low-risk prostate cancer will remain slow-growing, according to researchers at the Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center.

13 Sep 2013

Helper T cells important for AIDS vaccine development

A major new finding that will significantly advance efforts to create the world's first antibody-based AIDS vaccine was published today by researchers from the La Jolla Institute for Allergy and Immunology.

13 Sep 2013

Longer time sevoflurane preconditioning does not grant better neuroprotective effects, says study

Sevoflurane belongs to volatile anesthetics, and preconditioning with sevoflurane has been shown to exert protective effects against ischemic injury in the brain. But the mechanism is unclear.

13 Sep 2013

Discovery sheds light on boundaries between brain regions

If the violins were taken away from the musicians performing Beethoven's 9th symphony, the resulting composition would sound very different. If the violins were left on stage but the violinists were removed, the same mutant version of the symphony would be heard.

13 Sep 2013

Wnt proteins essential to formation of long-term memories

Scientists from the Florida campus of The Scripps Research Institute have found a group of proteins essential to the formation of long-term memories.

13 Sep 2013

Medical Science News

LifeSensors receives U.S. patent for development of novel DUB substrates

New approach subtypes cancers by shared genetic effects; a step toward personalized medicine

Research findings bring scientists one step closer to preventing HIV infections

Pew honors creative work on coronaviruses with biomedical researcher award

Genetic deficiency in autism linked to specific molecular and cellular consequences

Researchers develop new ways of preventing septic shock

Researchers show network of genes which enforce cooperative state within cells

Microbes living in unexpected environments can generate highly toxic methylmercury

New Springer title explores history, social implications of the machines of sex research

Data can help scientists, physicians match precision drugs to cancer's genetic traits

Stem cells and gene therapy play important role in regeneration of inner ear hair cells

Pancreatic protein essential for maintaining functional state of beta cells

New behavioral therapy improves antidepressant treatment of OCD

Simple method helps identify individuals who retain too much sodium

Study shows distinct molecular structures may predominate in brains of Alzheimer's patients

Three-gene biomarker can help determine treatment option for early prostate cancer

Helper T cells important for AIDS vaccine development

Longer time sevoflurane preconditioning does not grant better neuroprotective effects, says study

Discovery sheds light on boundaries between brain regions

Wnt proteins essential to formation of long-term memories

Considerations for taking ASO discovery programs into animal models

Neurofilament light as a translational biomarker

How can machine learning accelerate neuroscience behavior studies?

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