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Study on genetic capacity of diverse populations to make critical PUFAs

World-renowned scientists are taking what they've learned from their multicenter research collaboration studying the health impact of fatty acids on diverse populations to set up a genetics center in India.

8 Nov 2012

Early clues regarding progression of Alzheimer's disease found in brain's metabolism

When it comes to Alzheimer's disease, scientists usually - and understandably - look to the brain as their first center of attention. Now researchers at Tel Aviv University say that early clues regarding the progression of the disease can be found in the brain's metabolism.

8 Nov 2012

New understanding of how noise can break critical tip link protein structure in inner ear cells

Researchers have mapped the precise 3-D atomic structure of a thin protein filament critical for cells in the inner ear and calculated the force necessary to pull it apart.

8 Nov 2012

Autologous stem cells do not improve heart function when given three weeks after heart attack

Administering stem cells derived from patients' own bone marrow either three or seven days after a heart attack is safe but does not improve heart function six months later, according to a clinical trial supported by the National Institutes of Health (NIH).

8 Nov 2012

ACS Prized Science video features advances in personalized medicine

Personalized medicine - the promise of customizing treatments that will work best for each individual patient - could get a boost from advances in understanding how the proteins that help determine health and disease take the three-dimensional shapes needed to work in the body. That's the message of the latest episode of the 2012 edition of a popular video series from the American Chemical Society (ACS), the world's largest scientific society.

8 Nov 2012

Researchers simulate activity of cultured neural networks

After a short period of growth, cultured networks of neurons regularly exhibit major activity in the absence of external stimulation. These "bursts" are entirely related to growth. At this stage, they have little to do with learning behaviour, as the network is still too young to sustain a process of memory formation. This has now for the first time been simulated for networks ranging in size from 10,000 to 50,000 neurons. The simulations provide insight into the role of the growth process in initial activity.

8 Nov 2012

Stapled Peptide oncology drug candidate exhibits robust efficacy in xenograft cancer models

Aileron Therapeutics, Inc. and its collaborator Roche today announced new results of a preclinical study of its Stapled Peptide oncology drug candidate ATSP-7041, which exhibited robust efficacy in MDM2 and MDMX xenograft cancer models.

8 Nov 2012

Simple biomarker model to predict heart failure risk

The most widely used models for predicting heart failure rely on a complex combination of lifestyle, demographic, and cardiovascular risk factor information.

8 Nov 2012

Nanofiber technique to build new nerves from stem cells

Every week in his clinic at the University of Michigan, neurologist Joseph Corey, M.D., Ph.D., treats patients whose nerves are dying or shrinking due to disease or injury.

8 Nov 2012

University of Tübingen heads Neuromics consortium

Work has begun on Neuromics, a major project headed by Tübingen's Professor Olaf Riess; the project beat out ten other first-class applications to attain €12m euros in EU funding over five years.

8 Nov 2012

U-M to improve disease diagnosis through metabolic profiling

The University of Michigan Health System has earned a $9.1 million core grant from the National Institutes of Health to improve disease diagnosis through metabolic profiling.

8 Nov 2012

Two new EU Member States now represented within TRANSVAC services platform

In addition to the initial panel of nine services, the TRANSVAC transnational access platform has integrated in July 2012 five additional groups which provide their services to users on a free and paid basis. Two new European Union (EU) Member States are now represented within the platform of services: France and Portugal.

8 Nov 2012

Studies provide first clues of balanced de novo chromosomal rearrangements

Whole genome sequencing of the DNA code of three prenatal samples provided a detailed map of the locations of their chromosomal abnormalities in 14 days, scientists reported today at the American Society of Human Genetics (ASHG) 2012 meeting in San Francisco.

8 Nov 2012

Scientists develop measures to prevent health problems associated with biogenic amines in wine

Biogenic amines may be one of the factors responsible for symptoms such as headaches, gastro-intestinal disorders, shortness of breath, fall in blood pressure, and even unconsciousness and cardiac arrhythmia in severe cases. Histamine, one of the best known members of this group, can cause serious physical problems. Biogenic amines can be produced in the body by natural metabolic activities but are also ingested in larger quantities with food.

8 Nov 2012

New UTSW model can predict progression of skin cancer in patients

UT Southwestern Medical Center scientists led by Dr. Sean Morrison, director of the Children's Medical Center Research Institute at UT Southwestern, have developed an innovative model for predicting the progression of skin cancer in patients.

8 Nov 2012

In silico drug design may lead to new approach in treatment of Alzheimer's

Researchers at Dalhousie University have discovered a new technique using "computer-aided" drug design that may lead to an entirely new approach in the treatment of Alzheimer's disease (AD).

8 Nov 2012

Researchers discover cellular pathway that causes lung-damaging inflammation in CF

Vancouver researchers have discovered the cellular pathway that causes lung-damaging inflammation in cystic fibrosis (CF), and that reducing the pathway's activity also decreases inflammation.

8 Nov 2012

Brain switches into special mode when pushed to make rapid decisions

Why do our brains make more mistakes when we act quickly? A new study demonstrates how the brain follows Ben Franklin's famous dictum, "Take time for all things: great haste makes great waste."

8 Nov 2012

UC Irvine researchers create new stem cell-derived cell type for treatment of Alzheimer's

UC Irvine researchers have created a new stem cell-derived cell type with unique promise for treating neurodegenerative diseases such as Alzheimer's.

8 Nov 2012

Calcium intake does not increase risk of coronary artery calcification

Researchers at the Institute for Aging Research (IFAR) at Hebrew SeniorLife, an affiliate of Harvard Medical School (HMS), have published a study that shows no evidence of a link between calcium intake and coronary artery calcification, reassuring adults who take calcium supplements for bone health that the supplements do not appear to result in the development of calcification of blood vessels.

8 Nov 2012

Medical Science News

Study on genetic capacity of diverse populations to make critical PUFAs

Early clues regarding progression of Alzheimer's disease found in brain's metabolism

New understanding of how noise can break critical tip link protein structure in inner ear cells

Autologous stem cells do not improve heart function when given three weeks after heart attack

ACS Prized Science video features advances in personalized medicine

Researchers simulate activity of cultured neural networks

Stapled Peptide oncology drug candidate exhibits robust efficacy in xenograft cancer models

Simple biomarker model to predict heart failure risk

Nanofiber technique to build new nerves from stem cells

University of Tübingen heads Neuromics consortium

U-M to improve disease diagnosis through metabolic profiling

Two new EU Member States now represented within TRANSVAC services platform

Studies provide first clues of balanced de novo chromosomal rearrangements

Scientists develop measures to prevent health problems associated with biogenic amines in wine

New UTSW model can predict progression of skin cancer in patients

In silico drug design may lead to new approach in treatment of Alzheimer's

Researchers discover cellular pathway that causes lung-damaging inflammation in CF

Brain switches into special mode when pushed to make rapid decisions

UC Irvine researchers create new stem cell-derived cell type for treatment of Alzheimer's

Calcium intake does not increase risk of coronary artery calcification

The CAR T Veteran: A Journey of Resilience, Remission, and Advocacy

Innovating for impact: Jordi Labs on aligning methodologies with FDA expectation

Exploring the role of confocal-based high-content imaging in advancing core facilities

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