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Cedars-Sinai scientist to study potential treatments for AD

A Cedars-Sinai research scientist has been awarded two national grants totaling more than $2.5 million, including a prestigious Research Project Grant from the National Institutes of Health to study potential treatments for Alzheimer's disease.

21 Feb 2012

Researchers discover new evidence on how cholesterol transfers from HDLs to LDLs

Researchers with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab) have found new evidence to explain how cholesteryl ester transfer protein (CETP) mediates the transfer of cholesterol from "good" high density lipoproteins (HDLs) to "bad" low density lipoproteins.

21 Feb 2012

University of Pennsylvania, IMUC enter license agreement for dendritic-cell production method

ImmunoCellular Therapeutics today announced that it has entered into an agreement with the University of Pennsylvania under which University of Pennsylvania has granted the Company an exclusive, worldwide license for a patent pending technology for the production of high-activity dendritic cells.

21 Feb 2012

Xencor, Boehringer Ingelheim partner to develop and supply biosuperior monoclonal antibodies

Xencor, Inc., a company using its proprietary Protein Design Automation (PDA) platform technology to engineer next-generation antibodies, and Boehringer Ingelheim announced today a collaboration agreement for certain Xencor biosuperior monoclonal antibodies.

21 Feb 2012

Tasmanian devil cancer genome mapped

Researchers, including those from Wellcome Trust Sanger Institute near Cambridge, have sequenced the genome of a facial cancer that is threatening the existence of the Tasmanian devil.

21 Feb 2012

Genomic instability allows malignant cells to acquire more deadly characteristics

Genomic instability caused by an erosion of the protective caps on chromosomes, followed by activation of an enzyme that reinforces those aps, allows malignant cells to evade destruction and acquire more deadly characteristics, researchers report in an Online Now article at the journal Cell.

21 Feb 2012

Precision BioSciences sues Cellectis over engineered meganucleases patent infringement

Precision BioSciences, Inc., a leader in the field of genome engineering, today announced that it has filed two patent infringement lawsuits against Cellectis SA and a number of its affiliates in the U.S. District Court for the Eastern District of North Carolina.

21 Feb 2012

Telomerase reactivation in malignant cells after genomic instability causes cancer progression

Inhibiting telomerase, an enzyme that rescues malignant cells from destruction by extending the protective caps on the ends of chromosomes, kills tumor cells but also triggers resistance pathways that allow cancer to survive and spread, scientists report in the Feb. 17 issue of Cell.

21 Feb 2012

Gene that destroys cancerous cells also causes ageing

The role of one of our genes which protects us from cancer but could also cause us to age will be explained in a lecture at the University of Leicester.

21 Feb 2012

Researchers discover identical antibiotic resistant genes in soil bacteria and in pathogens from clinics

Disease-causing bacteria's efforts to resist antibiotics may get help from their distant bacterial relatives that live in the soil, new research at Washington University School of Medicine suggests.

21 Feb 2012

Targeting patient's own dendritic cells may help restore the immune system

Aggressive ovarian tumors begin as malignant cells kept in check by the immune system until, suddenly and unpredictably, they explode into metastatic cancer. New findings from scientists at The Wistar Institute demonstrate that ovarian tumors don't necessarily break "free" of the immune system, rather dendritic cells of the immune system seem to actively support the tumor's escape.

20 Feb 2012

KI's chemical interaction map shows how inhibitors bind to PARP enzymes

A team of researchers at Karolinska Institutet in Sweden has generated a map over the effects of small drug-like molecules on PARP1 and other similar proteins in the body. This map may explain the mechanism behind putative side effects of the so-called PARP inhibitors, and can play an important role in the development of novel tailor-made cancer drugs.

20 Feb 2012

ASI receives FDA clearance for GenASIs Scan and Analysis

Applied Spectral Imaging (ASI) announces that ASI's GenASIs automated scanning and image analysis system for detection and quantifying chromosome 17 and the HER-2/neu gene has been cleared by the United States Food and Drug Administration (FDA) for marketing in the US.

20 Feb 2012

DNA ‘nanorobot’ effectively targets cancer leaving healthy cells untouched: Study

Researchers have developed ‘nano-sized’ probes built from DNA that can seek and destroy cancer cells, leaving healthy cells untouched. These ‘nanorobots’ release their drug payload only when they reach and identify their target and are believed to improve many treatments for disease.

20 Feb 2012

EC approves Plexxikon's Zelboraf to treat BRAF mutation-positive MM

Plexxikon Inc., a member of Daiichi Sankyo Group, today announced that the European Commission has approved Zelboraf (vemurafenib) for the monotherapy treatment of adult patients with BRAFV600 mutation-positive unresectable or metastatic melanoma.

20 Feb 2012

Researchers track structural changes during formation of new memories

New connections between brain cells emerge in clusters in the brain as animals learn to perform a new task, according to a study published in Nature on February 19 (advance online publication). Led by researchers at the University of California, Santa Cruz, the study reveals details of how brain circuits are rewired during the formation of new motor memories.

20 Feb 2012

Study identifies USP15 as a critical protein in cancer

After years studying the molecular bases of glioblastoma - the most common brain tumor and one of the most aggressive of all cancers, the group led by Dr. Joan Seoane , Director of Translational Research at the Vall d'Hebron Institute of Oncology (VHIO) and ICREA Research Professor has today published a study in Nature Medicine identifying USP15 as a critical protein in cancer which, thanks to its molecular characteristics, shows enormous therapeutic promise.

20 Feb 2012

Modified imatinib cancer drug prevents morphine tolerance in rats

By reformulating the common cancer drug imatinib (Gleevec), researchers have eliminated morphine tolerance in rats - an important step toward improving the effectiveness of chronic pain management in patients, according to researchers at The University of Texas MD Anderson Cancer Center.

20 Feb 2012

ESOF 2012 science program launches today at AAAS meeting in Vancouver

The science program for Euroscience Open Forum 2012 (ESOF 2012) was officially launched today at the AAAS meeting in Vancouver.

20 Feb 2012

Symposium discusses links between genetic, epigenetic and environmental influences on autism

Two UC Davis MIND Institute researchers will lead a symposium on relationships between genetic, epigenetic and environmental influences on the development of autism in children during the American Association for the Advancement of Science (AAAS) Annual Meeting, Feb. 16 -18 in Vancouver, Canada.

20 Feb 2012

Medical Science News

Cedars-Sinai scientist to study potential treatments for AD

Researchers discover new evidence on how cholesterol transfers from HDLs to LDLs

University of Pennsylvania, IMUC enter license agreement for dendritic-cell production method

Xencor, Boehringer Ingelheim partner to develop and supply biosuperior monoclonal antibodies

Tasmanian devil cancer genome mapped

Genomic instability allows malignant cells to acquire more deadly characteristics

Precision BioSciences sues Cellectis over engineered meganucleases patent infringement

Telomerase reactivation in malignant cells after genomic instability causes cancer progression

Gene that destroys cancerous cells also causes ageing

Researchers discover identical antibiotic resistant genes in soil bacteria and in pathogens from clinics

Targeting patient's own dendritic cells may help restore the immune system

KI's chemical interaction map shows how inhibitors bind to PARP enzymes

ASI receives FDA clearance for GenASIs Scan and Analysis

DNA ‘nanorobot’ effectively targets cancer leaving healthy cells untouched: Study

EC approves Plexxikon's Zelboraf to treat BRAF mutation-positive MM

Researchers track structural changes during formation of new memories

Study identifies USP15 as a critical protein in cancer

Modified imatinib cancer drug prevents morphine tolerance in rats

ESOF 2012 science program launches today at AAAS meeting in Vancouver

Symposium discusses links between genetic, epigenetic and environmental influences on autism

Exploring the role of confocal-based high-content imaging in advancing core facilities

Transforming Cardiovascular Care: Insights from Mina Makar at AstraZeneca

Clue's CEO Rhiannon White on the Future of Femtech and PCOS

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