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New cell and animal model of IBC

Inflammatory breast cancer (IBC) is a very aggressive, often misunderstood type of cancer that is diagnosed more frequently in younger women compared with other types of breast cancer. The five-year survival rate is between 25 and 50 percent-significantly lower than the survival rate for other types of breast cancer. The reason for the poor prognosis is that IBC usually grows rapidly and often spreads quickly to other parts of the body, including the brain, bone and lymph nodes.

5 Apr 2012

Fathers more likely to transmit spontaneous mutations to children with ASDs

Researchers have turned up a new clue to the workings of a possible environmental factor in autism spectrum disorders (ASDs): fathers were four times more likely than mothers to transmit tiny, spontaneous mutations to their children with the disorders. Moreover, the number of such transmitted genetic glitches increased with paternal age. The discovery may help to explain earlier evidence linking autism risk to older fathers.

5 Apr 2012

Scientists image process of consciousness after general anesthesia

Awakening from anesthesia is often associated with an initial phase of delirious struggle before the full restoration of awareness and orientation to one's surroundings. Scientists now know why this may occur: primitive consciousness emerges first. Using brain imaging techniques in healthy volunteers, a team of scientists led by Adjunct Professor Harry Scheinin, M.D. from the University of Turku, Turku, Finland in collaboration with investigators from the University of California, Irvine, USA, have now imaged the process of returning consciousness after general anesthesia.

5 Apr 2012

Scientists uncover structure and operating mechanism of TPPII

Uncontrolled or inaccurate degradation of cellular proteins can lead to diseases like cancer or Alzheimer's disease. Scientists of the Max Planck Institute of Biochemistry (MPIB) in Martinsried near Munich, Germany, have now uncovered the structure and the operating mechanism of an important component of the human cellular degradation machinery, tripeptidyl peptidase II.

5 Apr 2012

Feinstein scientists to present three GBM abstracts at AACR annual meeting

Scientists from the Feinstein Institute for Medical Research will present three abstracts about Glioblastoma multiforme (GBM), the most common and deadly adult brain cancer, at the American Association for Cancer Research (AACR) Annual Meeting to be held from Saturday through Wednesday (March 31- April 4) in Chicago, IL.

5 Apr 2012

Scripps Florida scientists to create new screening tests for HCV treatment discovery

Scientists from the Florida campus of The Scripps Research Institute have been awarded just over $1 million from the National Institutes of Health for a three-year study to develop new high-throughput screening tests to find compounds that disable a protein essential to hepatitis C virus (HCV) replication.

5 Apr 2012

µ-PIIIA conotoxin can be effective in controlling cancer pain

Hidden in the mud, the cone snail Conus purpurascens lies in wait for its victims. It attracts its prey, fish, with its proboscis, which can move like a worm, protruding from the mud. Once a fish approaches out of curiosity, the snail will rapidly shoot a harpoon at it, which consists of an evolutionarily modified tooth. The paralyzed victim then becomes an easy meal. It takes the venomous cone snail about two weeks to digest a fish. During this time, its venomous harpoon is also replaced.

5 Apr 2012

Walter and Eliza Hall Institute researchers receive five ASBMB awards

Walter and Eliza Hall Institute researchers have received five of the 11 awards for excellence in biochemistry and microbiology announced by the Australian Society of Biochemistry and Molecular Biology (ASBMB) this month.

5 Apr 2012

More than 4 in 10 people at high risk for hereditary pancreatic cancer have small lesions

A team of scientists led by Johns Hopkins researchers have found that more than four in 10 people considered at high risk for hereditary pancreatic cancer have small pancreatic lesions long before they have any symptoms of the deadly disease.

5 Apr 2012

Brain games, exercise and diet help prevent cognitive slide

Exercising, eating a healthy diet and playing brain games may help you keep your wits about you well into your 80s and even 90s, advises a new book by researchers at George Mason University.

5 Apr 2012

Olanzapine improves survival in mouse model of anorexia nervosa

Low doses of a commonly used atypical antipsychotic drug improved survival in a mouse model of anorexia nervosa, University of Chicago researchers report this month. The result offers promise for a common and occasionally fatal eating disorder that currently lacks approved drugs for treatment.

5 Apr 2012

Researchers uncover mechanism that explains link between autoimmunity and atherosclerosis

Patients with autoimmune diseases often show a predisposition to develop "hardening of the arteries" or atherosclerosis. LMU researchers have now uncovered a mechanism that establishes a causal link between the two disorders.

5 Apr 2012

New SORL1 gene causes early-onset Alzheimer's

A new gene that causes early-onset of Alzheimer's disease has been discovered by the research team of Dominique Campion at the Insert unit 1079 "Genetics of cancer and neuropsychiatric diseases" in Rouen.

5 Apr 2012

Exposure to arsenic can turn normal stem cells into cancer stem cells

Researchers at the National Institutes of Health have discovered how exposure to arsenic can turn normal stem cells into cancer stem cells and spur tumor growth. Inorganic arsenic, which affects the drinking water of millions of people worldwide, has been previously shown to be a human carcinogen.

4 Apr 2012

Reactivation of p53 may be a highly selective treatment modality for virally-induced lymphoma

Kaposi's sarcoma herpesvirus (KSHV) is a human tumor virus and an etiological agent for Kaposi's sarcoma and primary effusion lymphoma (PEL). PELs are aggressive lymphomas with reported median survival time shorter than six months after diagnosis.

4 Apr 2012

Drugs that target cholesterol pathway may enhance cancer-killing potential of chemotherapy drugs

Johns Hopkins investigators are testing a way to use drugs that target a cholesterol pathway to enhance the cancer-killing potential of standard chemotherapy drugs. Their tests, in mouse models of pancreatic cancer, may yield new and more effective combinations of current and possibly new anti-cancer drugs.

4 Apr 2012

Altered activity at different sites within brain network may be related to different features of depression

Depressed individuals with a tendency to ruminate on negative thoughts, i.e. to repeatedly think about particular negative thoughts or memories, show different patterns of brain network activation compared to healthy individuals, report scientists of a new study in Biological Psychiatry.

4 Apr 2012

Impact of Personal Genomics Study to launch data collection phase

As genetic risk information plays an increasingly important role in the diagnosis and treatment of many diseases, private companies have made personal genomic testing for these risk factors widely available to the public. However, very little data has been gathered to understand the motivations and expectations of consumers of personal genomic services, the psychological and behavioral impact of these services, and the associated ethical, legal and social issues—until now.

4 Apr 2012

Study: Functional link between two major causes of treatment failure in breast cancer

Research from The Cancer Institute of New Jersey (CINJ) shows a functional link between two major causes of treatment failure in breast cancer, showing the protein behind one of these causes plays a role in increasing the drug resistance properties of the other.

4 Apr 2012

Researchers identify how neural cells build up resistance to opioid pain drugs within hours

Researchers at the University of Montreal's Sainte-Justine Hospital have identified how neural cells are able to build up resistance to opioid pain drugs within hours. "A better understanding of these mechanisms will enable us to design drugs that avoid body resistance to these drugs and produce longer therapeutic responses, including prolonged opioid analgesia", lead author Dr. Graciela Pineyro said.

4 Apr 2012

Medical Science News

New cell and animal model of IBC

Fathers more likely to transmit spontaneous mutations to children with ASDs

Scientists image process of consciousness after general anesthesia

Scientists uncover structure and operating mechanism of TPPII

Feinstein scientists to present three GBM abstracts at AACR annual meeting

Scripps Florida scientists to create new screening tests for HCV treatment discovery

µ-PIIIA conotoxin can be effective in controlling cancer pain

Walter and Eliza Hall Institute researchers receive five ASBMB awards

More than 4 in 10 people at high risk for hereditary pancreatic cancer have small lesions

Brain games, exercise and diet help prevent cognitive slide

Olanzapine improves survival in mouse model of anorexia nervosa

Researchers uncover mechanism that explains link between autoimmunity and atherosclerosis

New SORL1 gene causes early-onset Alzheimer's

Exposure to arsenic can turn normal stem cells into cancer stem cells

Reactivation of p53 may be a highly selective treatment modality for virally-induced lymphoma

Drugs that target cholesterol pathway may enhance cancer-killing potential of chemotherapy drugs

Altered activity at different sites within brain network may be related to different features of depression

Impact of Personal Genomics Study to launch data collection phase

Study: Functional link between two major causes of treatment failure in breast cancer

Researchers identify how neural cells build up resistance to opioid pain drugs within hours

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