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Stem cells from own bone marrow improve heart function

A research network led by a Mayo Clinic physician found that stem cells derived from heart failure patients' own bone marrow and injected into their hearts improved the function of the left ventricle, the heart's pumping chamber. Researchers also found that certain types of the stem cells were associated with the largest improvement and warrant further study.

26 Mar 2012

Synthetic pasta-like objects are major chemistry advances for regenerative medicine

Medicine's recipe for keeping older people active and functioning in their homes and workplaces - and healing younger people injured in catastrophic accidents - may include "noodle gels" and other lab-made invisible filaments that resemble uncooked spaghetti with nanoscale dimensions, a scientist said here today at the 243rd National Meeting & Exposition of the American Chemical Society (ACS).

26 Mar 2012

Commensal bacteria may play an important role in influencing and controlling allergic inflammation

When poet Walt Whitman wrote that we "contain multitudes," he was speaking metaphorically, but he was correct in the literal sense. Every human being carries over 100 trillion individual bacterial cells within the intestine -- ten times more cells than comprise the body itself.

26 Mar 2012

Previously unknown mechanism helps intestinal bacteria to affect formation of blood vessels

Researchers at the Sahlgrenska Academy at the University of Gothenburg, Sweden, have discovered a previously unknown mechanism which helps intestinal bacteria to affect the formation of blood vessels. The results, which are presented in Nature, may provide future treatments of intestinal diseases and obesity.

26 Mar 2012

Switch may release fuel and materials for rapid growth and formation of layers that later become organs

Shortly after a mouse embryo starts to form, some of its stem cells undergo a dramatic metabolic shift to enter the next stage of development, Seattle researchers report today. These stem cells start using and producing energy like cancer cells.

26 Mar 2012

Largest study to date to look at BMC therapy in patients with heart failure

Use of a patient's bone marrow cells for treating chronic ischemic heart failure did not result in improvement on most measures of heart function, according to a study appearing in JAMA. The study is being published early online to coincide with its presentation at the American College of Cardiology's annual scientific sessions.

26 Mar 2012

New advance in ability to target and destroy certain cancer cells

An international team of scientists has announced a new advance in the ability to target and destroy certain cancer cells. A group led by the University of Leicester has shown that particular cancer cells are especially sensitive to a protein called p21. This protein usually forces normal and cancer cells to stop dividing but it was recently shown that in some cases it can also kill cancer cells.

26 Mar 2012

High-fat, low-carb foods linked with increased risk of heart attack in obese people

High-fat, low-carb foods are a popular choice for dieters, but new laboratory research by University of Alabama at Birmingham cardiologists indicates these may be detrimental to the health of people who have ischemic cardiovascular disease or a predisposition to heart attacks.

26 Mar 2012

Testosterone receptor may be a potential target for triple negative breast cancer

Could blocking a testosterone receptor lead to a new way to treat an aggressive form of breast cancer? That's a question researchers at Mayo Clinic in Arizona and the Translational Genomics Research Institute (TGen) are exploring. Preliminary results of a Mayo Clinic - TGen collaborative study shows the testosterone receptor may be a potential target to attack in treating triple negative breast cancer (TNBC).

26 Mar 2012

Study reveals central role played by DBIRD protein complex in gene transcription

In a study published this week in the journal Nature, researchers at the University of Liège's GIGA Unit, together with English and German teams, reveal the central role played by a protein complex, unknown up to now, in gene transcription.

26 Mar 2012

Bacteriophages can tackle drug-resistant bacterial infections

Viruses that can target and destroy bacteria have the potential to be an effective strategy for tackling hard-to-treat bacterial infections. The development of such novel therapies is being accelerated in response to growing antibiotic resistance, says Dr David Harper at the Society for General Microbiology's Spring Conference in Dublin.

26 Mar 2012

Strong link between telomere shortening and heart disease risk

No one really wants the short end of the stick, in this case the short end of a chromosome. Telomeres, which are DNA-protein complexes at the ends of chromosomes, can be thought of as protein "caps" that protect chromosomes from deteriorating and fusing with neighboring chromosomes.

26 Mar 2012

Study validates Mitofusin 2 as possible target for treatment of diabetes mellitus

Researchers at the Institute for Research in Biomedicine (IRB Barcelona) have discovered that deficiency of a single protein, Mitofusin 2, in muscle and hepatic cells of mice is sufficient to cause tissues to become insensitive to insulin, thus producing an increase in blood glucose concentrations. These are the two most common conditions prior to development of diabetes type 2.

26 Mar 2012

Cathepsin Z protein regulates metastasis of pancreatic cancer

Researchers at Queen Mary, University of London have identified a new protein that makes pancreatic cancer cells less 'sticky' and therefore less able to attach to and invade other tissue.

26 Mar 2012

Insulin resistance occurs in the brains of people with Alzheimer's

Insulin resistance in the brain precedes and contributes to cognitive decline above and beyond other known causes of Alzheimer's disease, according to a new study by researchers from the Perelman School of Medicine at the University of Pennsylvania. Insulin is an important hormone in many bodily functions, including the health of brain cells.

26 Mar 2012

S. gordonii may trigger infective endocarditis

Oral bacteria that escape into the bloodstream are able to cause blood clots and trigger life-threatening endocarditis. Further research could lead to new drugs to tackle infective heart disease, say scientists presenting their work at the Society for General Microbiology's Spring Conference in Dublin this week.

26 Mar 2012

Metformin can have protective effects on the heart

The widely used diabetes medicine metformin can have protective effects on the heart, reveals a new study conducted at the Sahlgrenska Academy, at the University of Gothenburg, Sweden.

26 Mar 2012

New IVIG trial can reduce OCD symptoms in children with PANDAS

Criteria for a broadened syndrome of acute onset obsessive compulsive disorder (OCD) have been proposed by a National Institutes of Health scientist and her colleagues. The syndrome, Pediatric Acute-onset Neuropsychiatric Syndrome (PANS), includes children and teens that suddenly develop on-again/off-again OCD symptoms or abnormal eating behaviors, along with other psychiatric symptoms - without any known cause.

26 Mar 2012

New method for measurement of aggregated beta-amyloid in AD

An international team of researchers have developed a new method for measurement of aggregated beta-amyloid - a protein complex believed to cause major nerve cell damage and dysfunction in Alzheimer's disease. The new method might facilitate diagnosis and detection as well as development of drugs directed against aggregated beta-amyloid.

26 Mar 2012

GenVec announces data from respiratory syncytial virus vaccine program

GenVec, Inc. (Nasdaq: GNVC) announced today that data were presented on GenVec's respiratory syncytial virus (RSV) vaccine program at the "Keystone Symposium on Viral Immunity and Host Gene Influence", which is taking place in Keystone, Colorado from March 21-26, 2012.

26 Mar 2012

Medical Science News

Stem cells from own bone marrow improve heart function

Synthetic pasta-like objects are major chemistry advances for regenerative medicine

Commensal bacteria may play an important role in influencing and controlling allergic inflammation

Previously unknown mechanism helps intestinal bacteria to affect formation of blood vessels

Switch may release fuel and materials for rapid growth and formation of layers that later become organs

Largest study to date to look at BMC therapy in patients with heart failure

New advance in ability to target and destroy certain cancer cells

High-fat, low-carb foods linked with increased risk of heart attack in obese people

Testosterone receptor may be a potential target for triple negative breast cancer

Study reveals central role played by DBIRD protein complex in gene transcription

Bacteriophages can tackle drug-resistant bacterial infections

Strong link between telomere shortening and heart disease risk

Study validates Mitofusin 2 as possible target for treatment of diabetes mellitus

Cathepsin Z protein regulates metastasis of pancreatic cancer

Insulin resistance occurs in the brains of people with Alzheimer's

S. gordonii may trigger infective endocarditis

Metformin can have protective effects on the heart

New IVIG trial can reduce OCD symptoms in children with PANDAS

New method for measurement of aggregated beta-amyloid in AD

GenVec announces data from respiratory syncytial virus vaccine program

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