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Molecular secrets behind halofuginone's power

For roughly two thousand years, Chinese herbalists have treated Malaria using a root extract, commonly known as Chang Shan, from a type of hydrangea that grows in Tibet and Nepal. More recent studies suggest that halofuginone, a compound derived from this extract's bioactive ingredient, could be used to treat many autoimmune disorders as well. Now, researchers from the Harvard School of Dental Medicine have discovered the molecular secrets behind this herbal extract's power.

13 Feb 2012

KSU, St. Michael's receive U.S. patent to use BRCA1 gene for cardiovascular disease

St. Michael's Hospital and King Saud University have received their first joint U.S. patent to use the BRCA1 gene as a therapy for cardiovascular disease.

13 Feb 2012

Curcumin may block growth of castrate-resistant prostate tumors

Curcumin, an active component of the Indian curry spice turmeric, may help slow down tumor growth in castration-resistant prostate cancer patients on androgen deprivation therapy (ADT), a study from researchers at Jefferson's Kimmel Cancer Center suggests.

13 Feb 2012

First study to ever quantify effects of estrogen as a stimulant of pheromones

A new study has shown that boosting the estrogen levels of male garter snakes causes them to secrete the same pheromones that females use to attract suitors, and turned the males into just about the sexiest snake in the neighborhood - attracting dozens of other males eager to mate.

13 Feb 2012

Research team studies effect of anabolic steroids on body fat

A research team at Luleå University of Technology and Umea University has, in a unique study involving ten Swedish elite lifters who are actively using anabolic steroids, studied the effect of Anabolic steroids on body fat. Swedish elite lifters who use anabolic steroids have more dangerous fat distribution in the body.

12 Feb 2012

Study reveals how SAMHD1 works to protect dendritic cells from HIV virus

A novel discovery by researchers at NYU Langone Medical Center and colleagues reveals a mechanism by which the immune system tries to halt the spread of HIV. Harnessing this mechanism may open up new paths for therapeutic research aimed at slowing the virus' progression to AIDS. The study appears online ahead of print today in Nature Immunology.

12 Feb 2012

Study investigates how cytokine IFN-λ release is regulated

In new research appearing in this month's issue of the journal Nature Immunology, Roy Curtiss, director of the Center for Infectious Diseases and Vaccinology at the Biodesign Institute at Arizona State University, along with international collaborators, investigates the coordination of a particular type of immune response, involving the release of of IFN-λ- a cell-signaling protein molecule known as a cytokine.

10 Feb 2012

Scientists discover ferocity of immune system after viral infection

A scientific team led by researchers at the University of Geneva (UNIGE) and the Charité Berlin Medical University has made a completely unprecedented discovery showing how much our immune system is provoked into action when confronted by viral intruders.

10 Feb 2012

Scientists identify single prion protein that causes neuronal death

Scientists from the Florida campus of The Scripps Research Institute have identified a single prion protein that causes neuronal death similar to that seen in "mad cow" disease, but is at least 10 times more lethal than larger prion species.

10 Feb 2012

Genomics pioneer to present at ARVO 2012 meeting

The Association for Research in Vision and Ophthalmology is pleased to welcome J. Craig Venter as the keynote speaker at the opening session of ARVO 2012 on Sunday, May 6 in Fort Lauderdale, Fla. Venter's presentation is entitled "From Reading to Writing the Genetic Code."

10 Feb 2012

New evidence for role of the brain in obesity

Researchers at the University of Turku and Aalto University have now found new evidence for the role of the brain in obesity. The researchers measured the functioning brain circuits involved in with multiple brain imaging methods.

10 Feb 2012

Gene therapy to promote remyelination in mouse model of MS

Our bodies are full of tiny superheroes-antibodies that fight foreign invaders, cells that regenerate, and structures that ensure our systems run smoothly. One such structure is myelin-a material that forms a protective, insulating cape around the axons of our nerve cells so that they can send signals quickly and efficiently. But myelin, and the specialized cells called oligodendrocytes that make it, become damaged in demyelinating diseases like multiple sclerosis (MS), leaving neurons without their myelin sheaths.

10 Feb 2012

UofL to receive Grand Challenges tuberculosis biomarkers grant

The University of Louisville announced today that it will receive a tuberculosis (TB) biomarkers grant through the Bill & Melinda Gates Foundation's Grand Challenges in Global Health program, an initiative which seeks to overcome persistent bottlenecks in creating new tools that can radically improve health in the developing world. James E. Graham, Ph.D., associate professor of microbiology and immunology at the UofL School of Medicine, will pursue an innovative research project to identify and validate TB biomarkers, titled "Disposable Sampling Plate and Breath Test to Identify Patients with Active Tuberculosis."

10 Feb 2012

New 3D computer model to understand cancer development

Observing that certain cancer cells may exhibit greater flexibility than normal cells, some scientists believe that this capability promotes rapid tumor growth. Now computer simulations developed by Boston University Biomedical Engineering Assistant Professor Muhammad Zaman and collaborators at the University of Texas at Austin appear to support this view.

10 Feb 2012

Forsyth Institute to receive TB biomarkers grant from Gates Foundation

The Forsyth Institute announced today that it will receive a tuberculosis (TB) biomarkers grant through the Bill & Melinda Gates Foundation's Grand Challenges in Global Health program, an initiative which seeks to overcome persistent bottlenecks in creating new tools that can radically improve health in the developing world.

10 Feb 2012

Injecting MWCNTs can kill tumor initiating breast cancer stem cells

Wake Forest Baptist Medical Center researchers have again proven that injecting multiwalled carbon nanotubes (MWCNTs) into tumors and heating them with a quick, 30-second laser treatment can kill them.

10 Feb 2012

IKBKE protein plays two roles in tobacco-related NSCLC

Researchers at Moffitt Cancer Center in Tampa, Fla., have discovered that the immune response regulator IKBKE (serine/threonine kinase) plays two roles in tobacco-related non-small cell lung cancers. Tobacco carcinogens induce IKBKE and, in turn, IKBKE induces chemotherapy resistance.

10 Feb 2012

U-M research sheds light on aging process

Beauty is more than skin deep, at least for fruit flies studied in new research that demonstrates how age-related changes in pheromone production can reduce sexual attractiveness.

10 Feb 2012

Study identifies new gene variants linked with risk of T2D

The largest genetics study to date of type 2 diabetes (T2D) has identified new gene variants associated with risk for the common metabolic disease. An international scientific consortium, studying multiethnic populations, uncovered genes that may point to biological targets for developing more effective drugs for T2D.

10 Feb 2012

SomaLogic to receive TB biomarkers grant from Gates Foundation

SomaLogic, Inc., announced today that it will receive a tuberculosis (TB) biomarkers grant through the Bill & Melinda Gates Foundation's Grand Challenges in Global Health program, an initiative that seeks to overcome persistent bottlenecks in creating new tools that can radically improve health in the developing world.

10 Feb 2012