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Achievement of pre-clinical milestone triggers $4M payment from GSK to Epizyme

Epizyme, Inc., a company leading the discovery and development of personalized therapeutics for genetically-defined cancer patients, today announced the achievement of pre-clinical milestones in its alliance with GlaxoSmithKline (GSK), triggering $4 million in milestone payments.

15 Oct 2011

Exercise stimulates two beneficial proteins in women before and during pregnancy

Although exercise is generally considered to be a good thing for people with high blood pressure, it has traditionally been considered too risky for women who are also pregnant. Some studies suggest that exercise has benefits such as decreasing the risk of women developing preeclampsia, a condition that raises blood pressure to dangerously high levels but how this might happen has remained unknown.

15 Oct 2011

Virtual brain models for epilepsy and schizophrenia

Virtual brains modeling epilepsy and schizophrenia display less complexity among functional connections, and other differences compared to healthy brain models, researchers at Case Western Reserve University School of Medicine report.

15 Oct 2011

Scientists uncover vast new gene regulatory network linked with cancer

Researchers at Columbia University Medical Center (CUMC) and two other institutions have uncovered a vast new gene regulatory network in mammalian cells that could explain genetic variability in cancer and other diseases.

15 Oct 2011

Scientists reveal how resistance to hormone leptin develops

The effects of obesity - both on our bodies and on the health budget - are well known, and now, scientists are getting closer to understanding how the disease progresses, providing clues for future treatments.

15 Oct 2011

Brain stem cell treatment for multiple sclerosis

The prospect of doing human clinical trials with stem cells to treat diseases like multiple sclerosis may be growing closer, say scientists at the University at Buffalo and the University at Rochester, who have developed a more precise way to isolate stem cells that will make myelin.

15 Oct 2011

NextBio predicts mechanisms underlying drug toxicity and identifies new cancer biomarker

New research presented this week highlights the ability of NextBio to help life scientists and clinicians investigate publicly available genomic data to assess biological mechanisms underlying drug toxicity, as well as discover prospective cancer biomarkers for further validation.

15 Oct 2011

Engineered HBLs could prevent deadly allergic reactions

Researchers from the University of Notre Dame have announced a breakthrough approach to allergy treatment that inhibits food allergies, drug allergies, and asthmatic reactions without suppressing a sufferer's entire immunological system.

14 Oct 2011

Obese post-menopausal women outperform normal weight counterparts in cognitive tasks

Obesity has been associated with cognitive decline, characterized by a deterioration of mental abilities that involve memory, language, and thought-processing speed.

14 Oct 2011

Study finds vitamin D is critical in human immune response to tuberculosis

"Vitamin D is needed to activate the immune system's response to tuberculosis (TB)," a finding that "could lead to new treatments for the lung disease," researchers from the University of California in Los Angeles (UCLA) said in a study published Wednesday in the journal Science Translational Medicine, Agence France-Presse reports.

14 Oct 2011

Penn researchers demonstrate sound-processing deficits in mice brains with mutated dysbindin gene

Recent studies have identified many genes that may put people with schizophrenia at risk for the disease. But, what links genetic differences to changes in altered brain activity in schizophrenia is not clear. Now, three labs at the Perelman School of Medicine at the University of Pennsylvania have come together using electrophysiological, anatomical, and immunohistochemical approaches - along with a unique high-speed imaging technique - to understand how schizophrenia works at the cellular level.

14 Oct 2011

Researchers identify gut bacteria bile acids linked to effectiveness of statin drugs in lowering cholesterol

Statins can be effective at lowering cholesterol, but they have a perplexing tendency to work for some people and not others. Gut bacteria may be the reason.

14 Oct 2011

Researchers demonstrate that iPS stem cells may be used for gene therapy

This research, published on Oct. 12 on the Nature review website, provides evidence of a major concept could pave the way for the future use of these stem cells to treat humans, through perspective gene therapies.

14 Oct 2011

Scientists characterize and isolate potential stem cells to treat MS, myelin disorders

Scientists have improved upon their own previous world-best efforts to pluck out just the right stem cells to address the brain problem at the core of multiple sclerosis and a large number of rare, fatal children's diseases.

14 Oct 2011

Different molecular mechanisms in suprachiasmatic nucleus linked to jet lag differences

It's no secret that long-distance, west-to-east air travel - Seattle to Paris, for example - can raise havoc with a person's sleep and waking patterns, and that the effects are substantially less pronounced when traveling in the opposite direction.

14 Oct 2011

ESCs express genes linked with early germ cell specification

Ordinarily, embryonic stem cells exist only a day or two as they begin the formation of the embryo itself. Then they are gone. In the laboratory dish, however, they act more like perpetual stem cells - renewing themselves and exhibiting the ability to form cells of almost any type, a status called totipotency.

14 Oct 2011

AiC: Health Research receives U.S. Army grant for neuroimaging studies of human performance

The Arlington Innovation Center: Health Research (AiC: Health Research), of Virginia Tech's National Capital Region, has been awarded a $1.5 million cooperative research and development agreement from the U.S. Army for neuroimaging studies of human performance.

14 Oct 2011

Study: Green vegetables boost immune function

Researchers reporting online in the journal Cell, a Cell Press publication, on October 13th have found another good reason to eat your green vegetables, although it may or may not win any arguments with kids at the dinner table.

14 Oct 2011

Nature publishes Sangamo's gene correction strategy for A1AT deficiency

Sangamo BioSciences, Inc. (Nasdaq: SGMO) announced the publication of a preclinical study demonstrating highly specific, functional correction of the alpha 1-antitrypsin (A1AT) gene defect in patient-derived induced pluripotent stem cells (iPSCs) using zinc finger nucleases.

14 Oct 2011

Survey analyses management of patients suffering from EGFRI toxicities

A recent survey of nurses from seven European countries, published in the peer-reviewed journal ecancermedicalscience, has analysed the management of patients suffering from toxicities due to treatment with epidermal growth factor receptor inhibitors.

14 Oct 2011

Medical Science News

Achievement of pre-clinical milestone triggers $4M payment from GSK to Epizyme

Exercise stimulates two beneficial proteins in women before and during pregnancy

Virtual brain models for epilepsy and schizophrenia

Scientists uncover vast new gene regulatory network linked with cancer

Scientists reveal how resistance to hormone leptin develops

Brain stem cell treatment for multiple sclerosis

NextBio predicts mechanisms underlying drug toxicity and identifies new cancer biomarker

Engineered HBLs could prevent deadly allergic reactions

Obese post-menopausal women outperform normal weight counterparts in cognitive tasks

Study finds vitamin D is critical in human immune response to tuberculosis

Penn researchers demonstrate sound-processing deficits in mice brains with mutated dysbindin gene

Researchers identify gut bacteria bile acids linked to effectiveness of statin drugs in lowering cholesterol

Researchers demonstrate that iPS stem cells may be used for gene therapy

Scientists characterize and isolate potential stem cells to treat MS, myelin disorders

Different molecular mechanisms in suprachiasmatic nucleus linked to jet lag differences

ESCs express genes linked with early germ cell specification

AiC: Health Research receives U.S. Army grant for neuroimaging studies of human performance

Study: Green vegetables boost immune function

Nature publishes Sangamo's gene correction strategy for A1AT deficiency

Survey analyses management of patients suffering from EGFRI toxicities

The evolution of OCT for retinal imaging and disease intervention

Supercharging Next-Gen Antibody Discovery with AI and High-Throughput Experimentation

Prof. Dr. Kristina Kusche-Vihrog

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