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Epigenetic mechanisms maintain tolerance in T cells specific for self antigens

At the most basic level, the immune system must distinguish self from non-self, that is, it must discriminate between the molecular signatures of invading pathogens (non-self antigens) and cellular constituents that usually pose no risk to health (self-antigens).

14 Feb 2012

New light on treatment targets for potentially life-threatening cardiac arrhythmia conditions

That flutter in your heart may have more to do with the movement of sodium ions than the glance of a certain someone across a crowded room.

14 Feb 2012

'Targeted' drugs may be effective against lung and colorectal tumors driven by novel gene abnormalities

Novel gene abnormalities discovered in a subpopulation of lung and colorectal tumors could potentially identify patients with a good chance of responding to highly specific "targeted" drugs already in use for treating other cancers, scientists report.

14 Feb 2012

Radiation treatment transforms breast cancer stem cells into new iBCSCs

Breast cancer stem cells are thought to be the sole source of tumor recurrence and are known to be resistant to radiation therapy and don't respond well to chemotherapy.

14 Feb 2012

Scientists create fungi with additional foreign genes to produce chemicals for drugs

Usually, mould fungi are nothing to cheer about - but now they can be used as "chemical factories". Scientists at the Vienna University of Technology have succeeded in introducing bacterial genes into the fungus Trichoderma, so that the fungus can now produce important chemicals for the pharmaceutical industry. The raw material used by the fungus is abundant - it is chitin, which makes up the shells of crustaceans.

14 Feb 2012

Oxygen deprivation disrupts insulin and glucose regulation in rat pups

Premature infants' immature lungs and frequent dips in blood pressure make them especially vulnerable to a condition called hypoxia in which their tissues don't receive enough oxygen, sometimes leading to permanent brain damage. New animal research suggests that a common practice in caring for these babies might in fact exacerbate this condition, increasing the chances for long-term neurological deficits.

14 Feb 2012

Ensysce announces latest data on delivery platform for therapeutic siRNA

Ensysce Biosciences Inc. announced today the publication of their latest data on their delivery platform for short interfering RNA (siRNA) for therapeutic purposes in the journal Materials.

14 Feb 2012

Promising compound may counteract HIV's ability to hijack CD59 protein

One of the frustrations for scientists working on HIV/AIDS treatments has been the human immunodeficiency virus' ability to evade the body's immune system. Now an Indiana University researcher has discovered a compound that could help put the immune system back in the hunt.

14 Feb 2012

Supply of childhood leukemia drug nearly exhausted

A medicine to treat children's leukemia is in such short supply that hospitals may run out within weeks; meanwhile, families of people with Alzheimer's disease are clamoring to use a skin-cancer drug after a promising study in mice.

14 Feb 2012

Fresh insights into cell division could help scientists develop cancer drugs

Fresh insights into how our cells multiply could help scientists develop drugs to treat cancer. Researchers have gained better understanding of the workings of two key proteins that control cell division. This process must be carried out accurately to keep cells healthy, and when it goes out of control, it can lead to cancer.

14 Feb 2012

New potential therapy for Huntington disease

Medical researchers at the University of Alberta have discovered a promising new therapy for Huntington disease that restores lost motor skills and may delay or stop the progression of the disease based on lab model tests, says the lead researcher.

14 Feb 2012

Radiation induces testicular cancer in male fetuses

Male fetuses of mothers that are exposed to radiation during early pregnancy may have an increased chance of developing testicular cancer, according to a study in mice at The University of Texas MD Anderson Cancer Center.

14 Feb 2012

Two prefrontal cortex areas critical in distinguishing emotions from facial expressions

It's Valentine's Day, he forgot to bring flowers, and somehow that painfully sad look on her face is simply not registering in his mind. Could be it's a problem in his prefrontal cortex? Neuropsychology researchers at the Montreal Neurological Institute and Hospital - The Neuro, McGill University, have found that two areas of the prefrontal cortex (PFC) are critical for either detecting or distinguishing emotions from facial expressions.

14 Feb 2012

Scientists create new mouse model for medulloblastoma

Scientists at Sanford-Burnham Medical Research Institute (Sanford-Burnham) developed a new mouse model for studying a devastating childhood brain cancer called medulloblastoma.

14 Feb 2012

Scientists develop mutant zebrafish to study Maple Syrup Urine Disease

In medical research, finding a reliable and cost-effective animal model can greatly enhance success in identifying disease mechanisms and genetic pathways, potentially cutting years off drug testing regimes and development of new treatment strategies.

14 Feb 2012

Marshall University researcher to understand connections between cancer and obesity

A Marshall University researcher has been awarded a one-year, $60,000 grant from the Pharmaceutical Research and Manufacturers of America (PhRMA) Foundation.

14 Feb 2012

Agilent's microarrays used in landmark study on prenatal samples

Agilent Technologies Inc. today announced its microarrays were used in a landmark research study on prenatal samples. The three-year study was designed to evaluate the accuracy, efficacy and potential advantages of using microarray analysis as compared with conventional karyotyping. Agilent SurePrint CGH microarrays and analysis software were used for the majority sample cohort of 4,400 samples.

14 Feb 2012

People with Lynch syndrome face increased risks of breast and pancreatic cancers

A new prospective study of patients with Lynch syndrome - an inherited disorder of cancer susceptibility caused by mutations in specific DNA repair genes - provides the first strong evidence that people with Lynch syndrome face significantly increased risks of breast and pancreatic cancers.

14 Feb 2012

Compound makes imipenem 16 times more effective against antibiotic-resistant K. pneumoniae

North Carolina State University chemists have created a compound that makes existing antibiotics 16 times more effective against recently discovered antibiotic-resistant "superbugs."

14 Feb 2012

Researchers pinpoint source of Loeys-Dietz syndrome

A USC research team has pinpointed the source of a genetic disorder that causes life-threatening birth defects, which may allow doctors to quickly diagnose and better treat the disease.

14 Feb 2012

Medical Science News

Epigenetic mechanisms maintain tolerance in T cells specific for self antigens

New light on treatment targets for potentially life-threatening cardiac arrhythmia conditions

'Targeted' drugs may be effective against lung and colorectal tumors driven by novel gene abnormalities

Radiation treatment transforms breast cancer stem cells into new iBCSCs

Scientists create fungi with additional foreign genes to produce chemicals for drugs

Oxygen deprivation disrupts insulin and glucose regulation in rat pups

Ensysce announces latest data on delivery platform for therapeutic siRNA

Promising compound may counteract HIV's ability to hijack CD59 protein

Supply of childhood leukemia drug nearly exhausted

Fresh insights into cell division could help scientists develop cancer drugs

New potential therapy for Huntington disease

Radiation induces testicular cancer in male fetuses

Two prefrontal cortex areas critical in distinguishing emotions from facial expressions

Scientists create new mouse model for medulloblastoma

Scientists develop mutant zebrafish to study Maple Syrup Urine Disease

Marshall University researcher to understand connections between cancer and obesity

Agilent's microarrays used in landmark study on prenatal samples

People with Lynch syndrome face increased risks of breast and pancreatic cancers

Compound makes imipenem 16 times more effective against antibiotic-resistant K. pneumoniae

Researchers pinpoint source of Loeys-Dietz syndrome

Redefining control and consistency in anaerobic microbiome workflows

AI in Healthcare: How generative tools are transforming clinical practice

The future of automation: Machine learning–driven hepatocyte and organoid counting

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