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OMT announces new human antibody platform using genetically engineered rats expressing human antibodies

Open Monoclonal Technology, Inc. (OMT) today announced its new human antibody platform using the first genetically engineered rats expressing a human antibody repertoire. The company, which also created the first targeted knockout rats in 2009, is now cross-breeding the knockout animals with the rats expressing human antibodies to finalize its platform.

9 Dec 2010

Anchor Therapeutics announces publication describing pepducin technology as novel approach to target GPCR

Anchor Therapeutics today announced the publication of new research in the Proceedings of the National Academy of Sciences USA. The paper describes the identification and characterization of a pepducin-based allosteric agonist that targets CXCR4, a chemokine G protein-coupled receptor found on hematopoietic stem cells and other bone marrow-derived cells.

9 Dec 2010

Estrogen receptor beta inactivates critical genes, arrests cancer cell growth

Bionovo, today announced the publication of a study demonstrating that ERb causes cancer cell growth arrest by inactivating critical genes and enzymes responsible for cell growth. These results provide evidence that drugs that stimulate the production of or activate ERb are potential new therapies to prevent breast cancer.

9 Dec 2010

Organovo releases data on bioprinted blood vessels

Organovo, Inc., a regenerative medicine company focused on bioprinting technology, today announced the release of data on the first fully bioprinted blood vessels. Data was presented at the Tissue Engineering and Regenerative Medicine International Society (TERMIS) meeting in Orlando, Florida. The blood vessels were created through the use of the NovoGen MMX Bioprinter, Organovo's proprietary platform for the creation of 3D tissue constructs.

9 Dec 2010

Low-cost protein gets big results in people with elevated blood pressure

Beverages supplemented by whey-based protein can significantly reduce elevated blood pressure, reducing the risk of stroke and heart disease, a Washington State University study has found.

8 Dec 2010

ChipDX validates genetic signature for early-stage colon cancer

ChipDX LLC, a New York-based online molecular diagnostics and personalized medicine company, discovered and validated a genetic signature for early-stage colon cancer and is developing an online screening application to enable clinicians to more accurately identify risk of recurrence. In the study, published in the December issue of the British Journal of Cancer, ChipDX demonstrates how the 163-gene signature stratifies colon cancer patients into high- and low-risk groups for recurrence with greater accuracy than current methods.

8 Dec 2010

Low and high vitamin D levels may increase frailty in older women

A recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM) found that lower and higher vitamin D levels were associated with an increased likelihood of frailty in older women. Women with vitamin D levels between 20.0 and 29.9 ng/ml were at the lowest risk of frailty.

8 Dec 2010

UBC's new formulation of Amphotericin B for Visceral Leishmaniasis remains stable in tropical climates

A new formulation of Amphotericin B (AmB) developed by University of British Columbia researchers has been shown to be stable in tropical climates and effective in treating Visceral Leishmaniasis (VL) in mouse models.

8 Dec 2010

Memorial Medical Center selects Mobile Aspects iRISecure Tissue Tracking solution

Mobile Aspects announced today that the Memorial Medical Center located in Springfield IL, has selected Mobile Aspects iRISecure Tissue Tracking solution. The system provides secure storage for implantable human tissue utilized in surgical procedures the technology also automates the activity logging and JCAHO compliance workflows required of clinicians.

8 Dec 2010

North Tees and Hartlepool NHS Foundation Trust pioneer novel technique for breast reconstruction

Surgeons at North Tees and Hartlepool NHS Foundation Trust are pioneering a novel technique for breast reconstruction that has the potential to make a huge difference to the lives of women affected by breast cancer.

8 Dec 2010

Low-dose diazepam with NS-398 combination has twice the neuroprotective effect of NS-398 alone

Status epilepticus, prolonged seizures, can lead to significant neurological deficits and, rarely, even death. The anticonvulsant diazepam, a first line therapy for the condition, is neuroprotective when administered in high doses within two hours from seizure onset. Researchers at the 64th AES Annual Meeting now report that the combination of low-dose diazepam and NS-398, a COX-2 inhibitor, has twice the neuroprotective effect of NS-398 alone.

8 Dec 2010

OPRN collects samples from infants, mothers and fathers to reduce preterm birth complications

Every year, more than 50,000 babies are born premature in the United States. Despite the notable advances in neonatal care, these premature infants often suffer from preterm birth complications - the single largest cause of infant mortality. In order to better understand preterm birth, Nationwide Children's Hospital and The Ohio State University Medical Center (OSUMC) have partnered to form the Ohio Perinatal Research Network (OPRN).

8 Dec 2010

Detection of blood biomarker cTnT associated with structural heart disease

With the use of a highly sensitive test, detection of the blood biomarker cardiac troponin T, a cardiac-specific protein, is associated with structural heart disease and an increased risk of all-cause death, according to a study in the December 8 issue of JAMA.

8 Dec 2010

L. reuteri Protectis reduces frequency of regurgitation by 80% in infants

The study showed that infants supplemented with L. reuteri Protectis reduced the frequency of regurgitation by 80 %. Gastric emptying was significantly accelerated compared to placebo.

8 Dec 2010

Small molecules show promise in protecting brain cells against nerve-degenerative diseases

Investigators at Southern Methodist University and The University of Texas at Dallas have discovered a family of small molecules that shows promise in protecting brain cells against nerve-degenerative diseases such as Parkinson's, Alzheimer's and Huntington's, which afflict millions.

8 Dec 2010

American Society for Microbiology honors UTHealth biologist for significant contributions

Known nationally for her research into single-cell organisms that affect oral health, Millicent "Mimi" Goldschmidt, Ph.D., a professor of microbiology and molecular genetics at The University of Texas Health Science Center at Houston (UTHealth), has been selected to receive the 2011 American Society for Microbiology (ASM) Founders Distinguished Service Award.

8 Dec 2010

New approach points towards effective stem cell therapies for spinal cord injury

Initial experiments suggest a possible new approach to stem cell therapy for spinal cord injuries—using biocompatible "channels" made of chitosan to guide regeneration of new spinal cord tissue, reports the December issue of Neurosurgery, official journal of the Congress of Neurological Surgeons.

8 Dec 2010

Shrink, EV Group enter development agreement for StemDisc stem cell and cell culturing platform

Shrink Nanotechnologies, Inc., an innovative nanotechnology company developing products and licensing opportunities in the solar energy industry, medical diagnostics and sensors and biotechnology research and development tools businesses, announced today that it has entered into a multi-year development and manufacturing agreement with EV Group, a 30 year old Austria-based leader in the nano-imprint lithography process designing and equipment manufacturing.

8 Dec 2010

AHNPs may serve as effective treatment for epilepsy and other disorders with altered neuronal circuitry

Epilepsy research is reaching beyond improving the means for quelling symptoms to the exploration of potential modalities for correcting or reversing alterations in neural function that underlay some forms of the disorder.

8 Dec 2010

Omega-3 fatty acids have antidepressant properties: Study

A new analysis of the effects of omega-3 essential fatty acids offers the hope of enhanced treatment options for tens of millions of people with depression. Two critical omega-3 essential fatty acids available from certain food or nutritional supplements but not manufactured by the body—Eicosapentenoic acid (EPA) and docosahexaenoic (DHA) — play a role in optimal brain functioning and have antidepressant benefits that have not been fully recognized.

8 Dec 2010

Medical Science News

OMT announces new human antibody platform using genetically engineered rats expressing human antibodies

Anchor Therapeutics announces publication describing pepducin technology as novel approach to target GPCR

Estrogen receptor beta inactivates critical genes, arrests cancer cell growth

Organovo releases data on bioprinted blood vessels

Low-cost protein gets big results in people with elevated blood pressure

ChipDX validates genetic signature for early-stage colon cancer

Low and high vitamin D levels may increase frailty in older women

UBC's new formulation of Amphotericin B for Visceral Leishmaniasis remains stable in tropical climates

Memorial Medical Center selects Mobile Aspects iRISecure Tissue Tracking solution

North Tees and Hartlepool NHS Foundation Trust pioneer novel technique for breast reconstruction

Low-dose diazepam with NS-398 combination has twice the neuroprotective effect of NS-398 alone

OPRN collects samples from infants, mothers and fathers to reduce preterm birth complications

Detection of blood biomarker cTnT associated with structural heart disease

L. reuteri Protectis reduces frequency of regurgitation by 80% in infants

Small molecules show promise in protecting brain cells against nerve-degenerative diseases

American Society for Microbiology honors UTHealth biologist for significant contributions

New approach points towards effective stem cell therapies for spinal cord injury

Shrink, EV Group enter development agreement for StemDisc stem cell and cell culturing platform

AHNPs may serve as effective treatment for epilepsy and other disorders with altered neuronal circuitry

Omega-3 fatty acids have antidepressant properties: Study

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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