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KRN cell transfer model provides novel opportunity for rheumatoid arthritis research

Current research provides a novel model for rheumatoid arthritis research. The related report by LaBranche et al, "Characterization of the KRN cell transfer model of rheumatoid arthritis, a chronic yet synchronized version of the K/BxN mouse," appears in the September 2010 issue of The American Journal of Pathology.

8 Sep 2010

Researchers investigate brain network to understand mind disorders

Uncovering the secrets of the brain requires an intense network of collaborative research. Building on a tool that was co-developed in his laboratory and described in a recent issue of Brain, Dr. Yaniv Assaf of Tel Aviv University's Department of Neurobiology is collaborating with an international team of scientists to understand how different parts of the human brain "connect" and to turn this information into a "brain atlas."

8 Sep 2010

Scientists study behaviour of proteins that trigger age-related ailments

Scientists hope to gain insights into a range of age-related ailments, such as dementia, by examining the behaviour of proteins thought to trigger the conditions.Researchers from the University of Edinburgh are to study proteins found in the body to try to find out why these molecules can sometimes clump together as people get older. The clumps interfere with the biological processes that enable the body to function healthily.

8 Sep 2010

Synthetic derivative of Retinoic acid can induce cell death

Retinoic acid (RA), a natural derivative of vitamin A, is the basis of a number of treatments against cancer. Nevertheless, it has certain disadvantages, such as the possibility of the appearance of retinoic acid syndrome, present in 25 % of cases and which can lead to death. The development of 4-HPR, a synthetic derivative of RA, has meant a considerable advance due to its greater efficacy compared to its predecessor.

8 Sep 2010

Study finds multivitamins have no impact on cancer recurrence, survival

Patients with colon cancer who used multivitamins during and after being treated with post-surgical chemotherapy did not reduce the risk of the cancer returning or their dying from it, according to researchers at Dana-Farber Cancer Institute.

8 Sep 2010

Lack of sleep likely to develop diabetes, heart disease: Research

People who sleep less than six hours a night may be three times more likely to develop a condition which leads to diabetes and heart disease, according to researchers at the University of Warwick.

8 Sep 2010

Children's Hospital Boston engages Particle Sciences for drug product development services

Particle Sciences Inc. (PSI), a leading pharmaceutical Contract Research Organization (CRO), has been engaged by Children's Hospital Boston to help advance early stage molecules and drug innovations into new therapeutic products for patient care. Under the established framework between Children's and PSI, Particle Sciences provides drug product development services aimed at progressing the specific drug or drug product candidate to the point where it becomes attractive to potential licensees.

8 Sep 2010

NGP 555 compound effective in preventing amyloid pathology of Alzheimer's disease

In the Sept. 9, 2010 issue of Neuron, Neurogenetic Pharmaceuticals, Inc. (NGP) reports proof of concept studies that show its proprietary compound, NGP 555, is effective in preventing the amyloid pathology of Alzheimer's disease (AD) in a transgenic mouse model.

8 Sep 2010

Quick increase of calcium concentration in cells rapidly trigger Aurora-A kinase enzyme activity

Aurora-A kinase (AurA) is an enzyme that is hyperactive in many cancers and drives tumor cell proliferation. Several AurA inhibitors are currently being tested in clinical trials to see if they slow tumor growth. Now, researchers in the Developmental Therapeutics Program at Fox Chase Cancer Center have identified an activation signal for AurA. They report in the September 7 issue of Nature Communications that a quick increase in the calcium concentration in a cell rapidly triggers AurA kinase activity.

8 Sep 2010

K-State University receives patent for procedures to source stem cells from umbilical cord

Kansas State University has been a issued a patent for a plentiful and noncontroversial source of stem cells from a substance in the umbilical cord.

8 Sep 2010

Decreasing pituitary's sensitivity to insulin could be new target for infertility treatment

Obese women have a well-known risk for infertility, but a new Johns Hopkins Children's Center study has unraveled what investigators there believe is the mechanism that accounts for the risk.

8 Sep 2010

DTC consumers express concern on personal genetic risk test

One half of people using direct to consumer (DTC) personal genetic risk tests express concerns about testing yet more than 80 percent want to know their risk even for non preventable genetic diseases, according to a study in the September Genetics in Medicine, the official peer reviewed journal of The American College of Medical Genetics (ACMG).

8 Sep 2010

Obesity directly accelerates progression of acute lymphoblastic leukemia

The first study to demonstrate that obesity can directly accelerate the progression of acute lymphoblastic leukemia (ALL) has been conducted at The Saban Research Institute of Childrens Hospital Los Angeles and will be published in Cancer Prevention Research, on October 5, 2010. Obesity has been associated with an increased incidence of many cancers, including leukemia, but it has been unknown whether the increase in incidence was a direct effect of obesity or associated with genetic, lifestyle, health, or socio-economic factors.

8 Sep 2010

Interventions targeting social cognition most effective in mitigating loneliness

Changing how a person perceives and thinks about others was the most effective intervention for loneliness, a sweeping analysis of previous research has determined. The findings may help physicians and psychologists develop better treatments for loneliness, a known risk factor for heart disease and other health problems.

8 Sep 2010

Penn receives $12M NIH grant to study pharmacogenetics of nicotine addiction treatment

A variety of smoking cessation treatments are currently available for the more than 18 million adult Americans try to quit smoking each year, but success rates vary widely. Despite the importance of quitting smoking, more personalized approaches to smoking cessation treatment are needed to help smokers pick the right method that will work best for them. A major new personalized medicine clinical trial, led by addiction researchers at the University of Pennsylvania, will study how a smokers' genetic make-up influences their quitting success.

8 Sep 2010

Static stretching leads to decreased running performance

Distance runners who stretch before running may not be able to run as far—and yet spend more energy doing it, according to a study in The Journal of Strength and Conditioning, official research journal of the National Strength and Conditioning Association. The journal is published by Lippincott Williams Wilkins, a part of Wolters Kluwer Health, a leading provider of information and business intelligence for students, professionals, and institutions in medicine, nursing, allied health, and pharmacy.

8 Sep 2010

Study finds increase in bone morphogenetic protein usage for Off-Label procedures

Bone morphogenetic protein (BMP) is increasingly used as an alternative to the patient's own bone for spinal fusion surgery. Yet at least 85 percent of these procedures are operations for which BMP use has not been formally approved by the U.S. Food and Drug Administration (FDA), suggests a study in the September 1 issue of Spine.

8 Sep 2010

Further evidence on adverse effects of smoking on fertility

Two new studies have shed more light on how smoking may damage fertility, and give further weight to advice that mothers and fathers-to-be should stop smoking before attempting to conceive. The research is published online in the reproductive medicine journal Human Reproduction today (Wednesday 8 September).

8 Sep 2010

GE Global Researchers receive award from NIH for human microbiome study

Researchers from GE Global Research have been awarded a $538,000 human microbiome project from the National Institutes of Health (NIH) to develop new technology that would allow for the study of individual cells growing inside and outside the body believed to have a significant impact on human health.

8 Sep 2010

Researchers develop new RNA molecule approach to kill cancer cells

Researchers at the California Institute of Technology (Caltech) have engineered a fundamentally new approach to killing cancer cells. The process developed by Niles Pierce, associate professor of applied and computational mathematics and bioengineering at Caltech, and his colleagues uses small RNA molecules that can be programmed to attack only specific cancer cells then, by changing shape, those molecules cause the cancer cells to self destruct.

8 Sep 2010

Medical Science News

KRN cell transfer model provides novel opportunity for rheumatoid arthritis research

Researchers investigate brain network to understand mind disorders

Scientists study behaviour of proteins that trigger age-related ailments

Synthetic derivative of Retinoic acid can induce cell death

Study finds multivitamins have no impact on cancer recurrence, survival

Lack of sleep likely to develop diabetes, heart disease: Research

Children's Hospital Boston engages Particle Sciences for drug product development services

NGP 555 compound effective in preventing amyloid pathology of Alzheimer's disease

Quick increase of calcium concentration in cells rapidly trigger Aurora-A kinase enzyme activity

K-State University receives patent for procedures to source stem cells from umbilical cord

Decreasing pituitary's sensitivity to insulin could be new target for infertility treatment

DTC consumers express concern on personal genetic risk test

Obesity directly accelerates progression of acute lymphoblastic leukemia

Interventions targeting social cognition most effective in mitigating loneliness

Penn receives $12M NIH grant to study pharmacogenetics of nicotine addiction treatment

Static stretching leads to decreased running performance

Study finds increase in bone morphogenetic protein usage for Off-Label procedures

Further evidence on adverse effects of smoking on fertility

GE Global Researchers receive award from NIH for human microbiome study

Researchers develop new RNA molecule approach to kill cancer cells

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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