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Cardinal Health and UW collaborate to advance use of molecular imaging in clinical investigations and trials

Cardinal Health and the University of Washington (UW) today announced an innovative public-private collaboration designed to advance the use of molecular imaging in clinical investigations and trials.

4 Jun 2010

Ascenta Therapeutics, sanofi-aventis sign global licensing agreement for cancer drug candidates

Ascenta Therapeutics announced today the signing of a global collaboration and licensing agreement with sanofi-aventis covering several early-stage agents being investigated for their potential to restore tumor cell apoptosis (programmed cell death). These orally-active, small-molecule drug candidates inhibit the interaction between HDM2 (Human Double Minute 2) and p53, removing a block to normal p53 tumor suppressor function and potentially enhancing cancer control and treatment.

4 Jun 2010

Infinity announces Phase 2 clinical trial results of IPI-504 for NSCLC

Infinity Pharmaceuticals, Inc. today reported the results from its Phase 2 clinical trial of IPI-504, the company's i.v.-administered Hsp90 chaperone inhibitor, in patients with advanced non-small cell lung cancer (NSCLC). Data reported show that IPI-504 demonstrated clinical activity in patients with NSCLC, in particular among patients with oncogenic anaplastic lymphoma kinase (ALK) gene rearrangements.

4 Jun 2010

Earliest blood flow begins all at once

By capturing movies of both the blood and vasculature of zebrafish embryos, each less than two millimeters long, researchers have been able for the first time to see the very moment that blood begins to flow.

4 Jun 2010

Researchers induce memory of safety in brain of rats

Researchers have found a way to pharmacologically induce a memory of safety in the brain of rats, mimicking the effect of training. The finding suggests possibilities for new treatments for individuals suffering from anxiety disorders.

4 Jun 2010

Diagnosis of antiovarian autoantibodies in infertile women help in approaches for assisted reproduction

Studies on the ovarian antigens and its corresponding specific antibodies have showed the relationship between the incidences of antiovarian autoantibodies and the clinical mani-festation of ovarian dysfunction and infertility in women.

4 Jun 2010

Preclinical data of dual TLR7 and TLR8 agonist in cancer published

Idera Pharmaceuticals, Inc. today announced the publication of data from studies of a dual agonist of Toll-like Receptor 7 and TLR8 in preclinical models of cancer. The Company created this first-in-class RNA-based dual agonist of TLR7 and TLR8 through its chemistry-based approach to identifying novel TLR-targeted drug candidates.

4 Jun 2010

Researchers develop biosensors to monitor concentration of c-di-GMP within single living bacteria cells

Some species of bacteria perform an amazing reproductive feat. When the single-celled organism splits in two, the daughter cell - the swarmer - inherits a propeller to swim freely. The mother cell builds a stalk to cling to surfaces.

4 Jun 2010

Promising results of ABRAXANE for bladder cancer support efficacy of nab-driven chemotherapy

Abraxis BioScience, Inc. announced today that findings from a phase 1 randomized trial demonstrated that the nanoparticle albumin bound (nab®) driven chemotherapy, nab-paclitaxel (ABRAXANE® for Injectable Suspension; paclitaxel albumin protein-bound particles for injectable suspension) is well-tolerated and active in the second-line treatment of high-grade, non-muscle-invasive bladder cancer that has been refractory to standard intra-bladder infusion (intravesical) therapy.

4 Jun 2010

Significant details about Cord Blood America's new Afford-A-Cord program interviewed

Cord Blood America, Inc., said today that its co-founder and CEO, Matthew Schissler, reviewed the reasons for and significant details about its new "Afford-A-Cord" program in an interview with analyst Francis Gaskins.

4 Jun 2010

Life Technologies partners to create Genomic Cancer Care Alliance

Life Technologies Corporation today announced the creation of the Genomic Cancer Care Alliance to help people battling cancer gain access to treatment options found through analysis of their genomic information. Founding partners include Fox Chase Cancer Center, Scripps Genomic Medicine, and the Translational Genomics Research Institute (TGen). The announcement came during the Consumer Genetics Conference being held June 2-4 in Boston.

4 Jun 2010

Researchers generate the first comprehensive genetic parts list of mouse hypothalamus

A Johns Hopkins and Japanese research team has generated the first comprehensive genetic "parts" list of a mouse hypothalamus, an enigmatic region of the brain — roughly cherry-sized, in humans — that controls hunger, thirst, fatigue, body temperature, wake-sleep cycles and links the central nervous system to control of hormone levels.

4 Jun 2010

Novel brain mechanism promises new and effective anesthetics

A brain mechanism involved in both dreaming and waking from sleep may hold the key to new, more effective anesthetics and stimulants, reported neuroscientists at the University of Arkansas for Medical Sciences (UAMS).

4 Jun 2010

Caltech biologists pinpoint molecular changes that help allow global spread of resistance to Tamiflu

Biologists at the California Institute of Technology have pinpointed molecular changes that helped allow the global spread of resistance to the antiviral medication Tamiflu (oseltamivir) among strains of the seasonal H1N1 flu virus.

4 Jun 2010

Private cordblood banking receives support from world-renowned stem cell experts

Four world-renowned stem cell experts have recently given their full support to private cordblood banking. The four scientists supported the "Family Cord Blood Bank" which has just been established in the US by CORD:USE.

4 Jun 2010

Researchers underscore role of jumping genes in maintaining genetic diversity

Using high-throughput sequencing to map the locations of a common type of jumping gene within a person's entire genome, researchers at the University of Pennsylvania School of Medicine found extensive variation in these locations among the individuals they studied, further underscoring the role of these errant genes in maintaining genetic diversity.

4 Jun 2010

Functional profiling using EVA/PCD for prescribing treatment regimens for Stage IV NSCLC improve survival

A team of investigators at Rational Therapeutics, Inc. and the Malcolm Todd Cancer Institute (Long Beach, Calif.) has reported that functional profiling using ex-vivo analysis of programmed cell death (EVA/PCD) can be used to prescribe treatment regimens that double the response rate and survival in patients with Stage IV non-small cell lung cancer (NSCLC). The findings of their phase II clinical trial will be presented on Sunday, June 6th at the 46th Annual Meeting of the American Society of Clinical Oncology (ASCO) in Chicago.

4 Jun 2010

IBM Fellow receives Kavli Prize for seminal work on nanoscience

From the World Science Festival in New York, IBM Fellow Dr. Donald M. Eigler was awarded the most prestigious honor in nanoscience, The Kavli Prize, sharing the honor with Nadrian Seeman, a professor at New York University.

4 Jun 2010

Lovastatin protects animals against plague

An experimental study has revealed that lovastatin, a drug prescribed for the treatment of hypercholesterolemia, protects animals against the deadly effects of plague. This infectious disease is on the upsurge in parts of the world. These results obtained by scientists at the Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (CNRS/Université Aix-Marseille 2) have been published in the journal PLoS ONE.

4 Jun 2010

Oxycyte perfluorocarbon emulsion demonstrates marked neuroprotective effect in rat model of spinal cord injury

Oxygen Biotherapeutics, Inc. today reported on the results of two University of Miami Miller School of Medicine studies involving the Company's third-generation perfluorocarbon, Oxycyte® perfluorocarbon emulsion. Both study reports showed that Oxycyte® has a marked neuroprotective effect in a rat model of spinal cord injury.

4 Jun 2010

Medical Science News

Cardinal Health and UW collaborate to advance use of molecular imaging in clinical investigations and trials

Ascenta Therapeutics, sanofi-aventis sign global licensing agreement for cancer drug candidates

Infinity announces Phase 2 clinical trial results of IPI-504 for NSCLC

Earliest blood flow begins all at once

Researchers induce memory of safety in brain of rats

Diagnosis of antiovarian autoantibodies in infertile women help in approaches for assisted reproduction

Preclinical data of dual TLR7 and TLR8 agonist in cancer published

Researchers develop biosensors to monitor concentration of c-di-GMP within single living bacteria cells

Promising results of ABRAXANE for bladder cancer support efficacy of nab-driven chemotherapy

Significant details about Cord Blood America's new Afford-A-Cord program interviewed

Life Technologies partners to create Genomic Cancer Care Alliance

Researchers generate the first comprehensive genetic parts list of mouse hypothalamus

Novel brain mechanism promises new and effective anesthetics

Caltech biologists pinpoint molecular changes that help allow global spread of resistance to Tamiflu

Private cordblood banking receives support from world-renowned stem cell experts

Researchers underscore role of jumping genes in maintaining genetic diversity

Functional profiling using EVA/PCD for prescribing treatment regimens for Stage IV NSCLC improve survival

IBM Fellow receives Kavli Prize for seminal work on nanoscience

Lovastatin protects animals against plague

Oxycyte perfluorocarbon emulsion demonstrates marked neuroprotective effect in rat model of spinal cord injury

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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