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Findings may yield novel therapeutic strategies for late-stage breast cancer

Researchers from the Boston University School of Medicine (BUSM) have determined how the TGFβ-Smad signaling pathway, which is over activated in late-stage cancers, is responsible for the "epigenetic memory" that maintains unique patterns of regulatory DNA hypermethylation causing silencing of critical genes that facilitate breast cancer progression.

25 Jan 2010

Long-term graft retention is improved through supplementation of fat grafts with ADRCs

Results from Cytori Therapeutics’ preclinical fat grafting study have been published in the February issue of the Annals of Plastic Surgery. This article, entitled “Supplementation of Fat Grafts with Adipose-Derived Regenerative Cells (ADRCs) Improves Long-Term Graft Retention,” examines the science behind cell-enriched autologous fat grafting and its application to cosmetic and reconstructive surgery. The results demonstrate a doubling in graft retention in cell-enriched grafts and provide insight into the mechanisms behind this improvement.

25 Jan 2010

World’s largest repository of correlated genetic genealogical information under creation in Mali

The Utah Arts Council today announced it has selected Faces of Mali, an exhibit of photographs of village life in western Africa, for its 2010 traveling art program. The show, sponsored by Sorenson Molecular Genealogy Foundation (SMGF) and Mali Rising—two Utah-based non-profit organizations—and the Embassy of Mali, opens a window for viewers into a region with a 600-year history as a center for scholarship and trade. The first traveling exhibit is scheduled for Canyon Community Center in Springdale beginning Feb. 4.

25 Jan 2010

Research paves way for future vaccine against gastric adenocarcinoma

Despite a strong response from our immune defence, the body is unable to rid itself of the bacterium Helicobacter pylori. One reason for this is that this bacterium encourages elements of the immune response to remain in tissue, activating the wrong immune cells. Research results that pave the way for a future vaccine are now being published by the Sahlgrenska Academy at the University of Gothenburg, Sweden.

25 Jan 2010

IntegraGen now offers Fluidigm's IFC technology to French researchers

Fluidigm, the inventor of integrated fluidic circuits (IFCs), has joined with IntegraGen SA, one of France’s leading providers of genetic research testing services, to bring IFC technology to French researchers. IntegraGen will offer premium class services to its customers using the Fluidigm BioMark™ System for Genetic Analysis and the Access Array™ sample preparation system for next-generation sequencing. IntegraGen’s lab will also be a demonstration site for researchers investigating Fluidigm’s technology.

25 Jan 2010

Halozyme Therapeutics and BioAtla sign research collaboration agreement

Halozyme Therapeutics, Inc., a biopharmaceutical company developing and commercializing products targeting the extracellular matrix, today announced the signing of an exclusive, worldwide, contract research collaboration agreement with BioAtla, LLC for the development of novel high throughput recombinant protein screening libraries directed against targets in oncology, aesthetic dermatology and inflammation.

25 Jan 2010

Researchers identify new gene signature that predicts cancer recurrence in certain breast tumors

Researchers at Dana-Farber Cancer Institute have discovered a gene activity signature that predicts a high risk of cancer recurrence in certain breast tumors that have been treated with commonly used chemotherapy drugs.

24 Jan 2010

Loss of key proteins may account for molecular abnormalities associated with myotonic dystrophy

Research on the genetic defect that causes myotonic muscular dystrophy has revealed that the mutation disrupts an array of metabolic pathways in muscle cells through its effects on two key proteins.

24 Jan 2010

New technology may allow scientists to monitor real time activity of protein network

A new assay capable of examining hundreds of proteins at once and enabling new experiments that could dramatically change our understanding of cancer and other diseases has been invented by a team of University of Chicago scientists.

24 Jan 2010

New evidence identifies mechanical factors that limit human running speeds

Jamaican sprinter Usain Bolt's record-setting performances have unleashed a wave of interest in the ultimate limits to human running speed. A new study published in the Journal of Applied Physiology offers intriguing insights into the biology and perhaps even the future of human running speed.

23 Jan 2010

3D images of synapsis between neurons through electron cryotomography

A team of researchers from the Max Planck Institute of Biochemistry, in Germany, led by the Spanish physicist Rub-n Fern-ndez-Busnadiego, has managed to obtain 3D images of the vesicles and filaments involved in communication between neurons. The method is based on a novel technique in electron microscopy, which cools cells so quickly that their biological structures can be frozen while fully active.

23 Jan 2010

Researchers set on grand challenge to accomplish targeted drug delivery for heart disease

Virginia Tech researcher Pavlos Vlachos and his students in the College of Engineering have a tall order to tackle: Stem the grim progression of heart disease, which kills hundreds of thousands of people each year in the United States alone.

23 Jan 2010

Study of 16INK4A gene's role in progression of retinoblastoma

Retinoblastoma is a pediatric eye cancer initiated by the loss or mutation of both copies of the retinoblastoma gene. Current evidence suggests that additional genetic alterations are required for retinoblastoma to become fully malignant.

23 Jan 2010

Kalorama report predicts double-digit growth in SNP market

A setback in the scientific basis for SNP (single nucleotide polymorphisms) analysis may turn out to be a blessing in disguise for makers of genotyping equipment, reagents and software, according to Kalorama Information.

23 Jan 2010

Driving impairs language skills, says new study

It is well known that having a conversation (for example on a cell phone) impairs one's driving. A new study indicates the reverse is also true: Driving reduces one's ability to comprehend and use language.

23 Jan 2010

Injectable sealant found to be biocompatible and effective for fetal tissue repair

A sealant inspired by mussels' ability to stick to surfaces under wet conditions has shown promise in the repair of defects in human fetal membranes, according to a recent Northwestern University study.

23 Jan 2010

Study: Warburg effect promotes rapid cell proliferation and tumor growth

A team of scientists led by Professor Adrian Krainer, Ph.D., of Cold Spring Harbor Laboratory has discovered molecular factors in cancer cells that boost the production of an enzyme that helps alter the cells' glucose metabolism. The altered metabolic state, called the Warburg effect, promotes extremely rapid cell proliferation and tumor growth. Adrian Krainer, Ph.D.

23 Jan 2010

Dark chocolates may ease emotional stress

There may well be another important reason for giving your sweetheart sweets for Valentine's Day besides the traditional romantic one: The "chocolate cure" for emotional stress is now getting new support from a clinical trial published online in ACS' Journal of Proteome Research. It found that eating about an ounce and a half of dark chocolate a day for two weeks reduced levels of stress hormones in the bodies of people feeling highly stressed.

23 Jan 2010

NEB's Double Digest Finder and Enzyme Finder tools now available for iPhone and iPod Touch

New England Biolabs' (NEB) popular web tools, Double Digest Finder and Enzyme Finder, are now available for the iPhone™ and iPod® Touch. These tools to help design restriction enzyme experiments are frequently visited on the NEB website, www.neb.com; making them available as free downloads brings their accessibility closer to the bench.

From New England Biolabs 23 Jan 2010

Scientists map origin of MRSA, technology could help understanding of other diseases

"Scientists have found a way to track minutely-differing strains of the 'superbug' MRSA [methicillin-resistant Staphylococcus aureus] as they spread between people and across the globe, a finding that could aid efforts to control the deadly bacteria," Reuters/ABC News reports (Kelland, 1/21).

23 Jan 2010

Medical Science News

Findings may yield novel therapeutic strategies for late-stage breast cancer

Long-term graft retention is improved through supplementation of fat grafts with ADRCs

World’s largest repository of correlated genetic genealogical information under creation in Mali

Research paves way for future vaccine against gastric adenocarcinoma

IntegraGen now offers Fluidigm's IFC technology to French researchers

Halozyme Therapeutics and BioAtla sign research collaboration agreement

Researchers identify new gene signature that predicts cancer recurrence in certain breast tumors

Loss of key proteins may account for molecular abnormalities associated with myotonic dystrophy

New technology may allow scientists to monitor real time activity of protein network

New evidence identifies mechanical factors that limit human running speeds

3D images of synapsis between neurons through electron cryotomography

Researchers set on grand challenge to accomplish targeted drug delivery for heart disease

Study of 16INK4A gene's role in progression of retinoblastoma

Kalorama report predicts double-digit growth in SNP market

Driving impairs language skills, says new study

Injectable sealant found to be biocompatible and effective for fetal tissue repair

Study: Warburg effect promotes rapid cell proliferation and tumor growth

Dark chocolates may ease emotional stress

NEB's Double Digest Finder and Enzyme Finder tools now available for iPhone and iPod Touch

Scientists map origin of MRSA, technology could help understanding of other diseases

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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