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Cluster-coated implant strengthens attachment of joint-replacement implant with bone

Researchers have developed an improved coating technique that could strengthen the connection between titanium joint-replacement implants and a patients' own bone. The stronger connection created by manipulating signals the body's own cells use to encourage growth could allow the implants to last longer.

19 Aug 2010

Mirus Bio launches new TransIT-PRO transfection kit for biotherapeutic protein production

Mirus Bio now offers a new transfection kit ideal for biotherapeutic protein production in large pharma and biotech settings. Mirus Bio's new TransIT-PRO™ Kit will decrease time to produce usable protein by maximizing target protein yields through transient transfection.

19 Aug 2010

Bolder BioTechnology receives $600,000 NIH SBIR grant to study long-acting IL-11 analog in ARS

Bolder BioTechnology, Inc. today announced that it has been awarded a Phase I Small Business Innovation Research (SBIR) grant totaling $600,000 from the National Institute of Allergy and Infectious Diseases (NIAID) of The National Institutes of Health (NIH). The grant will be used to demonstrate the feasibility of using our novel, long-acting IL-11 analog to accelerate platelet recovery and improve survival in a mouse model of Acute Radiation Syndrome (ARS).

18 Aug 2010

Gene-regulating molecule plays key role in development of Th9 cells linked to chronic respiratory tract illness

Scientists at the University Medical Center of Johannes Gutenberg University Mainz, Germany have taken a further step towards improving our understanding of how asthma develops. These new findings show that the gene-regulating molecule "IRF4" plays a key role in the development of T helper 9 lymphocytes (Th9 cells), which can play a major part in the development of this chronic, inflammatory illness of the respiratory tract.

18 Aug 2010

Maternal stress associated with increased risk of schizophrenia in male offspring

For more than a century, clinical investigators have focused on early life as a source of adult psychopathology. Although the hypothesized mechanisms have evolved, a central notion remains: early life is a period of unique sensitivity during which experience confers enduring effects.

18 Aug 2010

Human muscles waste away on long duration space flights

Astronaut muscles waste away on long space flights reducing their capacity for physical work by more than 40%, according to research published online in the Journal of Physiology.

18 Aug 2010

Marriage and social support reduce psychological stress

Being married has often been associated with improving people's health, but a new study suggests that having that long-term bond also alters hormones in a way that reduces stress.

18 Aug 2010

Xcelligence System provides real-time detection of neuronal cell death

Time course analyses of neuronal cell death and its underlying mechanisms require laborious experiments and multiple endpoint assays, often involving labelling with irritating compounds and cell disruption. A recent study used the xCELLigence System of Roche to investigate the response of the neuronal-like cell line HT-22 and cultured primary rat cortical neurons to different cell death stimuli and neuroprotectants.

18 Aug 2010

USPTO grants Neogenix Oncology patent for DNAs encoding novel molecular aspects of NPC-1 antibody

Neogenix Oncology, Inc. announced today that the U.S. Patent and Trademark Office (USPTO) has issued Patent No. 7,763,720, with claims related to DNAs encoding the novel molecular aspects of the Company's NPC-1 antibody.

18 Aug 2010

Specific brain abnormalities linked to motor neuron disease in athletes with head trauma

Professional athletes with repetitive head trauma and possibly others with a history of head injuries many years previously may be prone the development of a motor neuron disease similar to amyotrophic lateral sclerosis (ALS or "Lou Gehrig's disease"), reports a study in the September Journal of Neuropathology & Experimental Neurology, official journal of the American Association of Neuropathologists, Inc.

18 Aug 2010

Midatech Group, MonoSol Rx file patent to enable commercialization of drug delivery technology

Midatech Group Ltd., a global leader for the design, development, synthesis and manufacture of nanomedicines, and MonoSol Rx, the leader in developing and manufacturing pharmaceutical films based on its proprietary PharmFilm drug delivery technology, today announced the filing of a provisional US patent application for "Nanoparticle Film Delivery Systems." The applications submitted to the United States Patent and Trademark Office (USPTO) relate to therapeutic uses of nanoparticle-based proteins and peptides delivered in pharmaceutical films.

18 Aug 2010

Scientists develop rapid diagnostic test for detecting meningococcal bacteria

Researchers at Queen's University Belfast and the Belfast Health and Social Care Trust have developed a groundbreaking test for meningitis which could help save lives.A rapid diagnostic test for meningococcal bacteria that can produce results within an hour has been developed by scientists from Queen's Centre for Infection and Immunity and the Trust. The speed of this new test is a vital factor in the treatment of young children with meningococcal meningitis and septicaemia who become very ill over a short period.

18 Aug 2010

Research shows mutation in Prox1 gene may lead to memory, learning problems

St. Jude Children's Research Hospital investigators showed a gene named Prox1 is a key player in normal development of a brain structure crucial for learning and memory and remains active throughout life, nurturing the cells vital for making new memories.This study focused on a small region of the hippocampus known as the dentate gyrus, a brain structure needed for memory and learning that is home to the subgranular zone where the neural stem cells destined to become granule cells are housed. The dentate gyrus is one of two regions of the adult brain where neural stem cells continue to produce the precursor cells that ultimately differentiate into neurons.

18 Aug 2010

Genome-wide study identifies key genetic variant associated with nonalcoholic fatty liver disease

Researchers at Massachusetts General Hospital found that patients with nonalcoholic fatty liver disease (NAFLD) who carry an allele of the PNPLA3 gene have an increased risk of developing advanced disease, including nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. A second study supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) validates these findings and further concludes that in pediatric patients, the same allele is associated with earlier disease presentation.

18 Aug 2010

Advanced Cell Technology to obtain patent for cellular reprogramming, generation of iPS cells

Advanced Cell Technology, Inc. announced today that it is positioned to obtain significant patents relating to cellular reprogramming and the generation of induced pluripotent stem (iPS) cells. iPS cells are similar to embryonic stem (ES) cells, except they are generated from adult cells such as skin using certain reprogramming factors, without the controversial use of embryos. Although human iPS cells were first produced in 2007, ACT has been working on inducing pluripotency, with positive results, for more than a decade. The Company's efforts go back to the 1990s, providing (through existing patent filings and continuations) some of the earliest priority dates in the field.

18 Aug 2010

Mature stem cell research development hinges on quality of science peer review

Are there too many stem cell research journals? This question has been posed by Drs. Paul Sanberg and Cesar Borlongan of the Department of Neurosurgery and Brain Repair at the University of South Florida. Their article appears in the current issue of Stem Cell Reviews and Reports.Both Sanberg and Borlongan are concerned about the quality of the science being published in the proliferating stem cell journals.

18 Aug 2010

Researcher unveils unique stem cell partnership that can lead to advances in regenerative medicine

A study led by a researcher at Albert Einstein College of Medicine of Yeshiva University has revealed a unique "partnership" between two types of bone marrow stem cells, which could lead to advances in regenerative medicine. The aim of regenerative medicine is to enable the body to repair, replace, restore or regenerate damaged or diseased cells, tissues and organs.

18 Aug 2010

UK scientists receive Royal Society awards for cancer research

Two Cancer Research UK scientists were recently awarded prestigious Royal Society Awards, while a number of Cancer Research UK scientists were elected fellows of the Royal Society and the Academy of Medical Sciences.Dr Tomas Lindahl is the recipient of the Royal Society Copley Medal, the world's oldest prize for scientific achievement, and Professor Stephen West is awarded this year's GlaxoSmithKline Prize and Lecture.

18 Aug 2010

AMT's MAA for LPLD gene therapy product Glybera on schedule

Amsterdam Molecular Therapeutics, a leader in the field of human gene therapy, today announced that the Marketing Authorisation Application (MAA) for Glybera(R) remains on schedule following meetings with the European Medicine Agency (EMA) concerning the Day 120 List of Questions. The company is confident that Glybera(R), a gene therapy product for lipoprotein lipase deficiency (LPLD), remains on track for a regulatory decision by mid-2011.

18 Aug 2010

Review on energy drinks that claim athletic performance enhancement

Popular energy drinks promise better athletic performance and weight loss, but do the claims hold up? Not always, say researchers at Nova Southeastern University in Florida."Energy drinks typically feature caffeine and a combination of other ingredients, including taurine, sucrose, guarana, ginseng, niacin, pyridoxine and cyanocobalamin," says Stephanie Ballard, PharmD., assistant professor of pharmacy practice at Nova Southeastern University's West Palm Beach campus.

18 Aug 2010

Medical Science News

Cluster-coated implant strengthens attachment of joint-replacement implant with bone

Mirus Bio launches new TransIT-PRO transfection kit for biotherapeutic protein production

Bolder BioTechnology receives $600,000 NIH SBIR grant to study long-acting IL-11 analog in ARS

Gene-regulating molecule plays key role in development of Th9 cells linked to chronic respiratory tract illness

Maternal stress associated with increased risk of schizophrenia in male offspring

Human muscles waste away on long duration space flights

Marriage and social support reduce psychological stress

Xcelligence System provides real-time detection of neuronal cell death

USPTO grants Neogenix Oncology patent for DNAs encoding novel molecular aspects of NPC-1 antibody

Specific brain abnormalities linked to motor neuron disease in athletes with head trauma

Midatech Group, MonoSol Rx file patent to enable commercialization of drug delivery technology

Scientists develop rapid diagnostic test for detecting meningococcal bacteria

Research shows mutation in Prox1 gene may lead to memory, learning problems

Genome-wide study identifies key genetic variant associated with nonalcoholic fatty liver disease

Advanced Cell Technology to obtain patent for cellular reprogramming, generation of iPS cells

Mature stem cell research development hinges on quality of science peer review

Researcher unveils unique stem cell partnership that can lead to advances in regenerative medicine

UK scientists receive Royal Society awards for cancer research

AMT's MAA for LPLD gene therapy product Glybera on schedule

Review on energy drinks that claim athletic performance enhancement

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