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Successful reduction in the levels of aggregated Abeta with GSMs

EnVivo Pharmaceuticals today reported the successful reduction in the levels of aggregated Abeta or Beta-Amyloid in an aged transgenic model (Tg2576) of Alzheimer's disease with its lead gamma-secretase modulator (GSM) EVP-0962. The aggregated Abeta, containing predominately oligomeric and larger Abeta fibrillar species, is considered to be the toxic entity in Alzheimer's disease.

9 Dec 2009

Mouse model may help identify unknown mutations that make lung cancer cells resistant to therapy

Lung cancer is the leading cause of cancer mortality worldwide and lung adenocarcinoma is the most common type. Many cases of lung adenocarcinoma are attributed to a mutation in a gene for the epidermal growth factor receptor (EGFR).

9 Dec 2009

TMZ and small molecule combination appears to lower tumor resistance

University of Florida researchers have found a way to use just a fraction of the normal dosage of a highly toxic, debilitating chemotherapy drug to achieve even better results against colon cancer cells.

9 Dec 2009

Social isolation and stress may increase susceptibility to breast cancer, finds US study

Scientists at the University of Chicago found that rats which were prone to developing breast tumours were 3.3 times more likely to develop cancer if they were kept in isolation and suffered related stress.

9 Dec 2009

Transgenomic's SURVEYOR Scan K-RAS mutation detection kit launched

Transgenomic, Inc. announced today the launch of its SURVEYOR Scan K-RAS kit, the first in a family of mutation detection kits the company plans to offer featuring its proprietary SURVEYOR Nuclease and WAVE® HS DHPLC platform. SURVEYOR Scan technology is a novel approach to mutation detection that uses a PCR amplification reaction and hybridization to form heteroduplex DNA molecules in samples with K-RAS mutation.

9 Dec 2009

Spine system: A new technique to treat lower back pain

Using a branch of science that crosses disciplines to study complex problems, a Michigan State University researcher is introducing a new way to understand and treat lower back pain, a condition affecting more than 40 million Americans and costing billions of dollars each year.

9 Dec 2009

Biomarkers can be important in identifying PTSD symptoms, says researchers

Veterans of Operation Enduring Freedom (OEF) and Operation Iraqi Freedom (OIF) frequently experience high rates of PTSD along with symptoms of depression and pain. However, little is known about why these symptoms occur together or the most effective treatments that can be used to alleviate them. One approach that may yield new insights is to search for biomarkers -- indicators of a biological state that can be easily and reliably measured in people with an illness -- to see if their presence or absence can predict symptoms that an individual will experience and identify optimal treatment strategies.

9 Dec 2009

Progenitor-cell therapy can reduce risk of another heart attack

Cells from heart attack survivors' own bone marrow reduced the risk of death or another heart attack when they were infused into the affected artery after successful stent placement, according to research reported in the American Heart Association journal Circulation: Heart Failure.

9 Dec 2009

Multi-institutional study identifies potential treatment target for ovarian cancer

A multi-institutional study has identified a potential personalized treatment target for the most common form of ovarian cancer. In the December 8 issue of Cancer Cell, the research team describes finding that a gene called MAGP2 - not previously associated with any type of cancer - was overexpressed in papillary serous ovarian tumors of patients who died more quickly. They also found evidence suggesting possible mechanisms by which MAGP2 may promote tumor growth.

9 Dec 2009

Xanthohumol compound may aid in preventing prostate cancer

The natural compound xanthohumol blocks the effects of the male hormone testosterone, therefore aiding in the prevention of prostate cancer.

9 Dec 2009

Immune-boosting drug: A new way for improving cancer treatment

Stimulating the body's own immune system to fight cancer offers new treatment opportunities for cancer patients, and scientists have made the first step towards finding existing drugs that could help.

9 Dec 2009

New findings suggest Ginkgo extract can improve cognitive functions

"Ginkgo biloba not only improves declining memory but offers specific benefits for other cognitive functions as well" that's how Dr. Reiner Kaschel, Clinical Neuropsychologist at the University of Osnabrueck, Germany, summarizes the results of a comprehensive new scientific publication.

9 Dec 2009

New breakthrough study shows reconstruction of human mandible bone with dental stem cells

In a statement today, StemSave(TM), Inc., the market leader in the field of stem cell recovery and cryo-preservation lauds research published in the November issue of the European Cells and Materials Journal citing the reconstruction of the human mandible bone with autologous dental pulp stem cells.

9 Dec 2009

Neuroscientists suggest risky therapy for aging brain may be avoidable by focusing on hormone target

Estrogen seems to act like a middleman in its positive effect on the brain, raising the possibility that future drugs may bypass the carcinogenic hormone altogether while reaping its benefits.

8 Dec 2009

New evidence finds link between nutrition, obesity and immune system

Fresh evidence that fatty food is bad for our health has come to light: mice fed a lard-based diet over a long period got worse at fighting bacteria in the blood, reveals a thesis from the Sahlgrenska Academy at the University of Gothenburg.

8 Dec 2009

Combination of gene and cell therapy improves critical limb ischemia associated with aging or diabetes

Blood vessel blockage, a common condition in old age or diabetes, leads to low blood flow and results in low oxygen, which can kill cells and tissues. Such blockages can require amputation resulting in loss of limbs. Now, using mice as their model, researchers at Johns Hopkins have developed therapies that increase blood flow, improve movement and decrease tissue death and the need for amputation.

8 Dec 2009

Scientists identify new potential drug for treating acute myeloid leukaemia

EUREKA project E! 3172 NKSTIM has produced a new potential drug to stimulate cancer patients' own 'natural killer' cells to attack and eliminate cancer cells; currently undergoing clinical testing in patients with leukaemia or myeloma.

8 Dec 2009

MCG receives $1.8M stimulus grant

It's a $1.8 million shot in the arm to the largest grant the Medical College of Georgia has ever received.

8 Dec 2009

RIVA System effective in automatically compounding IV doses in syringes with minimal contamination

A recent study demonstrated the RIVA System (Robotic Intravenous Automation) - a self-contained unit for aseptic compounding from Intelligent Hospital Systems (IH Systems) - is an effective tool in automatically compounding IV doses in syringes and bags with minimal drug contamination.

8 Dec 2009

CombinatoRx presents encouraging results from its A2A and b2AR agonist programs for B-cell malignancies

CombinatoRx, Incorporated today announced that preclinical data from its Adenosine A2A receptor (A2A) and Beta-2 Adrenergic Receptor (b2AR) Agonist oncology programs demonstrated synergistic anti-cancer activity when combined with standard-of-care therapies in multiple myeloma and other B-cell malignancies.

8 Dec 2009

Medical Science News

Successful reduction in the levels of aggregated Abeta with GSMs

Mouse model may help identify unknown mutations that make lung cancer cells resistant to therapy

TMZ and small molecule combination appears to lower tumor resistance

Social isolation and stress may increase susceptibility to breast cancer, finds US study

Transgenomic's SURVEYOR Scan K-RAS mutation detection kit launched

Spine system: A new technique to treat lower back pain

Biomarkers can be important in identifying PTSD symptoms, says researchers

Progenitor-cell therapy can reduce risk of another heart attack

Multi-institutional study identifies potential treatment target for ovarian cancer

Xanthohumol compound may aid in preventing prostate cancer

Immune-boosting drug: A new way for improving cancer treatment

New findings suggest Ginkgo extract can improve cognitive functions

New breakthrough study shows reconstruction of human mandible bone with dental stem cells

Neuroscientists suggest risky therapy for aging brain may be avoidable by focusing on hormone target

New evidence finds link between nutrition, obesity and immune system

Combination of gene and cell therapy improves critical limb ischemia associated with aging or diabetes

Scientists identify new potential drug for treating acute myeloid leukaemia

MCG receives $1.8M stimulus grant

RIVA System effective in automatically compounding IV doses in syringes with minimal contamination

CombinatoRx presents encouraging results from its A2A and b2AR agonist programs for B-cell malignancies

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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