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The American Journal of Pathology: Highlights from February 2010 issue

A group led by Dr. Peter Lloyd Jones at the University of Dundee, Dundee, Scotland; the University of Colorado Denver, Aurora, CO; and the University of Pennsylvania, Philadelphia, PA has demonstrated that tenascin-C affects proto-oncogene function in breast cancer. Their report can be found in the February 2010 issue of The American Journal of Pathology.

22 Jan 2010

hESC "reporter" line to measure endothelial cell production and activity

New York Stem Cell Foundation (NYSCF)-Druckenmiller Fellow, Daylon James, PhD, of Weill Cornell Medial College, is lead author on a study defining conditions for generating a plentiful supply of endothelial (vessel lining) cells that are suitable for therapeutic use. Dr. James and his colleagues created a human embryonic stem cell (hESC) "reporter" line that can be used to measure endothelial cell production and activity.

22 Jan 2010

Research shows frozen human eggs are as effective as fresh eggs to preserve fertility

Fertility specialists responsible for the first pregnancy in the Pacific Northwest resulting from frozen human eggs are hailing new research showing that frozen eggs can be as effective as fresh eggs in helping previously infertile women achieve pregnancy.

22 Jan 2010

New study indicates viruses employ a novel mechanism to spread more quickly than thought possible

New video footage of a virus infecting cells is challenging what researchers have long believed about how viruses spread, suggesting that scientists may be able to create new drugs to tackle some viruses.

22 Jan 2010

Norepinephrine responses to bucindolol influenced by alpha-2C adrenergic receptor genotype

ARCA biopharma, Inc., a biopharmaceutical company developing genetically targeted therapies for heart failure and other cardiovascular disease, today announced that the paper “An alpha-2C-Adrenergic Receptor Polymorphism Alters the Norepinephrine Lowering Effects and Therapeutic Response of the Beta Blocker Bucindolol in Chronic Heart Failure” was published in the January 2010 edition of the peer-reviewed journal Circulation: Heart Failure (http://circheartfailure.ahajournals.org).

22 Jan 2010

Researchers discover genetic variations that predict clinical outcomes in patients with stomach cancer

Researchers at the University of Southern California (USC) have, for the first time, identified specific genetic variations that predict clinical outcomes in patients with gastric (stomach) cancer.

22 Jan 2010

Vitamin D insufficiency associated with higher risk of relapse attacks in patients with MS

Low vitamin D blood levels are associated with a significantly higher risk of relapse attacks in patients with multiple sclerosis (MS) who develop the disease during childhood, according to a study conducted by researchers from the University of California, San Francisco.

22 Jan 2010

Researchers identify new therapeutic approach for stroke treatment

For the first time, research led by Youming Lu, PhD, MD, Professor of Neurology and Neuroscience at LSU Health Sciences Center New Orleans School of Medicine, has identified a novel mechanism that may trigger brain damage during stroke and identified a therapeutic approach to block it.

22 Jan 2010

Pioneering research explores possibility of developing mineral enriched flour

Pioneering research combining plant breeding and high-intensity x-rays is being used by scientists funded by the Biotechnology and Biological Sciences Research Council (BBSRC) to explore the possibility of developing wheat which could be used to make potentially life-saving mineral enriched flour.

22 Jan 2010

AKD Global announces new class of cancer treatments in development

AKD Global announced today the discovery of a new class of cancer treatments in development, providing hope for millions of sufferers. The spectacular results demonstrate a highly potent effect on cancer cells with no toxicity to healthy tissue. AKD is raising funds to continue development.

22 Jan 2010

Findings may provide new insights into diabetes; suggest novel targets for drug intervention

The neuropeptide corticotropin-releasing factor (CRF) makes cameo appearances throughout the body, but its leading role is as the opening act in the stress response, jump-starting the process along the hypothalamus-pituitary-adrenal (HPA) axis. Researchers at the Salk Institute for Biological Studies have found that CRF also plays a part in the pancreas, where it increases insulin secretion and promotes the division of the insulin-producing beta cells.

22 Jan 2010

Understanding mechanism of SIRT6 activity may help treat diabetes and cancer

A study investigating how a cellular enzyme affects blood glucose levels in mice provides clues to pathways that may be involved in processes including the regulation of longevity and the proliferation of tumor cells.

22 Jan 2010

Intrinsic Bioprobes licenses diabetes biomarkers to Ortho-Clinical Diagnostics

Intrinsic Bioprobes today announced the exclusive licensing of two novel biomarkers for diabetes to Ortho-Clinical Diagnostics, Inc. (Raritan, NJ). The biomarkers are modified forms of blood-circulating proteins and have been linked with the presence of pre-diabetes and type 2 diabetes. The financial terms of the licensing agreement were not disclosed.

From Ortho-Clinical Diagnostics, Inc. 22 Jan 2010

Australian scientists discover cells that cause a common type of childhood leukaemia

Scientists at The Royal Melbourne Hospital and the University of Melbourne in Australia have discovered the cells that cause a common type of childhood leukaemia - T cell Acute Lymphoblastic Leukaemia (T-ALL). Targeting of these cells may lead to improved treatments for this disease and help prevent relapse.

22 Jan 2010

Findings may aid in developing therapeutic drugs for stroke and other neurodegenerative diseases

Biomedical scientists from the University of Central Florida and Louisiana State University have identified a way to block a "cell death signal" that they believe triggers brain damage during strokes.

22 Jan 2010

Mice study shows obesity can increase risk of developing liver cancer

Obesity comes with plenty of health risks, but there's one that's perhaps not so well known: an increased risk of developing cancer, and especially certain types of cancer like liver cancer. Now, a group of researchers reporting in the January 22nd issue of the journal Cell, a Cell Press publication, have confirmed in mice that obesity does indeed act as a "bona fide tumor promoter." They also have good evidence to explain how that happens.

22 Jan 2010

Study identifying new form of adult onset muscular dystrophy published

A study published in today's online edition the American Journal of Human Genetics, allowed the first identification of a new form of adult onset muscular dystrophy.

22 Jan 2010

HIV infection causes premature aging of the brain

HIV infection or the treatments used to control it are prematurely aging the brain, researchers at Washington University School of Medicine in St. Louis and the University of California-San Diego have found.

22 Jan 2010

Association between vitamin D and risk of colorectal cancer identified

High blood levels of vitamin D are associated with a lower risk of colon cancer, finds a large European study published on bmj.com today. The risk was cut by as much as 40% in people with the highest levels compared with those in the lowest.

22 Jan 2010

Tel Aviv University psychologist busts myth and offers tips to counter mid-life crisis

Elliot Jacques coined the term "mid-life crisis" 40 years ago, when the average lifespan was 70 and "mid-life" came at age 35. Individuals could expect their quality of life to decline from that point forward, Jacques argued, so some extreme reactions to encroaching mortality were to be expected, such as having extra-marital affairs and buying a Corvette.

22 Jan 2010

Medical Science News

The American Journal of Pathology: Highlights from February 2010 issue

hESC "reporter" line to measure endothelial cell production and activity

Research shows frozen human eggs are as effective as fresh eggs to preserve fertility

New study indicates viruses employ a novel mechanism to spread more quickly than thought possible

Norepinephrine responses to bucindolol influenced by alpha-2C adrenergic receptor genotype

Researchers discover genetic variations that predict clinical outcomes in patients with stomach cancer

Vitamin D insufficiency associated with higher risk of relapse attacks in patients with MS

Researchers identify new therapeutic approach for stroke treatment

Pioneering research explores possibility of developing mineral enriched flour

AKD Global announces new class of cancer treatments in development

Findings may provide new insights into diabetes; suggest novel targets for drug intervention

Understanding mechanism of SIRT6 activity may help treat diabetes and cancer

Intrinsic Bioprobes licenses diabetes biomarkers to Ortho-Clinical Diagnostics

Australian scientists discover cells that cause a common type of childhood leukaemia

Findings may aid in developing therapeutic drugs for stroke and other neurodegenerative diseases

Mice study shows obesity can increase risk of developing liver cancer

Study identifying new form of adult onset muscular dystrophy published

HIV infection causes premature aging of the brain

Association between vitamin D and risk of colorectal cancer identified

Tel Aviv University psychologist busts myth and offers tips to counter mid-life crisis

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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