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Polymer coating improves tumor-targeting nanoparticles

Adding a thin coating of the biocompatible polymer poly(ethylene glycol) (PEG) to the surface of sulfur-modified, or thiolated, nanoparticles designed to fall apart inside tumors, prolongs the time that the resulting nanoparticles remain in tumors.

13 Nov 2006

A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas

In a dramatic demonstration of the power of nanotechnology, a team of investigators has designed a nanoscale, polymeric drug delivery vehicle that when loaded with a widely used anticancer agent cures colon cancer in mice with a single dose.

13 Nov 2006

Nanoparticle probes with surface enhanced Raman spectroscopic tags for cellular cancer targeting

Cancer biologists are always on the lookout for new methods of studying the effects that drug therapy has on malignant cells.

6 Nov 2006

Nanoparticles for two-photon photodynamic therapy in living cells

Photodynamic therapy (PDT) uses a combination of ultraviolet or visible light and a light-sensitive chemical, or photosensitizer, to kill cancer cells using reactive oxygen.

6 Nov 2006

Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems

In an attempt to create a single device that can image and treat tumors simultaneously, researchers at the University of Texas Southwestern Medical Center at Dallas have successfully melded magnetic iron nanoparticles, the anticancer drug doxorubicin, and a polymer tagged with a tumor-targeted molecule into a stable nanoparticle that accumulates inside human tumor cells.

6 Nov 2006

Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery

Though researchers have made substantial progress in developing drug-ferrying nanoparticles that successfully target tumor cells in living animals, including humans, investigators have only now started the detailed work needed to identify formulation parameters that would optimize drug delivery to malignant cells.

6 Nov 2006

Mini artificial liver grown from stem cells

Scientists in Britain have grown the first artificial liver from stem cells, which is the first step in a process which within 10 years could see livers being grown in a laboratory for human transplants.

1 Nov 2006

Detecting rare microRNAs with gold nanoparticles

Over the past three years, numerous studies have shown that short pieces of single-stranded RNA, known as microRNAs, play a central role in the development of at least some cancers.

30 Oct 2006

Multifunctional composite nanoparticles: magnetic, luminescent, and mesoporous

Silica, the mineral of which sand is made, is generally inert in the body and can be modified easily using a variety of well-established chemical reactions.

30 Oct 2006

Self-assembling nanoparticle releases drug into cell cytoplasm

A growing body of research leaves no doubt that nanoparticles can transport drugs into cancer cells, but what is less clear is that the drug payload can exit the tiny endosomes that pull nanoparticles into cells.

30 Oct 2006

Twisted molecule, large and folded like a protein - but completely synthetic

The physiological functions of proteins depend on their folding into a particular spatial structure (tertiary structure): enzymes and their substrates must fit together like the proverbial lock and key.

26 Oct 2006

Researchers identify peptide that spurs cargo transport in nerve cells

For the first time, researchers have identified a peptide that can spur cargo transport in nerve cells, a discovery that could help scientists better understand nerve cell function and test possible therapies for neurodegenerative diseases.

24 Oct 2006

Scientists explain how transport proteins can move in cells without bumping into or sticking to anything

Scientists from the Max Planck Institute for Molecular Cell Biology and Genetics (MPI-CBG) in Dresden, along with a colleague from the University of Florida in the United States, have been carrying out research into how transport proteins can move in cells without bumping into or sticking to anything.

24 Oct 2006

1,500 animal species practice homosexuality

Homosexuality is quite common in the animal kingdom, especially among herding animals. Many animals solve conflicts by practicing same gender sex.

23 Oct 2006

Evolutionary connection between food supply and brain size

In a study of orangutans living on the Indonesian islands of Borneo and Sumatra, scientists from Duke University and the University of Zurich have found what they say is the first demonstration in primates of an evolutionary connection between available food supplies and brain size.

23 Oct 2006

Quantum dots help cancer imaging studies

One of the more difficult diagnostic tasks an oncologist faces is determining if cancer has spread to the lymphatic system, particularly when it is necessary to assess lymphatic drainage from two separate drainage basins.

23 Oct 2006

Multivalent effects of RGD peptides obtained by nanoparticle display

While a growing body of literature has shown that nanoparticle targeting can improve drug delivery and tumor imaging, there have been few systematic studies examining the net positive effect of nanoparticle targeting.

23 Oct 2006

Squalenoyl nanomedicines as potential therapeutics

Nucleoside analogs such as cytarabine and gemcitabine are powerful anticancer agents, but a simple chemical modification that causes them to assemble into stable nanoparticles could make them even more valuable in the treatment of a wide variety of cancers.

23 Oct 2006

Functionalization of individual ultra-short single-walled carbon nanotubes

While most research aimed at developing carbon nanotubes as tumor-targeting drug and imaging agent delivery vehicles has focused on full-length nanotubes, Lon Wilson, Ph.D., and his colleagues at Rice University have been working with ultra-short nanotubes that cells appear to take up more efficiently than their longer counterparts.

23 Oct 2006

Scientists discover why some bacteria are naturally magnetic

Scientists at the Naval Research Laboratory (NRL) and Purdue University have shed light on one of microbiology's most fascinating mysteries--why some bacteria are naturally magnetic.

20 Oct 2006