Medical Science News

RSS

Co-delivery of drugs and DNA from cationic core-shell nanoparticles self-assembled from a biodegradable copolymer

Efforts to treat cancer using genes and other oligonucleotides, such as short interfering RNA (siRNA), that turn off the biochemical processes that trigger malignancies have been hindered by difficulties in delivering nucleic acids to tumors.

16 Oct 2006

A nanoplasmonic molecular ruler for measuring nuclease activity and DNA footprinting

The interactions between proteins and nucleic acids play a critical role in some of life’s most crucial biochemical processes, including gene expression and protein production, and some promising anticancer agents exert their effects by interfering with these interactions.

16 Oct 2006

Membrane targeted chemotherapy with hybrid liposomes for colon tumor cells leading to apoptosis

One of the unusual properties of tumor cells is that their cell membranes are more fluid and less rigid than those of normal cells.

16 Oct 2006

Phase separation of lipid membranes analyzed with high-resolution secondary ion mass spectrometry

Understanding the chemical composition and organization of cell membranes - what components reside next to each other, how many of each there are and how they respond to their environment - may reveal the secret lives of cells in both health and disease.

9 Oct 2006

Photochemistry creates drug-trapping nanoparticles

Many of the most potent anticancer agents are poorly soluble in water, presenting a challenge for medicinal chemists who must develop methods of delivering these drugs in the watery environment of the human body.

9 Oct 2006

Novel attachment method provides boost to biosensor development

A versatile method for attaching precise amounts of biomolecules and even cells to electrically conductive surfaces could lead to a new generation of nanoscale biosensors with broad applicability in cancer diagnostics and basic research.

9 Oct 2006

Built-in blocker - drug and antidote in the same molecule

In cases of serious side effects or overdoses of medications, it can be vital to have a fast-acting antidote on hand.

2 Oct 2006

Simultaneous synthesis and screening in a microfluidics device

In the quest for new methods to synthesize large numbers of drug leads, medicinal chemists are increasingly turning to microfluidics as a means of performing dozens of chemical reactions using minute quantities of chemical reagents.

From Siemens Healthineers 2 Oct 2006

Key parameters for encapsulating drugs in nanoparticles

One of the early, successful uses of nanoparticles has been to develop delivery vehicles capable of ferrying large amounts of water-insoluble drugs to tumors.

2 Oct 2006

Temperature-sensitive nanoparticle boosts drug antitumor activity

Using temperature-sensitive, lipid- and polymer-based nanoparticles with a polymer coating, researchers in Korea have created an anticancer drug delivery vehicle that may provide a significant boost to the therapeutic efficacy of anticancer agents, particularly when used in conjunction with hyperthermia.

2 Oct 2006

Smart nanoscale bioreactors for drug delivery

In a powerful demonstration of how to build a multifunctional, smart nanoscale drug delivery system, researchers at the University of Basel have created a drug-loaded nanocontainer that targets specific cells and releases its payload when receiving a specific physiological signal.

2 Oct 2006

In vitro assessment of transferrin-conjugated liposomes as drug delivery systems for inhalation therapy of lung cancer

Investigators developing an inhalable nanoparticle for treating lung cancer have shown that a surface molecule found on malignant lung cells can serve as an effective target for improving drug delivery.

25 Sep 2006

Multispectral imaging of clinically relevant cellular targets in tonsil and lymphoid tissue using semiconductor quantum dots

When pathologists examine tissue samples in order to diagnose cancer of the lymphatic system, they examine the relative amounts of a group of proteins known as Cluster of Differentiation markers.

25 Sep 2006

Electrochemical fabrication of conducting polymer nanowires in an integrated microfluidic system

There seems to be little doubt among cancer researchers that new detection systems using nanowires and microfluidics hold the promise of providing a quantum leap in the detection of cancer-related molecules and genes.

25 Sep 2006

Carbon nanotube amplification strategies for highly sensitive immunodetection of cancer biomarkers

In an attempt to increase the sensitivity of cancer biomarker detection and to decrease the need for large samples from which to detect those molecules, a multi-institutional research team has shown that a "forest" of single-walled carbon nanotubes can be used to detect lower levels of the prostate specific antigen (PSA) than is possible using the current commercial assay.

25 Sep 2006

Computer model reveals a central "road" in the human stomach

A computer model or "virtual stomach" revealed a central "road" in the human stomach, dubbed the Magenstrasse, that could explain why pharmaceuticals sometimes have a large variability in drug activation times, according to a team creating computer simulations of stomach contractions.

20 Sep 2006

Medical Science News

Co-delivery of drugs and DNA from cationic core-shell nanoparticles self-assembled from a biodegradable copolymer

A nanoplasmonic molecular ruler for measuring nuclease activity and DNA footprinting

Membrane targeted chemotherapy with hybrid liposomes for colon tumor cells leading to apoptosis

Phase separation of lipid membranes analyzed with high-resolution secondary ion mass spectrometry

Photochemistry creates drug-trapping nanoparticles

Novel attachment method provides boost to biosensor development

Built-in blocker - drug and antidote in the same molecule

Simultaneous synthesis and screening in a microfluidics device

Key parameters for encapsulating drugs in nanoparticles

Temperature-sensitive nanoparticle boosts drug antitumor activity

Smart nanoscale bioreactors for drug delivery

In vitro assessment of transferrin-conjugated liposomes as drug delivery systems for inhalation therapy of lung cancer

Multispectral imaging of clinically relevant cellular targets in tonsil and lymphoid tissue using semiconductor quantum dots

Electrochemical fabrication of conducting polymer nanowires in an integrated microfluidic system

Carbon nanotube amplification strategies for highly sensitive immunodetection of cancer biomarkers

Computer model reveals a central "road" in the human stomach

Nanocantilever biosensors detect multiple genes

NIH to map genomic changes of lung, brain, and ovarian cancers

Could quantum dots hold the cure to cancer?

New compounds could make drug-resistant bacteria harmless

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

Latest News