Molecular & Structural Biology

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Reactivating ‘tumor suppressor’ genes could offer new therapeutic approach for cancer

Scientists have developed a method which is able to switch ‘tumor suppressor’ genes back on after they have been silenced by cancer cells.

25 Sep 2019

Improved mapping of genomes from 1,000 Swedish individuals

In so-called whole genome sequencing, surveys are made of the total genome of an individual. It is still relatively rare in healthcare today, but it occurs at an increasing rate, for example in order to make an accurate diagnosis in the case of a rare disease.

25 Sep 2019

Tapeworms need their head for stem cell-driven regeneration

Scientists have identified the stem cells that allow tapeworms to regenerate and found that their location in proximity to the head is essential, according to a new study in eLife.

24 Sep 2019

Ear's tiny outer hair cells regulate sound sensitivity, study shows

The ear’s tiny outer hair cells adjust the sensitivity of neighboring inner hair cells to sound levels rather than acting like an amplifier, suggests a new study published today in eLife.

24 Sep 2019

Mice also fidget like humans while making decisions

Almost everyone fidgets, said Cold Spring Harbor Laboratory Associate Professor Anne Churchland. She referred to a collage of videos she compiled of different people rocking back and forth in their chairs, clicking a pen, shaking their legs.

24 Sep 2019

Study uncovers epigenetic origins for hypersexual disorder

A new study has shown that epigenetic changes lead to overactivity of the hormone oxytocin, and this is a key element in hypersexual disorder.

24 Sep 2019

Discovery provides potential therapeutic target for prostate cancers with PTEN mutation

PTEN, a tumor suppressor gene mutated in approximately 20% of primary prostate cancers, and in as many as 50% of androgen deprivation-resistant prostate cancers, relies on another gene, ARID4B, to function.

24 Sep 2019

New test to establish integrity of biosamples used in medical research

Effective diagnosis and treatment of disease draws on painstaking research, which often relies on biological samples.

23 Sep 2019

Scientists develop method to reactivate tumor suppressor genes 'silenced' by cancer

Scientists at UCL have developed a method to reactivate 'tumor suppressor' genes, which are switched off by cancer cells - a finding which could lead to new targeted biotherapies for cancer.

23 Sep 2019

Researchers uncover fundamental difference in how DNA is held together

Researchers have made a fundamental discovery about the structure of DNA; the structure is held together by water, not hydrogen alone.

23 Sep 2019

CRISPR discovery opens up new possibilities for genetic engineering

Scientists have successfully developed a different kind of CRISPR technology, opening up a world of possibility to future developments in the genetic engineering space

23 Sep 2019

Study provides new insight into how cells maintain their identity

In the body's cells, some proteins are of vital importance as to which genes are active or turned off. Now, researchers from the University of Copenhagen and the Memorial Sloan Kettering Cancer Center have discovered which proteins are necessary in order to maintain the proper genetic regulation.

20 Sep 2019

Researchers discover key similarities between human and archaea chromosomes

A study led by researchers at Indiana University is the first to find similarities between the organization of chromosomes in humans and archaea.

19 Sep 2019

AMP announces recipients of 2019's Award for Excellence in Molecular Diagnostics

The Association for Molecular Pathology (AMP), the premier global, molecular diagnostics professional society, today announced the recipients of this year's Award for Excellence in Molecular Diagnostics, Jeffrey A. Kant Leadership Award and Meritorious Service Award.

19 Sep 2019