Molecular & Structural Biology

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Understanding the molecular pathways that underly nutrient switch in starving cancer cells

Cancer cells often grow in environments that are low in nutrients, and they cope with this challenge by switching their metabolism to using proteins as alternative "food".

9 Sep 2022

Researchers produce high-resolution crystal structure of enzyme critical to SARS-CoV-2 survival

A team of Mount Sinai researchers has produced a high-resolution crystal structure of an enzyme essential to the survival of SARS-CoV-2, the virus that causes COVID-19.

9 Sep 2022

Scientists observe how SARS-CoV-2 protein dismantles critical immunity pathway

Over the past two years, scientists have studied the SARS-CoV-2 virus in great detail, laying the foundation for developing COVID-19 vaccines and antiviral treatments.

9 Sep 2022

Promising anti-cancer agent may also prevent SARS-CoV-2 from replication

Based on findings from a new study by a Johns Hopkins Medicine-led research team, an effective means of fighting SARS-CoV-2, the virus that causes COVID-19, may be possible that circumvents the problem of waning immunity often observed when current vaccines deal with emerging COVID variants.

8 Sep 2022

Insights into molecular structure of protein assembly that plays key role in controlling cristae architecture

Energy supply is a vital component of economic life. And the complex interplay between society and economy is jeopardized whenever core services or key industrial sectors are at risk of failing because of energy supply problems.

7 Sep 2022

Study helps reveal the molecular secrets of macular degeneration

Research led by Sanford Burnham Prebys professor Francesca Marassi, Ph.D., is helping to reveal the molecular secrets of macular degeneration, which causes almost 90% of all age-related vision loss.

7 Sep 2022

Clock gene-dependent glutamate signaling responsible for seasonal regulation of reproduction in bean bugs

Did you know that not only does organism's body have a biological clock that can tell the time of the day, it can also tell the time of the year? Now, researchers from Japan have found that one capable little molecule may be behind the mechanism by which the biological clock keeps track of the seasons.

6 Sep 2022

Researchers develop universally accessible application that can simulate complex molecular interactions

A team led by University of Minnesota Twin Cities biomedical engineers has developed a universally accessible application that can simulate complex molecular interactions, which will allow researchers to design better treatments for diseases like cancer and COVID-19.

6 Sep 2022

Advances in modeling molecular interactions needed to better harness AlphaFold for drug discovery

Over the past few decades, very few new antibiotics have been developed, largely because current methods for screening potential drugs are prohibitively expensive and time-consuming.

6 Sep 2022

DNA levels of monkeypox correlate with virus infectivity

Scientists test clinical samples of MPXV patients to determine the relationship between the MPXV DNA copies and infectious status.

6 Sep 2022

Discovery of bacteria-killing toxin could pave the way for new generation of antibiotics

Researchers at McMaster University have discovered a previously unknown bacteria-killing toxin that could pave the way for a new generation of antibiotics.

6 Sep 2022

New method can accurately, quickly predict which antigens will lead to strong immune response

A cell's secrets can be divulged by its surface, decorated with tens to hundreds of thousands of molecules that help immune cells determine friend from foe.

5 Sep 2022

UTHSC team wins $2.13 million NINDS award to study early neuron development

The National Institute of Neurological Disorders and Stroke has awarded $2.13 million to a University of Tennessee Health Science Center (UTHSC) team studying how neural cells that build a functional brain are generated during embryonic and neonatal life.

2 Sep 2022

Research reveals a starring role for mitochondrial dynamics within adult muscle stem cells

Mitochondria are remarkable shape-shifting organelles that have long been understood as the powerhouses inside our cells.

2 Sep 2022

Transcriptomic approach reveals shared classes of neuron types in reptilian and mammalian brains

These days, dragons are keeping Game of Thrones fans on their toes. But they are also providing important insights into vertebrate brain evolution, as revealed by the work of Max Planck scientists on the brain of the Australian bearded dragon Pogona vitticeps.

2 Sep 2022

'Rippled beta sheet' protein structure created and characterized using x-ray crystallography

An unusual protein structure known as a "rippled beta sheet," first predicted in 1953, has now been created in the laboratory and characterized in detail using x-ray crystallography.

2 Sep 2022

Study opens a window of opportunity to design RAF1 degraders against lung adenocarcinomas

One of the main challenges in oncology is the development of drugs against KRAS oncogenes. These oncogenes -genes that cause cancer when mutated - are responsible for a quarter of all human cancers, including the three tumor types with the highest mortality rates: lung adenocarcinoma, colorectal carcinoma and pancreatic ductal adenocarcinoma.

1 Sep 2022

Rutgers scientists design a synthetic protein that quickly detects molecules of deadly nerve agent

A team that includes Rutgers scientists has designed a synthetic protein that quickly detects molecules of a deadly nerve agent that has been classified by the United Nations as a weapon of mass destruction and could be used in a chemical warfare attack.

1 Sep 2022

Researchers demonstrate improved culture of primate induced pluripotent stem cells

The following study transplanted iPSCs derived from two NHP species, chimpanzee and pigtailed macaque, into blastocysts from another NHP species – the rhesus macaque.

1 Sep 2022

Food for thought: ventral visual pathway has neural populations that respond very selectively to images of food

In this study, a complete set of human cortical specializations was required that actually reflected the functional organization of the cortex.

31 Aug 2022

Molecular & Structural Biology

Understanding the molecular pathways that underly nutrient switch in starving cancer cells

Researchers produce high-resolution crystal structure of enzyme critical to SARS-CoV-2 survival

Scientists observe how SARS-CoV-2 protein dismantles critical immunity pathway

Promising anti-cancer agent may also prevent SARS-CoV-2 from replication

Insights into molecular structure of protein assembly that plays key role in controlling cristae architecture

Study helps reveal the molecular secrets of macular degeneration

Clock gene-dependent glutamate signaling responsible for seasonal regulation of reproduction in bean bugs

Researchers develop universally accessible application that can simulate complex molecular interactions

Advances in modeling molecular interactions needed to better harness AlphaFold for drug discovery

DNA levels of monkeypox correlate with virus infectivity

Discovery of bacteria-killing toxin could pave the way for new generation of antibiotics

New method can accurately, quickly predict which antigens will lead to strong immune response

UTHSC team wins $2.13 million NINDS award to study early neuron development

Research reveals a starring role for mitochondrial dynamics within adult muscle stem cells

Transcriptomic approach reveals shared classes of neuron types in reptilian and mammalian brains

'Rippled beta sheet' protein structure created and characterized using x-ray crystallography

Study opens a window of opportunity to design RAF1 degraders against lung adenocarcinomas

Rutgers scientists design a synthetic protein that quickly detects molecules of deadly nerve agent

Researchers demonstrate improved culture of primate induced pluripotent stem cells

Food for thought: ventral visual pathway has neural populations that respond very selectively to images of food

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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