Molecular & Structural Biology

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Study demonstrates immuno-based strategies to explore the treatment and prevention of COVID-19

Millions have died due to COVID-19 infection, and millions more continue experiencing the chronic condition, Long COVID, which makes discovering practical, accessible, and powerful SARS-CoV-2 preventatives and COVID-19 treatments essential.

11 Nov 2022

Neuromedin U decreases food intake and raises energy expenditure in mice, not in rats

Our sensory urges ranging from anger to hunger are regulated by hormonal or neuronal signals. Often, these impulses appear as behavioral responses, evoked through complex biological reactions.

11 Nov 2022

Study shows the importance of preserving microglia and Sirt1 functional efficiency for longevity

A new research paper was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of Science) Volume 14, Issue 20, entitled, "Age-associated changes in microglia activation and Sirtuin-1- chromatin binding patterns."

11 Nov 2022

Proteomics approach helps identify protein signatures that can improve detection of prediabetes

Scientists have used a proteomics approach to identify a three-protein signature in the blood that can improve detection of isolated impaired glucose tolerance, a form of prediabetes.

10 Nov 2022

MicroRNAs can upregulate proteins in addition to downregulating protein production

microRNAs can play a role in cancer development and are thought to exclusively suppress protein expression in dividing cells, such as tumor cells.

10 Nov 2022

Novel branched ionizable lipid greatly increases the efficiency of mRNA delivery

Messenger RNA (mRNA) are biological molecules that transfer the information coded by genes in the nucleus to the cytoplasm for protein synthesis by ribosomes.

10 Nov 2022

Researchers characterize subtle differences in the brains of primates and humans

While the physical differences between humans and non-human primates are quite distinct, a new study reveals their brains may be remarkably similar. And yet, the smallest changes may make big differences in developmental and psychiatric disorders.

9 Nov 2022

Scientists create an atlas of liver infection caused by Plasmodium parasites

Malaria is a devastating disease caused by the Plasmodium parasite. After an infected mosquitos' bite, the parasites travel to the liver and infect liver cells.

9 Nov 2022

Protein complex may present strong therapeutic target for lethal breast cancer

Researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have shown that a protein complex that governs gene expression (called CoREST) sometimes gets rewired during breast cancer to help estrogen receptor positive (ER+) tumors resist endocrine therapies and become more aggressive.

8 Nov 2022

Study uncovers a previously unknown propofol effect in neurons

Propofol is the most commonly used drug to induce general anesthesia. Despite its frequent clinical application, it is poorly understood how propofol causes anesthesia.

7 Nov 2022

Study sheds light on how Gram-negative bacteria construct outer membrane to resemble body armor

A new study published in the journal Science Advances sheds light on how Gram-negative bacteria like E. coli construct their outer membrane to resemble body armor, which has far-reaching implications for the development of antibiotics.

3 Nov 2022

New insights into the dynamic inner world of the human immune system

As researchers glean new insights into the dynamic inner world of the human immune system, it has become increasingly clear that mitochondria are critical regulators of how our bodies respond to disease.

3 Nov 2022

Vimentin is an important co-receptor for SARS-CoV-2 infection

Vimentin functions as a co-receptor for the entry of SARS-CoV-2 into host cells to facilitate infection.

2 Nov 2022

Study identifies a new therapeutic strategy to tackle endometrial cancer

Inhibition of the ERK5 protein kinase reduces the proliferation and survival of endometrial cancer cells, and potentiates standard chemotherapy.

2 Nov 2022

Molecular drug transporters could improve treatment of cancers and other diseases

A team of Canadian researchers from Université de Montréal has designed and validated a new class of drug transporters made of DNA that are 20,000 times smaller than a human hair and that could improve how cancers and other diseases are treated.

2 Nov 2022

Gut microbiota influences social behavior by stimulating microglial remodeling of brain circuits

To learn to socialize, zebrafish need to trust their gut. Gut microbes encourage specialized cells to prune back extra connections in brain circuits that control social behavior, new UO research in zebrafish shows.

1 Nov 2022

Researchers offer new insights into the neurobiological basis of autism spectrum disorders

Findings from a new study published in Cell Reports, involving a collaborative effort between researchers at the Luikart Laboratory at Dartmouth's Geisel School of Medicine and the Weston Laboratory at the University of Vermont, are providing further insight into the neurobiological basis of autism spectrum disorders (ASD) and pointing to possible treatments.

1 Nov 2022

Molecular & Structural Biology

Study demonstrates immuno-based strategies to explore the treatment and prevention of COVID-19

Neuromedin U decreases food intake and raises energy expenditure in mice, not in rats

Study shows the importance of preserving microglia and Sirt1 functional efficiency for longevity

Proteomics approach helps identify protein signatures that can improve detection of prediabetes

MicroRNAs can upregulate proteins in addition to downregulating protein production

Novel branched ionizable lipid greatly increases the efficiency of mRNA delivery

Researchers characterize subtle differences in the brains of primates and humans

Scientists create an atlas of liver infection caused by Plasmodium parasites

Protein complex may present strong therapeutic target for lethal breast cancer

Study uncovers a previously unknown propofol effect in neurons

Study sheds light on how Gram-negative bacteria construct outer membrane to resemble body armor

New insights into the dynamic inner world of the human immune system

Vimentin is an important co-receptor for SARS-CoV-2 infection

Study identifies a new therapeutic strategy to tackle endometrial cancer

Molecular drug transporters could improve treatment of cancers and other diseases

Gut microbiota influences social behavior by stimulating microglial remodeling of brain circuits

Researchers offer new insights into the neurobiological basis of autism spectrum disorders

New method helps gain fundamental insights into ribosome function

Researchers fabricate cerebral cortical tissues in 3D and functionally integrate them into a brain lesion in mice

High-throughput sequencing reveals structured olfactory neuron projections

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