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Scientists investigate how psychedelic drugs interact with brain cells at the molecular level

Psychedelic drugs such as LSD, psilocybin, and mescaline cause severe and often long-lasting hallucinations, but they show great potential in treating serious psychiatric conditions, such as major depressive disorder.

18 Sep 2020

Study finds wide variation in levels and anti-tumor effectiveness of a common cancer drug

When used to manage infections, the drug itraconazole is generally given at a single, fixed dose to all patients.

17 Sep 2020

PPI use linked to worse outcomes in urothelial cancer patients treated with atezolizumab

Proton pump inhibitor (PPI) use was associated with worse outcomes in patients with urothelial cancer treated with the immunotherapeutic atezolizumab (Tecentriq), compared with patients who did not use PPIs.

17 Sep 2020

IU School of Medicine wins $12.3 million grant for research into opioid addiction treatment

Researchers at Indiana University School of Medicine are testing use of tezampanel, a novel antagonist at glutamate receptors that could treat opioid withdrawal syndrome and other addictions and mental illnesses.

17 Sep 2020

Combined use of three drugs linked with lower lung cancer incidence and mortality

Combined use of aspirin, statins, and metformin is associated with decreased lung cancer incidence and mortality, according to a study published in the Journal of Thoracic Oncology.

17 Sep 2020

Ceftazidime flagged as a potential inhibitor of the SARS-COV-2 virus

After screening more than 3,500 FDA-approved drugs and small molecules, researchers at the Chinese Academy of Sciences found that ceftazidime, an antibiotic approved for use in treating pneumonia, binds to the receptors that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to in human cells.

17 Sep 2020

Study: Pleotropic drugs can have both favorable and unfavorable effects on cell growth, survival

The cover for issue 37 of Oncotarget features Figure 7, "The combination of romidepsin and KU60019 is synergistic in a xenograft model of MCL," by Scotto, et al. which reported that the antiproliferative effect induced by histone deactylase inhibitors is associated with the up-regulated expression of the cyclin-dependent kinase inhibitor p21.

17 Sep 2020

Azithromycin use for treating COVID-19 may increase risk of cardiac events

Debates over whether hydroxychloroquine should be taken to help lessen the duration and impact of COVID-19 have revolved around the drug's reputation for causing cardiac events such as abnormal heart rhythms or beats and cardiac arrest.

16 Sep 2020

Study: Significant proportion of older dental patients inappropriately prescribed opioids

A new study by researchers at the University of Illinois Chicago and the University of Pittsburgh suggests that a significant proportion of older patients receiving opioids at dental visits also use psychotropic medications -- a potentially harmful combination.

16 Sep 2020

UTEP's MARC receives federal grant to fight opioid abuse in West Texas rural counties

The University of Texas at El Paso's Minority AIDS Research Center (MARC) is the subrecipient of a $1 million implementation grant to target substance use disorders and opioid use disorders in five rural counties along the Texas-Mexico border.

16 Sep 2020

Study finds synthetic and desiccated thyroid products to be equally effective in treating hypothyroidism

A study by researchers at Kaiser Permanente in Denver, Colorado evaluated the stability of thyroid stimulating hormone (TSH) in patients using synthetic medication versus those using desiccated thyroid products to treat hypothyroidism.

15 Sep 2020

New clinical trial shows combination of two innovative precision medicines could treat multiple cancers

Launching a dual-pronged attack on tumours using a combination of two innovative precision medicines could treat patients with multiple common cancers, a new clinical trial shows.

15 Sep 2020

Biologic therapy for psoriasis could lead to significant reduction in heart disease

Patients with psoriasis treated with biologic therapy, which are protein-based infusions to suppress inflammation, had a significant reduction in high-risk plaque in heart arteries, over one-year, according to new research published today in Circulation: Cardiovascular Imaging, an American Heart Association journal.

15 Sep 2020

Identifying, preventing and treating drug-induced arrhythmias

Health care professionals should become more familiar with medications that cause irregular heart rhythms called arrhythmias, according to "Drug- Induced Arrhythmias," a new scientific statement from the American Heart Association, published today in the Association's flagship journal Circulation.

15 Sep 2020

Immunologists analyze types of immune response to predict an effective COVID-19 vaccine

Immune reactions caused by vaccination can help protect the organism, or sometimes may aggravate the condition.

15 Sep 2020

Higher doses of Botox may lead to bone loss, shows study

Botox injections to manage jaw and facial pain do not result in clinically significant changes in jaw bone when used short term and in low doses, according to researchers at NYU College of Dentistry.

15 Sep 2020

NIH and FDA examine serious side effect that surfaced in COVID vaccine trial

The Food and Drug Administration is weighing whether to follow British regulators in resuming a coronavirus vaccine trial that was halted when a participant suffered spinal cord damage, even as the National Institutes of Health has launched an investigation of the case.

14 Sep 2020

Drug for liver cirrhosis shows potential to treat dementia and motor neuron disease

A drug used to treat cirrhosis of the liver may be an effective treatment for a form of Dementia and motorneuron disease, scientists have discovered.

14 Sep 2020

Comprehensive analysis of antibody responses in COVID-19 patients can help develop effective vaccine

A comprehensive analysis of antibody responses in coronavirus disease 2019 (COVID-19) patients could inform the development of an effective vaccine, according to a study published September 10 in the open-access journal PLOS Pathogens by Chao Wu and Rui Huang of Nanjing University Medical School, and colleagues.

11 Sep 2020

Effective, simple, safe self-amplifying RNA vaccines

A recent review paper in the journal Current Opinion in Virology in September 2020 shows how a new generation of RNA vaccines called self-amplifying RNA vaccines are more potent than conventional mRNA vaccines and could hold the key to the global production of cost-effective potent COVID-19 vaccines.

11 Sep 2020

Pharmaceutical News

Scientists investigate how psychedelic drugs interact with brain cells at the molecular level

Study finds wide variation in levels and anti-tumor effectiveness of a common cancer drug

PPI use linked to worse outcomes in urothelial cancer patients treated with atezolizumab

IU School of Medicine wins $12.3 million grant for research into opioid addiction treatment

Combined use of three drugs linked with lower lung cancer incidence and mortality

Ceftazidime flagged as a potential inhibitor of the SARS-COV-2 virus

Study: Pleotropic drugs can have both favorable and unfavorable effects on cell growth, survival

Azithromycin use for treating COVID-19 may increase risk of cardiac events

Study: Significant proportion of older dental patients inappropriately prescribed opioids

UTEP's MARC receives federal grant to fight opioid abuse in West Texas rural counties

Study finds synthetic and desiccated thyroid products to be equally effective in treating hypothyroidism

New clinical trial shows combination of two innovative precision medicines could treat multiple cancers

Biologic therapy for psoriasis could lead to significant reduction in heart disease

Identifying, preventing and treating drug-induced arrhythmias

Immunologists analyze types of immune response to predict an effective COVID-19 vaccine

Higher doses of Botox may lead to bone loss, shows study

NIH and FDA examine serious side effect that surfaced in COVID vaccine trial

Drug for liver cirrhosis shows potential to treat dementia and motor neuron disease

Comprehensive analysis of antibody responses in COVID-19 patients can help develop effective vaccine

Effective, simple, safe self-amplifying RNA vaccines

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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