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FDA grants acceptance to application for selumetinib as treatment for neurofibromatosis

AstraZeneca and MSD (Merck) announced today that the U.S. Food and Drug Administration (FDA) has granted acceptance to file status of its application for the MEK inhibitor selumetinib, for use in patients with plexiform neurofibromas, a common manifestation in the disease neurofibromatosis type one (NF1).

14 Nov 2019

Regular co-use of pain and sleep medications may increase risk of frailty in older adults

Researchers from the Oregon Research Institute and Florida Atlantic University are the first to demonstrate statistically significant links between self-reported regular use of prescription drugs for pain and/or sleep, and longitudinal risk of frailty in adults ages 65 and older.

13 Nov 2019

New study highlights opportunities to optimize use of PrEP to prevent HIV among sex workers

Preventing HIV in sex workers is a powerful tool in lowering the worldwide burden of the disease, and a new study could help ensure that high-risk women take advantage of medical safeguards.

13 Nov 2019

$Receiving multiple fracture-associated drugs may increase hip fracture risk$

Receiving multiple fracture-associated drugs may increase hip fracture risk

There is a strong association between the number of fracture-associated drugs (FADs) older patients receive and their risk of sustaining a broken bone, according to a new Dartmouth study published in JAMA Network Open.

13 Nov 2019

Researchers develop novel mathematical framework for mapping out drug interaction

Combining two or more drugs can be an effective treatment of diverse diseases, such as cancer. Yet, at the same time, the wrong drug combination can cause major side effects. Currently there is no systematic understanding of how different drugs influence each other. Thus, elucidating how two given drugs interact, and whether they have a beneficial effect, would mean a major step towards drug development to treat diseases more effectively in the future.

13 Nov 2019

Novartis announces strategy to broaden patient reach and availability of medicines in sub-Saharan Africa

Novartis announced today a new strategy to broaden patient reach and availability of its portfolio of medicines in sub-Saharan Africa, which is home to the largest underserved patient population in the world.

13 Nov 2019

Russian scientists explain how an additional component can triple vaccine efficiency

A team of Russian scientists carried out a study on the cell immunity level and found out how an adjuvant called azoximer bromide increases the immunogenicity of the anti-flu vaccine.

12 Nov 2019

Drug discount cards could lead to higher health care spending

New research published this week in the Canadian Medical Association Journal (CMAJ) reveals that brand-name drug discount cards are leading to higher health care spending in Canada--increased costs that are ultimately passed on to patients.

12 Nov 2019

New approach may help kill Mycobacterium tuberculosis

Current treatment regimens for Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, are long, complex, and hard for people to sustain. Moreover, the bacteria often develop drug resistance, and many people harbor multi-drug-resistant strains. In 2018 alone, nearly 1.5 million people died from tuberculosis worldwide.

12 Nov 2019

Drug regimen for lymphoma and RA more likely to put patients with pemphigus into remission

Pemphigus, an autoimmune disease mediated by B cells and which causes painful blisters and sores on the skin and mucous membranes, is a rare chronic autoimmune condition that can be fatal if not treated.

11 Nov 2019

Researchers develop new, promising class of active ingredients against resistant bacteria

Researchers at the Martin Luther University Halle-Wittenberg have developed a new, promising class of active ingredients against resistant bacteria.

11 Nov 2019

Voters say Congress needs to curb drug prices, but are lawmakers listening?

House Democrats are poised to pass sweeping legislation to lower drug prices using strategies President Donald Trump has endorsed. A Trump aide urged the Republican-controlled Senate to vote on a different package curbing drug prices that was drafted by a senior Republican.

11 Nov 2019

Clinical benefit of anticoagulants for atrial fibrillation decreases with age, shows study

The net clinical benefit of anticoagulants for atrial fibrillation (AF) -- one of the most important causes of irregular heartbeats and a leading cause of stroke -- decreases with age, as the risk of death from other factors diminishes their benefit in older patients, according to a study led by researchers at UC San Francisco.

11 Nov 2019

Opioids do not improve quality of life or depression in OA patients

New research presented at the 2019 ACR/ARP Annual Meeting suggests that opioids contribute no measurable benefit to quality of life or depression for patients with osteoarthritis (OA).

11 Nov 2019

Methotrexate appears to facilitate bone remodeling in patients with osteoarthritis

According to new research findings presented at the 2019 ACR/ARP Annual Meeting, methotrexate did not demonstrate superior efficacy over placebo for pain relief and function evolution at three and 12 months in patients with erosive hand osteoarthritis.

11 Nov 2019

Tocilizumab more effective than rituximab in achieving low disease activity in RA patients

New research discovered that tocilizumab is more effective than rituximab in achieving low disease activity in patients with rheumatoid arthritis whose synovial tissue show a low level of B cell infiltration and did not respond to conventional synthetic disease-modifying anti-rheumatic drugs (conventional synthetic DMARDs) or tumor necrosis factor inhibitors first.

11 Nov 2019

Study provides first data on infectious risk in children exposed to non-TNFi biologics and tofacitinib

A new study found that very few serious infections were seen in children born to mothers with chronic inflammatory diseases who used non-TNFi biologics or tofacitinib during pregnancy compared to children not exposed to these drugs and children exposed to TNFi biologics in utero.

10 Nov 2019

Biologics can be used effectively for both elderly-onset and young-onset RA patients

According to new research findings presented this week at the 2019 ACR/ARP Annual Meeting, both patients with rheumatoid arthritis whose disease onset occurred at an older age and those whose disease onset occurred earlier in life have similar improvements in clinical disease at 48 weeks after starting biologic disease-modifying antirheumatic drugs, as well as similar drug maintenance and adverse events discontinuation rates.

10 Nov 2019

Dengue vaccine from Takeda shows promise

Officials have confirmed the initial success with trials of Dengue vaccine. Dengue, a viral disease borne by mosquitoes is considered to be one of the top ten health threats says the world Health Organization (WHO). Since the beginning of the outbreaks and the hundreds of deaths due to this infection, researchers have been on the lookout for vaccines to prevent this infection.

10 Nov 2019

Common muscle relaxant linked to severe confusion in patients with kidney dysfunction

One in 25 patients with very low kidney function were admitted to hospital with severe confusion and other cognitive-related symptoms a few days after being prescribed a common muscle relaxant.

10 Nov 2019

Pharmaceutical News

FDA grants acceptance to application for selumetinib as treatment for neurofibromatosis

Regular co-use of pain and sleep medications may increase risk of frailty in older adults

New study highlights opportunities to optimize use of PrEP to prevent HIV among sex workers

Receiving multiple fracture-associated drugs may increase hip fracture risk

Researchers develop novel mathematical framework for mapping out drug interaction

Novartis announces strategy to broaden patient reach and availability of medicines in sub-Saharan Africa

Russian scientists explain how an additional component can triple vaccine efficiency

Drug discount cards could lead to higher health care spending

New approach may help kill Mycobacterium tuberculosis

Drug regimen for lymphoma and RA more likely to put patients with pemphigus into remission

Researchers develop new, promising class of active ingredients against resistant bacteria

Voters say Congress needs to curb drug prices, but are lawmakers listening?

Clinical benefit of anticoagulants for atrial fibrillation decreases with age, shows study

Opioids do not improve quality of life or depression in OA patients

Methotrexate appears to facilitate bone remodeling in patients with osteoarthritis

Tocilizumab more effective than rituximab in achieving low disease activity in RA patients

Study provides first data on infectious risk in children exposed to non-TNFi biologics and tofacitinib

Biologics can be used effectively for both elderly-onset and young-onset RA patients

Dengue vaccine from Takeda shows promise

Common muscle relaxant linked to severe confusion in patients with kidney dysfunction

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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