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Optibrium strengthens global AI drug discovery software operations with three key appointments

Optibrium, a leading developer of software and artificial intelligence (AI) solutions for drug discovery, today announced three key appointments.

From Optibrium Ltd. 3 Oct 2022

Broadly neutralizing antibodies are the blueprint for variant-proof, pansarbecovirus vaccines

A recent Nature Reviews Immunology study has summarized the efficacy of neutralizing antibodies that target four main regions of the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), namely, the receptor-binding domain (RBD) in the S1 subunit, the fusion peptide region in the S2 subunit, the stem helix region, and the N-terminal domain.

2 Oct 2022

Burt's Bees research shows the benefits of nature-based regimens to protect and restore skin health

Burt's Bees, the #1 dermatologist recommended natural skin care brand and a pioneer in this area, announced its latest research findings on the benefits of nature-based regimens to protect and restore skin health across various skin conditions, types, and tones.

30 Sep 2022

A novel method to identify spike stabilizing mutations for COVID-19 vaccine development

Researchers discuss a robust method to identify mutations that improve the expression and stabilize the conformation of the SARS-CoV-2 spike protein.

29 Sep 2022

First data on Pfizer-BioNTech's Omicron BA.4/5 combination vaccine

In a recent study posted to the bioRxiv* preprint server, researchers from Germany and the United States analyzed the association between exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.4/BA.5 spike glycoprotein and pan-Omicron neutralization.

27 Sep 2022

Review says dose of approved COVID-19 vaccines based on weak evidence

A recent study posted to the medRxiv* preprint server reviewed early-phase dose-finding trials to examine the study design, safety, and early antibody response data on approved coronavirus disease 2019 (COVID-19) vaccines and gain insights on design improvements for future candidate COVID-19 vaccine clinical trials.

26 Sep 2022

Study looks at boosting with variant-derived COVID vaccine

In a recent study posted to bioRxiv*, researchers at Washington University School of Medicine, St. Louis, demonstrated that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine booster elicits robust germinal center (GC) B cell responses.

26 Sep 2022

Designing a new treatment to treat migraine effectively

In this interview, we speak to Mudra Kapoor, Vice President of Global Medical Affairs for Neuroscience at AbbVie, about atogepant, their new treatment option for migraine.

From AbbVie 26 Sep 2022

Study of 9 million Swedes shows rapidly declining effectiveness of COVID vaccines against Omicron

The findings of a new Swedish study posted to the Preprints with The Lancet* server found that two COVID-19 vaccine doses provided effective long-term protection against infection before Omicron, but less protection against Omicron infection (dropping to 43% by week four and no protection by week 14).

25 Sep 2022

Trial tests efficacy and safety of NVX-CoV2373 COVID-19 vaccine among adolescents

In a recent study posted to the medRxiv* preprint server, researchers in the United States described the safety, efficacy, and immunogenicity of the NVX-CoV2373 vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), tested in PREVENT-19 — a phase 3, randomized, placebo-controlled, observer-blinded trial among 12- to 17-year-old adolescents in the United States (U.S).

25 Sep 2022

New engineered peptides could prevent the superbug crisis

A recent study reports the development of a synthetic antibacterial peptide PLG0206.

22 Sep 2022

All SARS-CoV-2 variants blocked by a simple peptide with nanomolar neutralizing efficacy

In a recent study published in the journal PNAS, researchers from Finland and the United States reported a novel heptad repeat 2 (HR2) peptide that inhibited severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) without any chemical modifications.

21 Sep 2022

Healthy people with high cholesterol don't stand to benefit from statins, research says

About 40 million adults in the United States regularly take statins to lower their cholesterol levels and reduce their risk of heart disease and stroke, according to American Heart Association data from 2020.

20 Sep 2022

Molecular engineered low-cost highly effective RBD-based COVID vaccine

In a recent study posted to the bioRxiv* preprint server, an international team of researchers developed a second-generation severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor binding domain (RBD) antigen (RBD-J6) by molecular engineering with two additional amino acid (aa) substitutions (S383D and L518D mutations) in a hydrophobic cryptic RBD core epitope to enhance stability and expression against SARS-CoV-2 variants of concern (VOCs).

19 Sep 2022

Reducing aspirin use in patients treated with common blood thinner prevents bleeding complications

If you're already taking one blood thinner, mounting research suggests you might not need to take a second one.

19 Sep 2022

Doctors rush to use Supreme Court ruling to escape opioid charges

Dr. Nelson Onaro conceded last summer that he'd written illegal prescriptions, although he said he was thinking only of his patients. From a tiny, brick clinic in Oklahoma, he doled out hundreds of opioid pills and dozens of fentanyl patches with no legitimate medical purpose.

19 Sep 2022

Is aspirin linked to higher rates of survival for cancer patients?

Researchers discussed the existing evidence on the use of acetylsalicylic acid (aspirin) in cancer treatment.

19 Sep 2022

Vaccines used to prevent monkeypox

A new review published in The Lancet Infectious Diseases aimed to describe the efficacy of vaccinia virus-based smallpox vaccines against the current monkeypox outbreak.

18 Sep 2022

Needle-free jet injection of novel COVID-19 DNA vaccine shows promise in animal model

In a recent study posted to the bioRxiv* server, researchers at the United States Army Medical Research Institute of Infectious Diseases evaluated the immunogenicity of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) deoxyribonucleic acid (DNA) vaccine, nCOV-S(JET), in rhesus macaques

18 Sep 2022

An improved COVID-19 vaccine shows promise against Omicron in experimental models

In a recent study published in the journal Science Translational Medicine, researchers in the United States designed a bivalent coronavirus disease 2019 (COVID-19) vaccine on the messenger ribonucleic acid (mRNA) platform.

18 Sep 2022

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Pharmaceutical News

Optibrium strengthens global AI drug discovery software operations with three key appointments

Broadly neutralizing antibodies are the blueprint for variant-proof, pansarbecovirus vaccines

Burt's Bees research shows the benefits of nature-based regimens to protect and restore skin health

A novel method to identify spike stabilizing mutations for COVID-19 vaccine development

First data on Pfizer-BioNTech's Omicron BA.4/5 combination vaccine

Review says dose of approved COVID-19 vaccines based on weak evidence

Study looks at boosting with variant-derived COVID vaccine

Designing a new treatment to treat migraine effectively

Study of 9 million Swedes shows rapidly declining effectiveness of COVID vaccines against Omicron

Trial tests efficacy and safety of NVX-CoV2373 COVID-19 vaccine among adolescents

New engineered peptides could prevent the superbug crisis

All SARS-CoV-2 variants blocked by a simple peptide with nanomolar neutralizing efficacy

Healthy people with high cholesterol don't stand to benefit from statins, research says

Molecular engineered low-cost highly effective RBD-based COVID vaccine

Reducing aspirin use in patients treated with common blood thinner prevents bleeding complications

Doctors rush to use Supreme Court ruling to escape opioid charges

Is aspirin linked to higher rates of survival for cancer patients?

Vaccines used to prevent monkeypox

Needle-free jet injection of novel COVID-19 DNA vaccine shows promise in animal model

An improved COVID-19 vaccine shows promise against Omicron in experimental models

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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