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N-glycosylation blockers reduce SARS-CoV-2 infection

A new Virology study shows that the N-glycosylation pattern of SARS-CoV-2 is crucial to normal spike activity.

20 Feb 2022

Researchers develop novel anti-SARS-CoV-2 Omicron vaccine candidate

Researchers have developed a new vaccine candidate that is specifically targeted against the SARS-CoV-2 Omicron variant.

20 Feb 2022

Researchers use an integrated approach to reveal constituents in a multi-herb Chinese medicine

Rooted in ancient knowledge and principles, traditional Chinese medicine (TCM) has been used to treat many diseases, sparking the interest of pharmaceutical researchers. TCM formulas are quite complex, requiring multiple herbs for their formulation.

18 Feb 2022

Prescribing of ineffective COVID drugs could have been influenced by political affiliation

Two treatments that have been shown to be ineffective against COVID-19—hydroxychloroquine and ivermectin—were more heavily prescribed in the latter part of 2020 in U.S. counties with a higher Republican vote share in the 2020 presidential election, according to a new research letter co-authored by researchers from Harvard T.H. Chan School of Public Health.

18 Feb 2022

Ensitrelvir, a novel SARS-CoV-2 antiviral

S-217622 reduces the viral load and help alleviate the severity of SARS-CoV-2 in infected hamsters.

17 Feb 2022

Cessation of antibiotic prophylaxis in dentistry led to no increase in infective endocarditis

Sweden is one of the few countries that have removed the dental health recommendation to give prophylactic antibiotics to people at a higher risk of infection of the heart valves, so-called infective endocarditis.

17 Feb 2022

Study looks at COVID-19 vaccine hesitancy in France and Italy

A recent study posted to Research Square* preprint server, and under consideration at the journal Scientific Reports, aimed to learn more about how and to what extent vaccine hesitancy can alter over time at the individual level by considering parameters such as dynamic preferences, news reporting, and gender influence.

16 Feb 2022

Single dose of BNT162b2 vaccine after COVID provides 82% reduction in reinfection risk

Researchers compare the incidence rate of reinfection in convalescent and unvaccinated people to that in recovered and single-dose vaccinated people.

16 Feb 2022

Omicron breakthrough boosts neutralization titers a little more than a 3rd COVID vaccine dose

Researchers compare the neutralizing antibody titers in individuals who received two or three mRNA vaccine doses and experienced breakthrough infections.

16 Feb 2022

Study analyzes trends in overdose deaths from use of non-benzodiazepines and gabapentinoids

With an alarming rise in the number of prescriptions filled for non-benzo sleeping/z-drugs and anti-epilepsy gabapentinoids over the last two decades, researchers at Columbia University Mailman School of Public Health aimed to fill in the gap in knowledge in the proportion of overdose deaths involving those medications and learn more about their co-usage with other substances across U.S. demographics categories.

16 Feb 2022

Study shows the true prevalence of statin intolerance worldwide is between 6 to 10%

As many as one in two patients stop taking statins, reduce the dose or take them irregularly because they believe the cholesterol-lowering drugs cause muscle pain and other side-effects.

16 Feb 2022

Inside the tactical tug of war over the controversial Alzheimer’s drug

The drug industry, patient advocates, and congressional Republicans have all attacked federal officials' decision to decline routine Medicare coverage for a controversial Alzheimer's drug.

16 Feb 2022

Two doses of psilocybin may ease depression symptoms for up to 12 months

Previous studies by Johns Hopkins Medicine researchers showed that psychedelic treatment with psilocybin relieved major depressive disorder symptoms in adults for up to a month.

15 Feb 2022

The in vitro selection of a remdesivir-resistant SARS-CoV-2 mutation

Researchers select and study an RDV-resistant virus by serial passaging of wild type SARS-CoV-2 in the presence of increasing concentrations of RDV.

15 Feb 2022

Real-world data on efficacy and safety of COVID vaccines in Canada

In a recent study posted to the medRxiv* preprint server, researchers evaluated the efficacy and safety of the coronavirus disease 2019 (COVID-19) vaccines in young and elderly cohorts from Canada.

14 Feb 2022

Study finds Pfizer-BioNTech COVID vaccine doesn't increase pregnancy risk

A new JAMA Network study describes the effects of maternal COVID-19 vaccination on pregnancy outcomes and infant health.

14 Feb 2022

Researchers identify a powerful combination of antivirals to treat COVID-19

Researchers at the University of Maryland School of Medicine and University of Pennsylvania Perelman School of Medicine have identified a powerful combination of antivirals to treat COVID-19.

14 Feb 2022

mRNA-1273 and mRNA-1273.529 Omicron-specific boosters highly effective in mouse model

In a study posted to the bioRxiv* preprint server, a team of researchers from the United States evaluated the protective effect of the preclinical version of the current Moderna Omicron-targeted mRNA-1273.529 vaccine against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.529 Omicron infection in mice.

14 Feb 2022

Assessing potential allergic reactions in COVID-19 vaccinated patients

Researchers analyze suspected reactions in patients vaccinated with the first and/or second dose of SARS-CoV-2 vaccines.

13 Feb 2022

Challenges in safely deprescribing common anticholinergic drugs

Medications with anticholinergic properties have been consistently associated with a wide range of adverse outcomes for older adults including cognitive impairment, yet these drugs continue to be commonly prescribed for depression, urinary incontinence, irritable bowel syndrome and Parkinson's disease.

11 Feb 2022

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Pharmaceutical News

N-glycosylation blockers reduce SARS-CoV-2 infection

Researchers develop novel anti-SARS-CoV-2 Omicron vaccine candidate

Researchers use an integrated approach to reveal constituents in a multi-herb Chinese medicine

Prescribing of ineffective COVID drugs could have been influenced by political affiliation

Ensitrelvir, a novel SARS-CoV-2 antiviral

Cessation of antibiotic prophylaxis in dentistry led to no increase in infective endocarditis

Study looks at COVID-19 vaccine hesitancy in France and Italy

Single dose of BNT162b2 vaccine after COVID provides 82% reduction in reinfection risk

Omicron breakthrough boosts neutralization titers a little more than a 3rd COVID vaccine dose

Study analyzes trends in overdose deaths from use of non-benzodiazepines and gabapentinoids

Study shows the true prevalence of statin intolerance worldwide is between 6 to 10%

Inside the tactical tug of war over the controversial Alzheimer’s drug

Two doses of psilocybin may ease depression symptoms for up to 12 months

The in vitro selection of a remdesivir-resistant SARS-CoV-2 mutation

Real-world data on efficacy and safety of COVID vaccines in Canada

Study finds Pfizer-BioNTech COVID vaccine doesn't increase pregnancy risk

Researchers identify a powerful combination of antivirals to treat COVID-19

mRNA-1273 and mRNA-1273.529 Omicron-specific boosters highly effective in mouse model

Assessing potential allergic reactions in COVID-19 vaccinated patients

Challenges in safely deprescribing common anticholinergic drugs

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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