CRISPR News and Research

Latest CRISPR News and Research

Researchers find link between increased proteostasis and immortality of stem cells

Stem cells are considered to be immortal in culture and, therefore, of great interest for aging research. This immortality is regulated by increased proteostasis, which controls the quality of proteins.

8 Mar 2018

Newly-discovered hereditary mutation leads to increased production of EPO in the blood

A newly-discovered hereditary mutation is responsible for an increased production of erythropoietin (EPO) in the blood.

8 Mar 2018

Gene-editing technology enhances T cell immunotherapies for treating cancer

Last year, the Food and Drug Administration approved the first cellular immunotherapies to treat cancer. These therapies involve collecting a patient's own immune cells -- called T cells -- and supercharging them to home in on and attack specific blood cancers, such as hard-to-treat acute lymphoblastic leukemia and non-Hodgkin lymphoma.

6 Mar 2018

New technique provides pairs of genetically matched cells to study disease

Researchers led by Dr. Knut Woltjen report a new gene editing method that can modify a single DNA base in the human genome with absolute precision.

6 Mar 2018

New and improved CRISPR

David Liu, professor of chemistry and chemical biology at Harvard University is a pioneer of CRISPR-Cas9 gene-editing technology. He has now come up with two new upgrades for this gene editing tool that makes it better than before. These two tools are “cellular detective” and “sharp scissors”.

5 Mar 2018

CRISPR enzyme can also cleave RNA, finds study

Researchers have discovered that the Cas-9 enzyme used in CRISPR gene editing can also cleave complimentary messenger RNA, in addition to DNA.

2 Mar 2018

CRISPR-like gene editing could be potential way to treat patients with harmful blood lipid levels

Using a variation of CRISPR gene editing may be a potential strategy for mimicking the protective effects of a genetic mutation linked to lower cholesterol levels and heart disease risks, according to new mouse research from the Perelman School of Medicine at the University of Pennsylvania published this week in Circulation.

28 Feb 2018

Researchers describe important step toward gene therapy for patients with Sandhoff disease

Babies with the rare, deadly genetic disorder Sandhoff disease begin to miss developmental milestones just months after birth. Lacking muscle tone, they never learn to sit up, develop heads too large to lift and eventually suffer uncontrollable seizures. There is no cure.

22 Feb 2018

Benson Hill Biosystems granted patent for novel genome editing system

The U.S. Patent and Trademark Office has granted Benson Hill Biosystems Patent No. 9,896,696 related to CRISPR 3.0 Cms1 genome editing nucleases, further expanding the company's suite of genomics tools to accelerate crop performance improvements.

20 Feb 2018

Lab-grown cerebellar cells may help explain how ASD develops at molecular level

Increasing evidence has linked autism spectrum disorder with dysfunction of the brain's cerebellum, but the details have been unclear. In a new study, researchers at Boston Children's Hospital used stem cell technology to create cerebellar cells known as Purkinje cells from patients with tuberous sclerosis complex, a genetic syndrome that often includes ASD-like features.

19 Feb 2018

Gene editing tool used to detect cancer

Researchers have developed a DNA detection system that can detect the presence of bacterial and viral DNA, which could be a valuable diagnostic tool for a range of disorders.

16 Feb 2018

Using CRISPR To Produce Induced Pluripotent Stem Cells

An interview with Dr. Sheng Ding about using a modified version of the CRISPR-Cas9 system to produce induced pluripotent stem cells.

9 Feb 2018

Scientists develop ultrasound-propelled nanomotors for active delivery of Cas9-sgRNA complex

In cancer research, the “Cas-9–sgRNA” complex is an effective genomic editing tool, but its delivery across the cell membrane to the target (tumor) genome has not yet been satisfactorily solved. American and Danish scientists have now developed an active nanomotor for the efficient transport, delivery, and release of this gene scissoring system.

9 Feb 2018

Scientists identify special pair of RNA scissors with many functions

CRISPR/Cas systems are known as promising "gene scissors" in the genome editing of plants, animals, and microorganisms by targeting specific regions in their DNA - and perhaps they can even be used to correct genetic defects.

8 Feb 2018

New CRISPR gene-editing technique can correct majority of mutations that cause DMD

Scientists have developed a CRISPR gene-editing technique that can potentially correct a majority of the 3,000 mutations that cause Duchenne muscular dystrophy (DMD) by making a single cut at strategic points along the patient's DNA, according to a study from UT Southwestern Medical Center.

6 Feb 2018

Next-generation ‘active genetics’ tool opens new horizons

In 2015, University of California San Diego biologists Ethan Bier and Valentino Gantz developed a breakthrough technology known as "active genetics," which results in parents transmitting a genetic trait to most of their offspring (instead of 50 percent receiving the trait under standard inheritance).

6 Feb 2018

Researchers report technical advances in production of HIV vaccines

Research on HIV over the past decade has led to many promising ideas for vaccines to prevent infection by the AIDS virus, but very few candidate vaccines have been tested in clinical trials.

6 Feb 2018

Novel method can edit genes with substantially fewer errors

Gene therapy is an emerging strategy to treat diseases caused by genetic abnormalities. One form of gene therapy involves the direct repair of a defective gene, using genome-editing technology such as CRISPR-Cas9. Despite its therapeutic potential, genome editing can also introduce unwanted and potentially harmful genetic errors that limit its clinical feasibility.

5 Feb 2018

The effects of Huntington’s disease can be seen as early as conception, finds new study

In a breakthrough study, scientists at the Rockefeller University have observed the effects of Huntington’s disease in neurons as early as conception.

30 Jan 2018

Rockefeller scientists develop system to model Huntington’s in human embryonic stem cells

With new findings, scientists may be poised to break a long impasse in research on Huntington's disease, a fatal hereditary disorder for which there is currently no treatment.

29 Jan 2018

CRISPR News and Research

Latest CRISPR News and Research

Researchers find link between increased proteostasis and immortality of stem cells

Newly-discovered hereditary mutation leads to increased production of EPO in the blood

Gene-editing technology enhances T cell immunotherapies for treating cancer

New technique provides pairs of genetically matched cells to study disease

New and improved CRISPR

CRISPR enzyme can also cleave RNA, finds study

CRISPR-like gene editing could be potential way to treat patients with harmful blood lipid levels

Researchers describe important step toward gene therapy for patients with Sandhoff disease

Benson Hill Biosystems granted patent for novel genome editing system

Lab-grown cerebellar cells may help explain how ASD develops at molecular level

Gene editing tool used to detect cancer

Using CRISPR To Produce Induced Pluripotent Stem Cells

Scientists develop ultrasound-propelled nanomotors for active delivery of Cas9-sgRNA complex

Scientists identify special pair of RNA scissors with many functions

New CRISPR gene-editing technique can correct majority of mutations that cause DMD

Next-generation ‘active genetics’ tool opens new horizons

Researchers report technical advances in production of HIV vaccines

Novel method can edit genes with substantially fewer errors

The effects of Huntington’s disease can be seen as early as conception, finds new study

Rockefeller scientists develop system to model Huntington’s in human embryonic stem cells

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