Chromosome News and Research

Latest Chromosome News and Research

Researchers discover gene associated with congenital anomaly of urinary tract

An interdisciplinary team of researchers under the direction of the University of Bonn Hospital have discovered a gene which is associated with a rare congenital anomaly of the urinary tract called classic bladder exstrophy.

13 Mar 2015

Understanding genetic machinery that drives malignant pediatric adrenocortical tumors

In an advance that could lead to better identification of malignant pediatric adrenocortical tumors, and ultimately to better treatment, researchers have mapped the "genomic landscape" of these rare childhood tumors. Their genomic mapping has revealed unprecedented details, not only of the aberrant genetic and chromosomal changes that drive the cancer, but the sequence of those changes that trigger it.

10 Mar 2015

Rare, aggressive subtype of pediatric acute lymphoblastic leukemia has surprisingly few mutations

The St. Jude Children's Research Hospital--Washington University Pediatric Cancer Genome Project reports that a highly aggressive form of leukemia in infants has surprisingly few mutations beyond the chromosomal rearrangement that affects the MLL gene. The findings suggest that targeting the alteration is likely the key to improved survival.

9 Mar 2015

USF researchers uncover how malaria-related parasites spread at explosive rates

A University of South Florida College of Public Health professor and his team of researchers have become the first to uncover part of the mysterious process by which malaria-related parasites spread at explosive and deadly rates inside humans and other animals.

5 Mar 2015

Genomics researchers discover novel gene variants in childhood CVID

Genomics researchers analyzing a rare, serious immunodeficiency disease in children have discovered links to a gene crucial to the body's defense against infections. The finding may represent an inviting target for drugs to treat common variable immunodeficiency (CVID).

27 Feb 2015

New study identifies genetic link to peanut allergy

Researchers have pinpointed a region in the human genome associated with peanut allergy in U.S. children, offering strong evidence that genes can play a role in the development of food allergies.

25 Feb 2015

Changes to DNA sequence associated with peanut allergy

Research funded by the National Institutes of Health suggests that changes in a small region of chromosome 6 are risk factors for peanut allergy in U.S. children of European descent. The genetic risk area is located among two tightly linked genes that regulate the presentation of allergens and microbial products to the immune system. This study is the first to use a genome-wide screening approach in patients with well-defined food allergy to identify risks for peanut allergy.

25 Feb 2015

New NCCN Guidelines for treating Acute Lymphoblastic Leukemia

According to the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Acute Lymphoblastic Leukemia (ALL), the treatment approach to ALL is one of the most complex and intensive programs in cancer therapy.

24 Feb 2015

Study: Growth hormone can improve social impairment in patients with Phelan-McDermid syndrome

A growth hormone can significantly improve the social impairment associated with autism spectrum disorder (ASD) in patients with a related genetic syndrome, according to a pilot study conducted at the Icahn School of Medicine at Mount Sinai and published yesterday on Pub Med, a public database of biomedical topics maintained by the National Institutes of Health (study originally published in the December 12 issue of the journal Molecular Autism).

20 Feb 2015

Study helps solve mystery about how genetic variations can increase cancer risk

Single-letter genetic variations within parts of the genome once dismissed as 'junk DNA' can increase cancer risk through wormhole-like effects on far-off genes, new research shows.

19 Feb 2015

Einstein researchers find possible clue to why older mothers have babies born with Down syndrome

Researchers at Albert Einstein College of Medicine of Yeshiva University have found a possible clue to why older mothers face a higher risk for having babies born with conditions such as Down syndrome that are characterized by abnormal chromosome numbers.

19 Feb 2015

Duke researchers demonstrate genetic therapeutic technique to treat DMD patients

Duke researchers have demonstrated a genetic therapeutic technique that has the potential to treat more than half of the patients suffering from Duchenne Muscular Dystrophy (DMD).

19 Feb 2015

Scientists map autism genetic pathway that regulates brain development

Scientists at the University of California, San Diego School of Medicine have found that mutations that cause autism in children are connected to a pathway that regulates brain development. The research, led by Lilia Iakoucheva, PhD, assistant professor in the Department of Psychiatry, is published in the February 18 issue of Neuron.

19 Feb 2015

New facts provide baseline for future studies of epigenome's role in human development, diseases

While genomics is the study of all of the genes in a cell or organism, epigenomics is the study of all the genomic add-ons and changes that influence gene expression but aren't encoded in the DNA sequence. A variety of new epigenomic information is now available in a collection of studies published Feb. 19 in Nature by the National Institutes of Health Roadmap Epigenomics Program.

19 Feb 2015

UT Southwestern scientists identify new biomarker that could optimize chemotherapy response

UT Southwestern Medical Center scientists have identified a new biomarker that could help identify patients who are more likely to respond to certain chemotherapies.

18 Feb 2015

Findings may help doctors recommend appropriate treatments, improve patient outcomes

Like a car's front and back bumpers, your cell's chromosomes are capped by "telomeres" that protect this genetic material against deterioration. Still, after enough replications, a chromosome's telomeres break down and once they reach a certain point of degradation, the cell dies. This is one reason that cells are mortal: telomeres only last so long. That is, unless the enzyme telomerase builds new material onto the worn telomeres to reinforce these chromosomal "bumpers". Telomere repair can be a good thing, but in some cases it's not: overactive telomerase can lengthen telomeres until a cell becomes immortal…leading to cancer.

18 Feb 2015

Chromosome News and Research

Latest Chromosome News and Research

Researchers discover gene associated with congenital anomaly of urinary tract

Understanding genetic machinery that drives malignant pediatric adrenocortical tumors

Rare, aggressive subtype of pediatric acute lymphoblastic leukemia has surprisingly few mutations

USF researchers uncover how malaria-related parasites spread at explosive rates

Genomics researchers discover novel gene variants in childhood CVID

New study identifies genetic link to peanut allergy

Changes to DNA sequence associated with peanut allergy

New NCCN Guidelines for treating Acute Lymphoblastic Leukemia

Study: Growth hormone can improve social impairment in patients with Phelan-McDermid syndrome

Study helps solve mystery about how genetic variations can increase cancer risk

Einstein researchers find possible clue to why older mothers have babies born with Down syndrome

Duke researchers demonstrate genetic therapeutic technique to treat DMD patients

Scientists map autism genetic pathway that regulates brain development

New facts provide baseline for future studies of epigenome's role in human development, diseases

UT Southwestern scientists identify new biomarker that could optimize chemotherapy response

Findings may help doctors recommend appropriate treatments, improve patient outcomes

Research may lead to future medical treatments for children with neurodevelopmental problems

TKI introduction improves French CML patient survival

Second-line bosutinib well tolerated by Japanese patients

Tissue and cell diagnostics market reaches $7.7 billion in 2014

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

Chromosome News and Research

Latest Chromosome News and Research

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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