Chromosome News and Research

Latest Chromosome News and Research

Discovery offers much needed information about how virulent insect-borne diseases cause infection

For decades, scientists have thought the bacteria that cause the bubonic plague hijack host cells at the site of a fleabite and are then taken to the lymph nodes, where the bacteria multiply and trigger severe disease. But UNC School of Medicine researchers discovered that this accepted theory is off base. The bacteria do not use host cells; they traffic to lymph nodes on their own and not in great numbers.

16 Feb 2015

Researchers develop novel strategy in fight against cancer

A team of researchers led by Associate Professor Caroline Lee from the Yong Loo Lin School of Medicine at the National University of Singapore, in collaboration with Associate Professor Song Jianxing of the Department of Biological Sciences at the NUS Faculty of Science, has developed a novel strategy in the fight against cancer.

15 Feb 2015

Scientists find seven new genes that can cause X-linked intellectual disability

X-linked intellectual disability is a disorder that predominantly affects men and can have highly variable clinical manifestations. Scientists at the Max Planck Institute for Molecular Genetics in Berlin have found seven new genes that can cause this genetic disease: Mutations of these genes on the X chromosome lead to various forms of intellectual disability.

15 Feb 2015

Longer donor leukocyte telomere length linked to improved survival following HCT

Among patients with severe aplastic anemia who received stem cell transplant from an unrelated donor, longer leukocyte (white blood cells) telomere length (a structure at the end of a chromosome) was associated with increased overall survival at 5 years, according to a study in the February 10 issue of JAMA.

12 Feb 2015

UNC researchers create new research tool to help crack the histone code

University of North Carolina scientists have created a new research tool, based on the fruit fly, to help crack the histone code. This research tool can be used to better understand the function of histone proteins, which play critical roles in the regulation of gene expression in animals and plants.

11 Feb 2015

Study links previously unknown genetic anomalies to breast cancer in African American family members

The "Jewels in our Genes" study, led by University at Buffalo researcher Heather Ochs-Balcom, has uncovered previously unknown segments of DNA shared by African American family members who have breast cancer. "The discovery of these regions supports our hypothesis that there are still undiscovered breast cancer genes that may be unique to African Americans," says Ochs-Balcom, PhD, a genetic epidemiologist in the UB Department of Epidemiology and Environmental Health.

10 Feb 2015

Duke University researchers devise new method to activate genes with light

Duke University researchers have devised a method to activate genes in any specific location or pattern in a lab dish with the flip of a light switch by crossing a bacterium's viral defense system with a flower's response to sunlight.

9 Feb 2015

Researchers develop quality assurance tool for genome editing

A research team at Boston Children's Hospital's Program in Cellular and Molecular Medicine has developed a quality assurance tool for scientists using genome-editing technologies like the increasingly popular CRISPR. The assay, called high throughput genome translocation sequencing (HTGTS), rapidly gauges—for any given gene—these technologies' accuracy and their risk for causing potentially dangerous genomic collateral damage.

9 Feb 2015

DNA strands predict life expectancy

BYU biologist Jonathan Alder has a startling secret he doesn't freely share: he knows when most of us are going to die.

9 Feb 2015

UI Children's Hospital named Certified Duchenne Care Center by PPMD

The University of Iowa Children's Hospital was named a Certified Duchenne Care Center by Parent Project Muscular Dystrophy, a nonprofit organization leading the fight to end Duchenne muscular dystrophy (Duchenne) and demanding optimal care for all people with Duchenne.

7 Feb 2015

Vanderbilt researchers find link between the biological clock and Angelman syndrome

Monitoring participants' biological clocks may be the quickest way to determine the effectiveness of experimental drugs currently under development to treat Angelman syndrome: a debilitating genetic disorder that occurs in more than one in every 15,000 live births.

6 Feb 2015

Researchers identify genetic variants associated with psoriatic arthritis

PsA is a common form of inflammatory form of arthritis causing pain and stiffness in joints and tendons that can lead to joint damage. Nearly all patients with PsA also have skin psoriasis and, in many cases, the skin disease is present before the arthritis develops. However, only one third of patients with psoriasis will go on to develop PsA.

5 Feb 2015

Cell free DNA analysis less effective than sequential screening in finding fetal chromosomal abnormalities

In a study to be presented on Feb. 5 in an oral plenary session at 8 a.m. PST, at the Society for Maternal-Fetal Medicine's annual meeting, The Pregnancy Meeting, in San Diego, researchers will report that cell free DNA analysis is less effective than sequential screening as primary testing for fetal chromosomal abnormalities.

5 Feb 2015

Alzheimer's brains commonly have many neurons with more DNA and genomic copies of APP gene

Scientists at The Scripps Research Institute have found diverse genomic changes in single neurons from the brains of Alzheimer's patients, pointing to an unexpected factor that may underpin the most common form of the disease.

5 Feb 2015

Genomics of papillary thyroid carcinoma (PTC): an interview with Professor Thomas J. Giordano

There are two types of thyroid cells and therefore there are two broad types of thyroid cancer. Medullary carcinoma is derived from parafollicular or C cells, whereas follicular cells give rise to several types of thyroid cancers.

4 Feb 2015

Study could lead to potential therapeutic targets to treat Ewing Sarcoma

A University of Colorado Cancer Center study published in the journal PLoS One finds alterations in expression of genes PIK3R3 and PTEN, more commonly observed in adult tumors, in the rare, young-adult bone cancer Ewing Sarcoma, potentially offering ways to improve therapy.

4 Feb 2015

OGT study explores successful adoption of CytoSure ISCA array at Sheffield Children's NHS Foundation Trust

Oxford Gene Technology, The Molecular Genetics Company, explores how Sheffield Children's NHS Foundation Trust has seamlessly transferred to its CytoSure ISCA 8x60k platform, in a new case study entitled Evaluating and switching to CytoSure microarrays. As the result of a highly stringent National Health Service tender for the supply of oligo-based cytogenetics research arrays, CytoSure was selected based on the quality of data and analysis software.

From Oxford Gene Technology 4 Feb 2015

Researchers reveal new pathway for inhibiting growth of tumor cells tied to BRCA mutations

Inhibiting the action of a particular enzyme dramatically slows the growth of tumor cells tied to BRCA1 and BRCA2 genetic mutations which, in turn, are closely tied to breast and ovarian cancers, according to researchers at NYU Langone Medical Center.

3 Feb 2015

Study provides common model of cellular ageing

Researchers at the BBSRC-supported Babraham Institute have mapped the physical structure of the nuclear landscape in unprecedented detail to understand changes in genomic interactions occurring in cell senescence and ageing. Their findings have allowed them to reconcile the contradictory observations of two current models of ageing: cellular senescence of connective tissue cells called fibroblasts and cellular models of an accelerated ageing syndrome.

2 Feb 2015

Scientists create largest ever catalogue of biological chimeras

Scientists from the Spanish National Cancer Research Centre's Structural Computational Biology Group, led by Alfonso Valencia, are making the largest ever catalogue of biological chimeras available to the public domain.

2 Feb 2015

Chromosome News and Research

Latest Chromosome News and Research

Discovery offers much needed information about how virulent insect-borne diseases cause infection

Researchers develop novel strategy in fight against cancer

Scientists find seven new genes that can cause X-linked intellectual disability

Longer donor leukocyte telomere length linked to improved survival following HCT

UNC researchers create new research tool to help crack the histone code

Study links previously unknown genetic anomalies to breast cancer in African American family members

Duke University researchers devise new method to activate genes with light

Researchers develop quality assurance tool for genome editing

DNA strands predict life expectancy

UI Children's Hospital named Certified Duchenne Care Center by PPMD

Vanderbilt researchers find link between the biological clock and Angelman syndrome

Researchers identify genetic variants associated with psoriatic arthritis

Cell free DNA analysis less effective than sequential screening in finding fetal chromosomal abnormalities

Alzheimer's brains commonly have many neurons with more DNA and genomic copies of APP gene

Genomics of papillary thyroid carcinoma (PTC): an interview with Professor Thomas J. Giordano

Study could lead to potential therapeutic targets to treat Ewing Sarcoma

OGT study explores successful adoption of CytoSure ISCA array at Sheffield Children's NHS Foundation Trust

Researchers reveal new pathway for inhibiting growth of tumor cells tied to BRCA mutations

Study provides common model of cellular ageing

Scientists create largest ever catalogue of biological chimeras

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

Chromosome News and Research

Latest Chromosome News and Research

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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