Gene News and Research

Latest Gene News and Research

CBL identified as the most promising potential biomarker for aortic dissection

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Aortic dissection (AD) is a fatal cardiovascular disease for which the key involved genes are largely unknown.

29 Aug 2024

Vancomycin resistance in Staphylococcus aureus may become more stable over time

Staphylococcus aureus has the potential to develop durable vancomycin resistance, according to a study published August 28, 2024, in the open-access journal PLOS Pathogens by Samuel Blechman and Erik Wright from the University of Pittsburgh, USA.

29 Aug 2024

Discovery of borderzone inflammation offers new avenues for heart failure prevention

Ischemic heart disease is the most common cause of death in the world. It begins with a "heart attack", also known as a myocardial infarction (MI), which causes part of the heart to die due to inadequate coronary blood flow.

29 Aug 2024

New bacterial defense mechanism revealed as potential tool for genome editing

Scientists who have described in a new study the step-by-step details of a bacterial defense strategy see the mechanism as a promising platform for development of a new genome-editing method.

29 Aug 2024

Study reveals key role of A20 protein in controlling inflammation in liver disease

Many individuals worldwide suffer from chronic liver disease (CLD), which poses significant concerns for its tendency to lead to hepatocellular carcinoma or liver failure. CLD is characterized by inflammation and fibrosis.

29 Aug 2024

Mapping DNA’s hidden knot-like structures may revolutionize disease treatment

Innovative study of DNA's hidden structures may open up new approaches for treatment and diagnosis of diseases, including cancer.

29 Aug 2024

AI unveils secrets of protein stability

Researchers at the Center for Algorithmic and Robotized Synthesis within the Institute for Basic Science have taken a significant step forward in understanding the stability of proteins by leveraging the power of AI. The research team used AlphaFold2 to explore how mutations affect protein stability-; a crucial factor in ensuring proteins function correctly and do not cause diseases like Alzheimer's.

29 Aug 2024

New system can spot genetic markers of autism in brain images with high accuracy

A multi-university research team co-led by University of Virginia engineering professor Gustavo K. Rohde has developed a system that can spot genetic markers of autism in brain images with 89 to 95% accuracy.

28 Aug 2024

Study reveals a new target for universal treatment for autoimmune diseases

More than two decades ago, a research team in the lab of David Hafler, a Yale researcher who at the time was at Harvard, discovered a type of T cell in humans that suppresses the immune system; they later found that these so-called regulatory T cells, when defective, are an underlying cause of autoimmune disease, specifically multiple sclerosis (MS).

28 Aug 2024

Study reveals how bacteria pass on traits without DNA changes

Bacterial cells can "remember" brief, temporary changes to their bodies and immediate surroundings, a new Northwestern University and University of Texas-Southwestern study has found.

28 Aug 2024

16 promising postdoctoral scientists awarded Damon Runyon Fellowships for cancer research

The Damon Runyon Cancer Research Foundation has named 16 new Damon Runyon Fellows, exceptional postdoctoral scientists conducting basic and translational cancer research in the laboratories of leading senior investigators.

28 Aug 2024

Breakthrough vaccine targets tick-borne bovine anaplasmosis in cattle

University of Missouri researchers are working to develop the first-ever vaccine proven to protect cattle from a devastating tick-borne cattle disease known as bovine anaplasmosis.

28 Aug 2024

Hereditary cardiac amyloidosis more common in the UK than previously thought

More people in the UK are at risk of a hereditary form of cardiac amyloidosis, a potentially fatal heart condition, than previously thought, according to a new study led by researchers at UCL (University College London) and Queen Mary University of London.

28 Aug 2024

CDCA7 identified as key player in hemimethylation sensing

DNA methylation is a process in which a methyl group is attached to the cytosine base of the DNA molecule, and a major way that DNA is epigenetically marked.

28 Aug 2024

Cell therapy commercialization: Streamline your path to cell therapy commercialization

Moving your cell therapy clinical trial beyond Phase I is an exciting time, marking a significant milestone. There are many therapeutic developers working to address critical patient needs in oncology, auto-immune, regenerative medicine, and other spaces.

From Charles Rivers Laboratories Cell and Gene Therapy 28 Aug 2024

Study identifies genetic cause of severe seizures in children

Shortly after Kelly Cervantes' daughter Adelaide was born, she started having terrible seizures. Doctors were unable to give her a solution, or even a cause.

28 Aug 2024

Benefits of less intensive stem cell transplants for sickle cell disease

So-called low-intensity blood stem cell transplants, which use milder conditioning agents than standard stem cell transplants, do not appear to damage the lungs and may help improve lung function in some patients with sickle cell disease (SCD), according to a three-year study of adults who underwent the procedure at the National Institutes of Health (NIH).

28 Aug 2024

PET imaging and proteomics reveal distinct protein signatures in Alzheimer's disease progression

Researchers used PET imaging and proteomic analysis of cerebrospinal fluid to study amyloid β and tau tangle loads in Alzheimer's patients, identifying 127 proteins linked to disease progression. The findings highlight distinct molecular pathways and potential therapeutic targets.

28 Aug 2024

Zbtb18 regulates cKit expression for HSC self renewal

The study addresses the complex regulation of HSCs, highlighting p21's multifunctional nature beyond cell cycle control. Through the use of p21-tdTomato mice, researchers differentiate between p21-tdT+ and p21-tdT− HSCs. Results show that p21-tdT+ HSCs display increased self-renewal and reconstitution abilities. Zbtb18, upregulated in p21-tdT+ HSCs, is crucial for their repopulation capability. p21 interacts with ZBTB18 to suppress cKit, influencing HSC self-renewal.

28 Aug 2024

LncRNA ZNF593-AS offers hope for heart disease treatment

The research presented in the article delves into the regulatory role of the long non-coding RNA (lncRNA) ZNF593-AS in cardiac hypertrophy and myocardial remodeling, processes that are pivotal in the progression of heart failure and other cardiovascular diseases. The study uncovers how ZNF593-AS exerts its inhibitory effects by upregulating the expression of Mitofusin 2 (Mfn2), a protein known for its role in the regulation of mitochondrial dynamics and cellular metabolism.

28 Aug 2024