Gene News and Research

Latest Gene News and Research

PET imaging and proteomics reveal distinct protein signatures in Alzheimer's disease progression

Researchers used PET imaging and proteomic analysis of cerebrospinal fluid to study amyloid β and tau tangle loads in Alzheimer's patients, identifying 127 proteins linked to disease progression. The findings highlight distinct molecular pathways and potential therapeutic targets.

28 Aug 2024

Zbtb18 regulates cKit expression for HSC self renewal

The study addresses the complex regulation of HSCs, highlighting p21's multifunctional nature beyond cell cycle control. Through the use of p21-tdTomato mice, researchers differentiate between p21-tdT+ and p21-tdT− HSCs. Results show that p21-tdT+ HSCs display increased self-renewal and reconstitution abilities. Zbtb18, upregulated in p21-tdT+ HSCs, is crucial for their repopulation capability. p21 interacts with ZBTB18 to suppress cKit, influencing HSC self-renewal.

28 Aug 2024

LncRNA ZNF593-AS offers hope for heart disease treatment

The research presented in the article delves into the regulatory role of the long non-coding RNA (lncRNA) ZNF593-AS in cardiac hypertrophy and myocardial remodeling, processes that are pivotal in the progression of heart failure and other cardiovascular diseases. The study uncovers how ZNF593-AS exerts its inhibitory effects by upregulating the expression of Mitofusin 2 (Mfn2), a protein known for its role in the regulation of mitochondrial dynamics and cellular metabolism.

28 Aug 2024

$120 million gift boosts UCLA’s efforts in immunotherapy and innovation

UCLA has received a $120 million commitment from surgeon, inventor and philanthropist Dr. Gary Michelson and his wife, Alya, to kick-start the California Institute for Immunology and Immunotherapy, an innovative public-private partnership aimed at spurring breakthrough discoveries that prevent and cure diseases and catalyze economic growth and innovation in Los Angeles.

27 Aug 2024

Scientists discover how a gut insulin antagonist controls fat loss in C. elegans by modulating brain signals

Researchers have identified an endogenous insulin antagonist, INS-7, in Caenorhabditis elegans that modulates fat loss by inhibiting a gut-to-brain signaling pathway involving the neuropeptide FLP-7.

27 Aug 2024

Study illuminates CDCA7's role in DNA methylation

DNA methylation, a process by which methyl groups are added to DNA molecules, is essential for the maintenance of DNA and the overall health of an organism.

27 Aug 2024

Study reveals a rare genotype with significant impact on women's health

Scientists at deCODE genetics and collaborators, have identified a sequence variant in the CCDC201 gene that when inherited from both parents homozygous causes menopause on average nine years earlier.

27 Aug 2024

New techniques in RNA engineering promise longer-lasting therapies

New methods to shape RNA molecules into circles could lead to more effective and long-lasting therapies, shows a study by researchers at the University of California San Diego.

27 Aug 2024

With only gloves to protect them, farmworkers say they tend sick cows amid bird flu

In early August, farmworkers gathered under a pavilion at a park here for a picnic to celebrate Farmworker Appreciation Day. One sign that this year was different from the others was the menu: Beef fajitas, tortillas, pico de gallo, chips, beans — but no chicken.

27 Aug 2024

New benchmark: 1 kg of plasmid DNA manufactured

Kaneka Eurogentec sets new benchmark in plasmid DNA manufacturing with the production of 1 kg of plasmid DNA.

From Kaneka Eurogentec S.A 27 Aug 2024

The significance of CHEK2 variants in cancer risk assessment

A new editorial was published in Oncotarget's Volume 15 on July 10, 2024, entitled, "Genotype matters: Personalized screening recommendations for germline CHEK2 variants."

27 Aug 2024

Austocystin D's anticancer efficacy linked to CYP2J2 enzyme activity

Austocystin D, a natural compound produced by fungi, has been recognized for its cytotoxic effects and anticancer activity in various cell types. It exhibits potent activity even in cells that express proteins associated with multidrug resistance, attracting significant global research interest.

27 Aug 2024

Stem cell study identifies unique glial contributions to multiple sclerosis

A team of scientists from The New York Stem Cell Foundation (NYSCF) Research Institute and Case Western Reserve University has created the largest reported collection of stem cell models from multiple sclerosis (MS) patients and used them to identify unique ways in which glia – integral support cells in the brain – contribute to the disease.

26 Aug 2024

Engineered human cardiac tissue reveals how lupus autoantibodies damage the heart

Study demonstrates that autoantibodies in systemic lupus erythematosus (SLE) patients contribute to myocardial injury by binding to and impairing stressed cardiac cells, offering insights into potential therapeutic targets.

25 Aug 2024

Study reveals metabolic switch crucial for memory T cell formation and cancer immunity

A Ludwig Cancer Research study has identified a metabolic switch in the immune system's T cells that is essential to the generation of memory T cells-;which confer lasting immunity to previously encountered pathogens-;and a T cell subtype found in tumors that drives anti-tumor responses during immunotherapy.

23 Aug 2024

Wake Forest Institute for Regenerative Medicine joins new NSF-funded pandemic prediction initiative

The Wake Forest Institute for Regenerative Medicine is proud to be part of a new initiative, supported by an $18 million grant from the U.S. National Science Foundation (NSF), aimed at enhancing global pandemic prediction and prevention capabilities.

23 Aug 2024

Integrating laboratory and field data to model plant circadian clock responses

Much of what we know about plant circadian rhythms is the result of laboratory experiments where inputs such as light and temperature can be tightly controlled.

23 Aug 2024

Innovations in biomarker detection and personalized medicine for prostate cancer

In a recent comprehensive review published in Cyborg Bionic Systems, researchers led by Keyi Li from the General Hospital of Northern Theater Command in Shenyang, along with international collaborators, detail significant advances in the identification and application of biomarkers for prostate cancer (PCa).

23 Aug 2024

Improved governance and pre-release safety evaluations needed for biological AI models

Concerns over the biosecurity risks posed by artificial intelligence (AI) models in biology continue to grow.

23 Aug 2024

Unique strain of probiotic bacteria shows potential in combating inflammatory diseases

There is a critical unmet need to help tighten and maintain a healthy intestinal barrier and treat a leaky gut. Researchers have now found that a unique strain of probiotic bacteria, Bifidobacterium bifidum BB1, enhances intestinal barrier function and protects against penetration of bacteria and various harmful agents in the intestine.

23 Aug 2024

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Gene News and Research

Latest Gene News and Research

PET imaging and proteomics reveal distinct protein signatures in Alzheimer's disease progression

Zbtb18 regulates cKit expression for HSC self renewal

LncRNA ZNF593-AS offers hope for heart disease treatment

$120 million gift boosts UCLA’s efforts in immunotherapy and innovation

Scientists discover how a gut insulin antagonist controls fat loss in C. elegans by modulating brain signals

Study illuminates CDCA7's role in DNA methylation

Study reveals a rare genotype with significant impact on women's health

New techniques in RNA engineering promise longer-lasting therapies

With only gloves to protect them, farmworkers say they tend sick cows amid bird flu

New benchmark: 1 kg of plasmid DNA manufactured

The significance of CHEK2 variants in cancer risk assessment

Austocystin D's anticancer efficacy linked to CYP2J2 enzyme activity

Stem cell study identifies unique glial contributions to multiple sclerosis

Engineered human cardiac tissue reveals how lupus autoantibodies damage the heart

Study reveals metabolic switch crucial for memory T cell formation and cancer immunity

Wake Forest Institute for Regenerative Medicine joins new NSF-funded pandemic prediction initiative

Integrating laboratory and field data to model plant circadian clock responses

Innovations in biomarker detection and personalized medicine for prostate cancer

Improved governance and pre-release safety evaluations needed for biological AI models

Unique strain of probiotic bacteria shows potential in combating inflammatory diseases

eBook: Using iPSCs models for human disease research and drug discovery eBook

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production