Huntington's Disease News and Research

Latest Huntington's Disease News and Research

New way of understanding neurodegeneration may lead to novel treatments

University of Adelaide researchers have developed a new theory for the causes of dementia and other neurodegenerative diseases, involving an out-of-control immune system.

13 May 2016

Key gene changes reveal four previously unknown conditions within schizophrenia

Changes in key genes clearly define four previously unknown conditions within the umbrella diagnosis of schizophrenia, according to a study led by researchers from NYU Langone Medical Center published online April 28 in EBioMedicine, a Lancet journal. Cases associated with changes in each of the four genes were different from each other in terms of symptoms, intelligence level and other disease features.

29 Apr 2016

Innovative strategy can reverse symptoms in neurodegenerative diseases

Alzheimer's and Parkinson's disease are the two most common neurodegenerative disorders worldwide and cause untold suffering to millions of patients and their families. Treatments for these diseases are limited, and no cures exist. Now, a new study describes an innovative strategy that reverses symptoms in these neurodegenerative diseases - at least in fruit flies which had been genetically altered to model the diseases.

26 Apr 2016

Scientists discover CD2AP protein that plays key role in nervous system

University of Louisville researchers have discovered that a protein previously known for its role in kidney function also plays a significant role in the nervous system. In an article featured in the April 13 issue of the Journal of Neuroscience, they show that the adaptor protein CD2AP is a key player in a type of neural growth known as collateral sprouting.

21 Apr 2016

Irvine neurobiologists find new way to change damaging course of Huntington disease

A study appearing April 14 in the journal Neuron suggests there may be a new way to change the damaging course of Huntington disease.

18 Apr 2016

Glial cells can modulate specific nerve endings in the brain, find Rockefeller scientists

More than half of our brains are made up of glial cells, which wrap around nerve fibers and insulate them--similarly to how the plastic casing of an electric cable insulates the copper wire within--allowing electrical and chemical impulses to travel faster.

12 Apr 2016

Rockefeller scientists study molecular mechanism that causes linker cell death in worms

Some cells are meant to live, and some are meant to die. The linker cell of Caenorhabditis elegans, a tiny worm that is a favored model organism for biologists, is among those destined for termination.

11 Apr 2016

Commonly used fungicides could cause gene expression changes in brain cells

Scientists at the UNC School of Medicine have found a class of commonly used fungicides that produce gene expression changes similar to those in people with autism and neurodegenerative conditions, including Alzheimer's disease and Huntington's disease.

31 Mar 2016

Findings offer novel way for creating drugs to stop mitochondria from destroying cells during stress

Malfunctioning mitochondria — the power plants in cells — are behind the damage caused by strokes, heart attacks, and neurodegenerative diseases, but little has been known about how to stop these reactors from melting down, destroying cells and tissue. Mitochondria also take up calcium, which regulates energy production.

11 Mar 2016

New drug shows promise against Huntington's disease

A drug that would be the first to target the cause of Huntington's disease (HD) is effective and safe when tested in mice and monkeys, according to data released today that will be presented at the American Academy of Neurology's 68th Annual Meeting in Vancouver, Canada, April 15 to 21, 2016.

27 Feb 2016

Sangamo presents immunological data from SB-728-T HIV clinical study at CROI 2016

Sangamo BioSciences, Inc., the leader in therapeutic genome editing, announced the presentation of immunological data from the Company's clinical trials of SB-728-T, a ZFP Therapeutic designed to provide functional control of HIV.

25 Feb 2016

Revealing dynamic protein complexes with NMR: an interview with Elisar Barbar

Most proteins are involved in interactions with one or a few functional ligands, but some proteins, like light chain 8 (LC8), have numerous binding partners. LC8 interacts with more than 100 functionally different proteins, from viral proteins to motor proteins to proteins involved in cell division.

From Bruker BioSpin - NMR, EPR and Imaging 18 Feb 2016

Synthetic RNA and DNA could reverse protein deficiency that causes Friedreich's ataxia

Researchers at UT Southwestern Medical Center have identified synthetic RNA and DNA that reverses the protein deficiency causing Friedreich's ataxia, a neurological disease for which there is currently no cure.

17 Feb 2016

TSRI scientists receive $1.7 million NIH grant to find new target for treating Huntington's disease

Scientists from the Florida campus of The Scripps Research Institute have won nearly $1.7 million from the National Institutes of Health's National Institute of Neurological Disorders and Stroke to investigate the mechanisms that contribute to Huntington's disease, a fatal inherited disease that some have described as having ALS, Parkinson's and Alzheimer's--at the same time.

12 Feb 2016

FDA clears Sangamo BioSciences' SB-318 IND application for treatment of MPS I

Sangamo BioSciences, Inc., the leader in therapeutic genome editing, announced that the U.S. Food and Drug Administration has cleared the Company's Investigational New Drug (IND) application for SB-318, a single treatment strategy intended to provide a life-long therapy for Mucopolysaccharidosis Type I (MPS I).

8 Feb 2016

Lamin nucleoskeleton disordered in Alzheimer's

Brain cell death in Alzheimer's disease is linked to disruption of a skeleton that surrounds the nucleus of the cells, a researcher in the School of Medicine at The University of Texas Health Science Center at San Antonio said.

5 Feb 2016

Study finding could shed light on molecular mechanisms underlying Huntington's disease

Researchers at the University of Pittsburgh School of Medicine have shown that the core of the protein clumps found in the brains of people with Huntington's disease have a distinctive structure, a finding that could shed light on the molecular mechanisms underlying the neurodegenerative disorder.

4 Feb 2016

FDA grants Orphan Drug Designation to Ionis Pharmaceuticals' IONIS-HTT Rx for treatment of HD patients

Ionis Pharmaceuticals, Inc. today announced that the U.S. Food and Drug Administration has granted Orphan Drug Designation to IONIS-HTTRx for the treatment of patients with Huntington's disease (HD).

5 Jan 2016

Sangamo presents Phase 2 data from two ongoing clinical trials of SB-728-T for treatment of HIV/AIDS

Sangamo BioSciences, Inc., the leader in therapeutic genome editing, announced the presentation of Phase 2 data from two of the Company's ongoing clinical trials (SB-728-1101 Cohort 3* and SB-728-mR-1401) of SB-728-T, which is being developed for the functional control of HIV/AIDS.

11 Dec 2015

Tetra begins human Phase 1 safety trials of BPN14770

Tetra Discovery Partners today announced that the company has initiated human Phase 1 safety trials of its lead compound BPN14770, which Tetra is developing as a potential treatment to both improve memory and slow the progression of Alzheimer's disease.

9 Dec 2015

Huntington's Disease News and Research

Latest Huntington's Disease News and Research

New way of understanding neurodegeneration may lead to novel treatments

Key gene changes reveal four previously unknown conditions within schizophrenia

Innovative strategy can reverse symptoms in neurodegenerative diseases

Scientists discover CD2AP protein that plays key role in nervous system

Irvine neurobiologists find new way to change damaging course of Huntington disease

Glial cells can modulate specific nerve endings in the brain, find Rockefeller scientists

Rockefeller scientists study molecular mechanism that causes linker cell death in worms

Commonly used fungicides could cause gene expression changes in brain cells

Findings offer novel way for creating drugs to stop mitochondria from destroying cells during stress

New drug shows promise against Huntington's disease

Sangamo presents immunological data from SB-728-T HIV clinical study at CROI 2016

Revealing dynamic protein complexes with NMR: an interview with Elisar Barbar

Synthetic RNA and DNA could reverse protein deficiency that causes Friedreich's ataxia

TSRI scientists receive $1.7 million NIH grant to find new target for treating Huntington's disease

FDA clears Sangamo BioSciences' SB-318 IND application for treatment of MPS I

Lamin nucleoskeleton disordered in Alzheimer's

Study finding could shed light on molecular mechanisms underlying Huntington's disease

FDA grants Orphan Drug Designation to Ionis Pharmaceuticals' IONIS-HTT Rx for treatment of HD patients

Sangamo presents Phase 2 data from two ongoing clinical trials of SB-728-T for treatment of HIV/AIDS

Tetra begins human Phase 1 safety trials of BPN14770

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

Huntington's Disease News and Research

Latest Huntington's Disease News and Research

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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