Metabolism News and Research

Latest Metabolism News and Research

Improved IVF success with the Mediterranean diet, study shows

Review highlights that adherence to the Mediterranean diet may improve clinical pregnancy and live birth rates in couples undergoing assisted reproduction, though findings are inconsistent, and more research is needed.

27 Aug 2024

Scientists discover how a gut insulin antagonist controls fat loss in C. elegans by modulating brain signals

Researchers have identified an endogenous insulin antagonist, INS-7, in Caenorhabditis elegans that modulates fat loss by inhibiting a gut-to-brain signaling pathway involving the neuropeptide FLP-7.

27 Aug 2024

NIDDK Catalyst Award funds research on mammary gland's role in metabolic diseases

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Catalyst Award program has awarded a $4 million, five-year grant to Prashant Rajbhandari, PhD, Assistant Professor of Medicine (Endocrinology, Diabetes and Bone Disease) at the Mount Sinai Diabetes, Obesity, and Metabolism Institute, to investigate a new frontier in understanding metabolic diseases like obesity and type 2 diabetes.

27 Aug 2024

FDA-approved Alzheimer's drug induces torpor-like state in tadpoles

27 Aug 2024

How diet shapes gut microbiota and affects brain function

Researchers discuss the diet-microbiota-gut-brain axis, which describes the role of both diet and gut microbiota composition on cognitive and emotional health.

26 Aug 2024

GLP-1 therapy boosts visceral fat metabolism, driving weight loss

Researchers discuss the role of enhanced visceral adipose tissue metabolism in mediating weight loss by glucagon-like peptide-1 drugs.

26 Aug 2024

Diabetes rates surge 18.6% in the U.S., highlighting racial and economic disparities

Researchers evaluate national trends and disparities in the prevalence of diabetes among adults in the United States.

25 Aug 2024

Study reveals metabolic switch crucial for memory T cell formation and cancer immunity

A Ludwig Cancer Research study has identified a metabolic switch in the immune system's T cells that is essential to the generation of memory T cells-;which confer lasting immunity to previously encountered pathogens-;and a T cell subtype found in tumors that drives anti-tumor responses during immunotherapy.

23 Aug 2024

Study reveals negative health consequences of sleep disruption for overweight individuals

New research from Oregon Health & Science University reveals negative health consequences for people who are overweight and ignore their body's signals to sleep at night, with specific differences between men and women.

23 Aug 2024

Maternal gut bacteria linked to changes in fetal brain metabolism

The impact of Bifidobacterium breve's presence in the maternal gut during pregnancy on fetal brain metabolism.

23 Aug 2024

Exploring the impact of thyroid hormone on brain function

Thyroid hormone plays a key role in regulating a range of physiologic functions, including metabolism, temperature, heart rate, and growth. It accomplishes this impressive array of activities by interacting with almost every organ system in the body. Yet despite a long history of research on how thyroid hormone influences different organs, its effects on arguably the most crucial organ -; the brain -; have remained shrouded in mystery.

23 Aug 2024

FDA-approved drug could revolutionize organ transplantation

Researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University report that they were able to successfully put tadpoles of Xenopus laevis frogs into a hibernation-like torpor state using donepezil (DNP), a drug approved by the FDA to treat Alzheimer's. The team had previously used another drug, SNC80, to achieve similar results in tadpoles and enhance the survival of whole mammalian hearts for transplants, but SNC80 is not approved for clinical use in humans because it can cause seizures. By contrast, DNP is already being used in the clinic, meaning it potentially could be rapidly repurposed for use in emergency situations to prevent irreversible organ injury while a person is being transported to a hospital.

23 Aug 2024

Immune cells' two-pronged approach to maintaining acetyl-CoA reserves

Immune cells use two different routes to produce acetyl-CoA, an essential metabolite required to fight infection and cancer, reports a study led by Van Andel Institute scientists.

23 Aug 2024

SCARB2 deficiency disrupts bile acid metabolism and gut microbiome

The study details the connection between SCARB2 deficiency and gastrointestinal dysfunction, revealing that the loss of SCARB2 leads to alterations in bile acid metabolism and dysbiosis in the gut microbiome. This disruption affects the signaling pathway involving FXR, which normally regulates bile acid synthesis and intestinal lipid absorption. The hyperactive FXR in Scarb2-deficient mice leads to a decrease in epithelial cell turnover and lipid malabsorption, particularly impacting the absorption of vitamin E, which is crucial for maintaining neurological health. The researchers further explored the impact of these changes on the gut-liver axis and found alterations in the expression of genes related to bile acid synthesis.

23 Aug 2024

Kynurenine pathway blockade shows promise for restoring brain metabolism in Alzheimer's

Among the many ways neuroscientists think Alzheimer's disease may strip away brain function is by disrupting the glucose metabolism needed to fuel the healthy brain.

22 Aug 2024

New insights into macrophages' role in MASH and liver fibrosis

Formerly known as nonalcoholic steatohepatitis, metabolic dysfunction-associated steatohepatitis (MASH) is an inflammatory disease characterized by liver scarring or fibrosis that progressively impairs liver function.

22 Aug 2024

Cancer drug holds promise as a new treatment for neurodegenerative diseases

A type of drug developed for treating cancer holds promise as a new treatment for neurodegenerative diseases such as Alzheimer's, according to a recent study by researchers at Penn State, Stanford University and an international team of collaborators.

22 Aug 2024

Metabolism News and Research

Latest Metabolism News and Research

Improved IVF success with the Mediterranean diet, study shows

Scientists discover how a gut insulin antagonist controls fat loss in C. elegans by modulating brain signals

NIDDK Catalyst Award funds research on mammary gland's role in metabolic diseases

FDA-approved Alzheimer's drug induces torpor-like state in tadpoles

How diet shapes gut microbiota and affects brain function

GLP-1 therapy boosts visceral fat metabolism, driving weight loss

Diabetes rates surge 18.6% in the U.S., highlighting racial and economic disparities

Study reveals metabolic switch crucial for memory T cell formation and cancer immunity

Study reveals negative health consequences of sleep disruption for overweight individuals

Maternal gut bacteria linked to changes in fetal brain metabolism

Exploring the impact of thyroid hormone on brain function

FDA-approved drug could revolutionize organ transplantation

Immune cells' two-pronged approach to maintaining acetyl-CoA reserves

SCARB2 deficiency disrupts bile acid metabolism and gut microbiome

Kynurenine pathway blockade shows promise for restoring brain metabolism in Alzheimer's

New insights into macrophages' role in MASH and liver fibrosis

Cancer drug holds promise as a new treatment for neurodegenerative diseases

Study shows frequent mitochondrial DNA insertion in the brain cells

Long-term low-dose cannabis reverses brain aging in mice

Mother's gut bacteria during pregnancy promote healthy brain development in the fetus

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production