Neuroblastoma News and Research

Latest Neuroblastoma News and Research

Researchers identify molecular pathway that causes immune cells to promote cancer

Investigators at the Children's Center for Cancer and Blood Diseases at Children's Hospital Los Angeles have identified new findings about an immune cell - called a tumor-associated macrophage - that promotes cancer instead of fighting it.

21 Sep 2017

Researchers identify protein that offers likely target for treating high-risk pediatric cancers

Oncology researchers studying high-risk children's cancers have identified a protein that offers a likely target for immunotherapy--harnessing the immune system in medical treatments. In cell cultures and animal models, a potent drug attached to an antibody selectively zeroes in on cancer cells without harming healthy cells.

11 Sep 2017

Scientist receives NIH grant to investigate tumor microenvironment from relatively new context

Cancer metastasis – the spread of disease from the original site to a distant organ – remains a major challenge in treating cancer and a main cause of morbidity and mortality.

6 Sep 2017

Mayo Clinic research clarifies relationship between two genes that fuel neuroblastoma spread

For the first time, Mayo Clinic researchers and colleagues present data on how nervous system tumors, called neuroblastomas, spread. Their paper, published in Cancer Cell, clarifies the relationship between two genes that fuel the aggressive spread of neuroblastomas.

1 Sep 2017

St. Jude creates world’s largest collection of pediatric solid tumor samples

In an effort to improve outcomes for patients with some of the deadliest childhood cancers, St. Jude Children's Research Hospital scientists have created the world's largest collection of pediatric solid tumor samples, drug-sensitivity data and related information and have made the resource available at no charge to the global scientific community.

31 Aug 2017

Complex sugar molecules could help in early detection of tumors

Scientists from the University of Würzburg have synthesized a complex sugar molecule which specifically binds to the tumor protein Galectin-1. This could help to recognize tumors at an early stage and to combat them in a targeted manner.

14 Aug 2017

New biomarker assay improves detection, assessment of neuroblastoma

Investigators at The Saban Research Institute of Children's Hospital Los Angeles have developed and tested a new biomarker assay for quantifying disease and detecting the presence of neuroblastoma even when standard evaluations yield negative results for the disease.

23 Jun 2017

Could a blood test predict how cancer spreads in children?

Traditionally, we use biopsies to try to predict how cancer spreads. There are a number of molecular markers that are used, but biopsy is a limited approach. Now, the current trend is to use liquid biopsy, which is basically a blood sample.

21 Jun 2017

Research findings lay groundwork for developing more targeted treatments for deadly neuroblastomas

Genetic variations appear to pre-dispose children to developing certain severe forms of neuroblastoma, according to new research by the University of Chicago Medicine. The findings lay the groundwork for developing more targeted treatments for particularly deadly variations of the cancer.

20 Jun 2017

Findings may contribute to better understanding of aging and cancer development

A team of researchers led by Dr. Dennis Kappei, a Special Fellow from the Cancer Science Institute of Singapore at the National University of Singapore, has discovered the role of the protein ZBTB48 in regulating both telomeres and mitochondria, which are key players involved in cellular aging.

14 Jun 2017

Study finds steady decline in severe health problems for childhood cancer survivors

Treatments for childhood cancer are often intense and carry the risk of lifelong health problems for survivors. An analysis of 23,600 childhood cancer survivors in the Childhood Cancer Survivor Study (CCSS), funded by the National Institutes of Health, found that the rate of severe health problems occurring five or more years after diagnosis has declined over time.

5 Jun 2017

Researchers identify genetic mutations that predict better prognosis for neuroblastoma patients

The annual mortality rate in childhood cancer of the sympathetic nervous system, or neuroblastoma, is 10 per million between the ages of 0 and 4. The collaborative work between Basque and Valencian researchers has served to identify some genetic mutations that will help to improve the treatment of this disease.

19 May 2017

New trial aims to prolong remission for pediatric leukemia patients treated with T-cell immunotherapy

After phase 1 results of Seattle Children's Pediatric Leukemia Adoptive Therapy trial have shown T-cell immunotherapy to be effective in getting 93 percent of patients with relapsed or refractory acute lymphoblastic leukemia into complete initial remission, researchers have now opened a first-in-human clinical trial aimed at reducing the rate of relapse after the therapy, which is about 50 percent.

9 May 2017

Researcher finds new ways to adapt corn protein-based drug delivery method to pediatric medications

Developing medications for children can be challenging—taste and texture are important, but safety is also a major concern, according to pharmaceutical sciences professor Om Perumal at South Dakota State University.

13 Feb 2017

New treatment prevents chemotherapy-induced hearing loss in children with cancer

Investigators from Children's Hospital Los Angeles and 37 other Children's Oncology Group hospitals in the U.S. and Canada have determined that sodium thiosulfate prevents cisplatin-induced hearing loss in children and adolescents with cancer.

2 Dec 2016

Study finds lack of improvement in health status of childhood cancer survivors

Long-term survivors of childhood cancer live longer thanks to improvements to cancer treatments, but a new study looking at three decades of therapy suggests patients do not report better health status.

8 Nov 2016

CHLA receives grant to study effects of chemoimmunotherapy in childhood neuroblastoma

A team of investigators at Children's Hospital Los Angeles has received a major, three-year grant from the V Foundation for Cancer Research to study the effects of chemoimmunotherapy in children with neuroblastoma.

18 Oct 2016

Study suggests possibility for small molecule drug/antibody combinatorial therapy to treat neuroblastoma

A study by a multidisciplinary team of researchers from The Saban Research Institute of Children's Hospital Los Angeles sheds further light on the role of the cytokine TGFβ1 in the growth of neuroblastoma, and suggests the possibility for a small molecule drug/antibody combinatorial therapy to treat this cancer.

12 Oct 2016

Aggressive neuroblastoma contains specific protein not found in benign forms of cancer

Aggressive forms of neuroblastoma contain a specific protein in their cells' nuclei that is not found in the nuclei of more benign forms of the cancer, and the discovery, made through research from the University of Rochester Medical Center, could lead to new forms of targeted therapy.

6 Oct 2016

GDE2 protein could help predict course of neuroblastoma

The research group of Wouter Moolenaar of the Netherlands Cancer Institute (NKI) has, in collaboration with the group of Rogier Versteeg of the AMC Amsterdam, discovered a protein that can predict the course of neuroblastoma.

4 Oct 2016

Neuroblastoma News and Research

Latest Neuroblastoma News and Research

Researchers identify molecular pathway that causes immune cells to promote cancer

Researchers identify protein that offers likely target for treating high-risk pediatric cancers

Scientist receives NIH grant to investigate tumor microenvironment from relatively new context

Mayo Clinic research clarifies relationship between two genes that fuel neuroblastoma spread

St. Jude creates world’s largest collection of pediatric solid tumor samples

Complex sugar molecules could help in early detection of tumors

New biomarker assay improves detection, assessment of neuroblastoma

Could a blood test predict how cancer spreads in children?

Research findings lay groundwork for developing more targeted treatments for deadly neuroblastomas

Findings may contribute to better understanding of aging and cancer development

Study finds steady decline in severe health problems for childhood cancer survivors

Researchers identify genetic mutations that predict better prognosis for neuroblastoma patients

New trial aims to prolong remission for pediatric leukemia patients treated with T-cell immunotherapy

Researcher finds new ways to adapt corn protein-based drug delivery method to pediatric medications

New treatment prevents chemotherapy-induced hearing loss in children with cancer

Study finds lack of improvement in health status of childhood cancer survivors

CHLA receives grant to study effects of chemoimmunotherapy in childhood neuroblastoma

Study suggests possibility for small molecule drug/antibody combinatorial therapy to treat neuroblastoma

Aggressive neuroblastoma contains specific protein not found in benign forms of cancer

GDE2 protein could help predict course of neuroblastoma

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

Neuroblastoma News and Research

Latest Neuroblastoma News and Research

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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