Pharmacology News and Research

Latest Pharmacology News and Research

Research finding may offer novel path for cancer drug design

Genetic mutations aren't the only thing that can keep a protein called PTEN from doing its tumor-suppressing job. Johns Hopkins researchers have now discovered that four small chemical tags attached (reversibly) to the protein's tail can have the same effect, and they say their finding may offer a novel path for drug design to keep PTEN working.

10 Jul 2013

p53 restoration of function drug candidate: an interview with Dr. Wayne Danter, MD, FRCPC President and CEO of Critical Outcome Technologies

COTI-2 is a computer-designed small molecule that was discovered by our artificial intelligence drug discovery platform called CHEMSAS.

8 Jul 2013

Study shows activated blood platelets enable cancer cells to penetrate blood vessels

Malignant tumours often spread to remote areas of the body. In the majority of cases, metastases formation develops via the blood vascular system. The blood platelets thereby provide invaluable help to the tumour cells in penetrating new organs.

4 Jul 2013

CTI announces publication of preclinical, clinical data for pacritinib in Drugs of the Future 2013

Cell Therapeutics, Inc. today announced that a comprehensive article summarizing preclinical and clinical data for pacritinib, an oral JAK2/FLT3 inhibitor, authored by Srdan Verstovsek, M.D., Ph.D., et al., was published in the journal Drugs of the Future 2013.

3 Jul 2013

NIDA grants $3.3M to design vaccine conferring immunity to nicotine

A chemical component present in the nightshade family of plants is one of the world's most tenaciously addictive substances. It is the nicotine contained in tobacco and found in high concentrations in cigarettes. Smoking remains a global scourge; in the U.S. it is the leading source of preventable death.

3 Jul 2013

Salsalate lowers blood glucose and improves glycemic control in T2D, say scientists

Joslin scientists report that salsalate, a drug used to treat arthritis, lowers blood glucose and improves glycemic control in type 2 diabetes. These findings, which were published today by the Annals of Internal Medicine, provide additional evidence that salsalate may be an effective drug to treat type 2 diabetes.

3 Jul 2013

UCLA researchers introduce gene therapy technique to treat sickle cell disease

Researchers at UCLA's Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research have successfully established the foundation for using hematopoietic (blood-producing) stem cells from the bone marrow of patients with sickle cell disease to treat the disease.

2 Jul 2013

Research shows DHA found in fish oil can reduce inflammation

Bethesda, MD-Chronic inflammation is a major factor in a wide range of problems from arthritis to cardiovascular disease, and DHA (found in fish oil) is known to temper this problem. A new research report appearing in the July 2013 issue of The FASEB Journal, helps explain why DHA is important in reducing inflammation, and provides an important lead to finding new drugs that will help bring people back to optimal health.

2 Jul 2013

Study shows "bioadhesive" coating can increase intestinal uptake of protein-based drugs

For protein-based drugs such as insulin to be taken orally rather than injected, bioengineers need to find a way to shuttle them safely through the stomach to the small intestine where they can be absorbed and distributed by the bloodstream.

28 Jun 2013

Study suggests amylin deposits are a new biomarker for age-related dementia and Alzheimer's

A second amyloid may play a role in Alzheimer's disease, UC Davis researchers find. A protein secreted with insulin travels through the bloodstream and accumulates in the brains of individuals with type 2 diabetes and dementia, in the same manner as the amyloid beta (Αβ) plaques that are associated with Alzheimer's disease, a study by researchers with the UC Davis Alzheimer's Disease Center has found.

28 Jun 2013

FX006 demonstrates pain relief in Phase 2b osteoarthritis study, Flexion reports

Flexion Therapeutics, Inc., today reported that its lead compound FX006, a novel intra-articular, sustained release steroid, demonstrated pain relief that is of both greater magnitude and longer duration than the most commonly prescribed immediate release steroid, triamcinolone acetonide, in a Phase 2b dose-ranging trial in osteoarthritis.

27 Jun 2013

Anesthesia & Analgesia journal of IARS achieves another increase in its "Impact Factor"

The International Anesthesia Research Society (IARS) is pleased to announce that Anesthesia & Analgesia, official journal of the IARS, has achieved yet another increase in its "Impact Factor"—a key indicator of the influence and scientific value of medical journals.

26 Jun 2013

Researchers say hCNT1 protein may affect cancer cells physiology, apart from transport function

The protein hCNT1, which plays a major role in nucleoside transport, may have other biological functions that may affect cancer cells physiology, apart from their transport function. This is the main conclusion of the new scientific work published on the journal Cell Death and Disease.

26 Jun 2013

Controlled drug release using novel excipients: an interview with Dr Laura Waters, University of Huddersfield

When you take a medicine you may want the drug to all be released immediately or perhaps more slowly over a longer period of time. If we can make a medicine where we control the release then we can tailor our medicines to release at the exact rate we choose that is best for the patient.

26 Jun 2013

Residents in anesthesiology training programs have high rates of burnout and depression

Residents in anesthesiology training programs have high rates of burnout and depression, reports a survey study in the July issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society (IARS).

21 Jun 2013

CRS partners with Bayer HealthCare in clinical drug development

CRS has entered into a long-term strategic partnership with Bayer HealthCare in clinical drug development. Cooperation will include R&D services for early clinical trials (Phases I-IIa).

20 Jun 2013

Chemical hormone released due to stress can trigger mechanism for late onset of Alzheimer's disease

A chemical hormone released in the body as a reaction to stress could be a key trigger of the mechanism for the late onset of Alzheimer's disease, according to a study by researchers at Temple University.

20 Jun 2013

MCL-1 protein is vital for normal heart function, shows study

A study by researchers at Skaggs School of Pharmacy and Pharmaceutical Sciences and the Department of Pharmacology at the University of California, San Diego, shows that a protein called MCL-1, which promotes cell survival, is essential for normal heart function.

18 Jun 2013

Pyrvinium pamoate inhibits drug-resistant prostate cancer

A new drug called pyrvinium pamoate inhibits aggressive forms of prostate cancer that are resistant to standard drugs, according to a study conducted in an animal model. The results will be presented Monday at The Endocrine Society's 95th Annual Meeting in San Francisco.

18 Jun 2013

Bazedoxifene used for treating osteoporosis stops growth of breast cancer cells

A drug approved in Europe to treat osteoporosis has now been shown to stop the growth of breast cancer cells, even in cancers that have become resistant to current targeted therapies, according to a Duke Cancer Institute study.

17 Jun 2013

Pharmacology News and Research

Latest Pharmacology News and Research

Research finding may offer novel path for cancer drug design

p53 restoration of function drug candidate: an interview with Dr. Wayne Danter, MD, FRCPC President and CEO of Critical Outcome Technologies

Study shows activated blood platelets enable cancer cells to penetrate blood vessels

CTI announces publication of preclinical, clinical data for pacritinib in Drugs of the Future 2013

NIDA grants $3.3M to design vaccine conferring immunity to nicotine

Salsalate lowers blood glucose and improves glycemic control in T2D, say scientists

UCLA researchers introduce gene therapy technique to treat sickle cell disease

Research shows DHA found in fish oil can reduce inflammation

Study shows "bioadhesive" coating can increase intestinal uptake of protein-based drugs

Study suggests amylin deposits are a new biomarker for age-related dementia and Alzheimer's

FX006 demonstrates pain relief in Phase 2b osteoarthritis study, Flexion reports

Anesthesia & Analgesia journal of IARS achieves another increase in its "Impact Factor"

Researchers say hCNT1 protein may affect cancer cells physiology, apart from transport function

Controlled drug release using novel excipients: an interview with Dr Laura Waters, University of Huddersfield

Residents in anesthesiology training programs have high rates of burnout and depression

CRS partners with Bayer HealthCare in clinical drug development

Chemical hormone released due to stress can trigger mechanism for late onset of Alzheimer's disease

MCL-1 protein is vital for normal heart function, shows study

Pyrvinium pamoate inhibits drug-resistant prostate cancer

Bazedoxifene used for treating osteoporosis stops growth of breast cancer cells

Industry Focus - Biopharma eBook

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

Pharmacology News and Research

Latest Pharmacology News and Research

Industry Focus - Biopharma eBook

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

Newsletters you may be interested in