Pharmacology News and Research

Latest Pharmacology News and Research

Chemical compounds in coffee beans may help lighten the effects of morning nicotine cravings

For some smokers, the first cigarette of the day is just not as satisfying without a cup of coffee. That could be more than just a morning habit: Chemical compounds in roasted coffee beans may help lighten the effects of morning nicotine cravings, University of Florida researchers have found.

17 Aug 2022

UC San Diego receives $1.3 million grant to understand the role of misfolded tau proteins in dementia

Researchers at the University of California San Diego have received a $1.3 million grant from the W. M. Keck Foundation for a project that could help scientists better understand the role misfolded tau proteins play in causing neurodegenerative diseases like dementia, which may lead to more effective drug therapies.

16 Aug 2022

Non-invasive biomarker could aid with earlier diagnosis of breast cancer metastasis

One woman is diagnosed with breast cancer every fourteen seconds somewhere across the globe -; based on data showing that an approximate 2.3 million women worldwide were newly diagnosed with breast cancer in 2020.

16 Aug 2022

Scientists create a mathematical model to predict genetic resistance to antimalarial drugs

Researchers have created a mathematical model to predict genetic resistance to antimalarial drugs in Africa to manage one of the biggest threats to global malarial control.

12 Aug 2022

Study defines how the circadian clock influences cell growth, metabolism and tumor progression

In a new University of California, Irvine-led study, researchers define how the circadian clock influences cell growth, metabolism and tumor progression.

11 Aug 2022

PET imaging could help measure the pharmacodynamic effects of using STING-activating drugs

Stimulator of interferon genes, or STING, helps regulate immune activation. Thus, drugs that activate STING are being tested as a form of cancer immunotherapy and for treating certain infections.

11 Aug 2022

New computation-guided approach to identify small molecule corrector drugs for p53 hotspot mutations

A new study, led by researchers from the University of California, Irvine and the University of California, San Diego, reveals a new computation-guided approach to identify small molecules that can restore aspects of wild-type p53 tumor suppression function to mutated p53, which play an important role in many human cancers.

11 Aug 2022

EPA action boosts grassroots momentum to reduce toxic ‘forever chemicals’

The intake pumps that once drew 6 million gallons of water a day from the Oostanaula River now sit mostly dormant in this northwestern Georgia city.

10 Aug 2022

Neuronal cilia are important for dopamine receptor 1 signaling, study shows

A historically overlooked rod-like projection present on nearly every cell type in the human body may finally be getting its scientific due: A new study has found that these appendages, called cilia, on neurons in the brain have a key role in ensuring a specific dopamine receptor's signals are properly received.

9 Aug 2022

Researchers unravel a novel molecular target of eicosapentaenoic acid

Eicosapentaenoic acid (EPA) is an essential nutrient belonging to the omega-3 group of polyunsaturated fatty acids (PUFAs). As the human body cannot synthesize PUFAs, dietary supplements containing EPA are required for normal physiological functions. Found abundantly in natural sources like fish, hemp oil, and linseed oil, EPA is known to exhibit anti-inflammatory, neuroprotective, and cardiovascular protective activities.

9 Aug 2022

Researchers develop a long-acting injectable formulation of the anti-TB drug rifabutin

In 2020, more than 1.5 million people around the world died of tuberculosis, marking the first time in more than a decade that annual TB deaths had increased and demonstrating the global need for better access to treatments.

8 Aug 2022

Should pregnant women be included clinical trials?

The current study reports some of the scientific, ethical, and legal considerations that will support the inclusion of pregnant women in future research.

8 Aug 2022

Extracellular vesicle-based surface protein assay likely to lead to a better way to detect early-stage hepatocellular carcinoma

Primary liver cancer, the third-leading cause of cancer-related death worldwide, takes more than 30,000 lives in the United States each year. The high mortality rates can be attributed in part to the fact that a significant portion of the patients are detected at a late stage, when potentially curative treatments are no longer an option. Unfortunately, today's screening methods are not able to routinely provide accurate, early detection.

5 Aug 2022

Turning to Organ-on-a-Chip Studies for the Future of Drug Discovery

In this interview, we speak to Tom Kostrzewski, VP of Science and Technology at CN Bio, about their organ-on-a-chip product and the future of drug discovery.

From CN-Bio 3 Aug 2022

NUS study provides evidence of the cytotoxic effect of black cardamom on lung cancer cells

The main challenges associated with existing lung cancer drugs are severe side effects and drug resistance. There is hence a constant need to explore new molecules for improving the survival rate and quality of life of lung cancer patients.

1 Aug 2022

Two Weill Cornell doctoral students receive Gilliam Fellowships for Advanced Study from HHMI

Two doctoral students at Weill Cornell Graduate School of Medical Sciences have been awarded prestigious Gilliam Fellowships for Advanced Study from the Howard Hughes Medical Institute.

29 Jul 2022

Study highlights impaired ketogenesis as a potential confounder of severe COVID-19

In severe Covid-19 patients, the metabolism produces insufficient amounts of certain energy-rich compounds called ketone bodies. However, these energy carriers are needed by two important cell types in the immune system in order to fight the virus effectively.

28 Jul 2022

Lactating mice expose their feeding pups to triclosan resulting in early signs of liver damage

In mouse studies, researchers at University of California San Diego School of Medicine report that lactating mothers expose their feeding pups to triclosan, an antimicrobial commonly used in consumer products, resulting in early signs of liver damage that can eventually lead to more serious impairment and illness, such as nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH).

28 Jul 2022

Genetic variations in one serotonin receptor could be the reason behind psychedelic treatment disparity

When all else fails, some patients trying to overcome alcoholism, severe depression or anxiety, and even cluster headaches, turn to psychedelic drugs, which clinical research has shown can help treat individuals with these conditions, sometimes with dramatically positive results.

27 Jul 2022

Researchers unravel how one gut bacterium influences immunity

From immunity to metabolism to mental health, it seems like the gut microbiome has been linked to every aspect of human health and disease.

27 Jul 2022

Pharmacology News and Research

Latest Pharmacology News and Research

Chemical compounds in coffee beans may help lighten the effects of morning nicotine cravings

UC San Diego receives $1.3 million grant to understand the role of misfolded tau proteins in dementia

Non-invasive biomarker could aid with earlier diagnosis of breast cancer metastasis

Scientists create a mathematical model to predict genetic resistance to antimalarial drugs

Study defines how the circadian clock influences cell growth, metabolism and tumor progression

PET imaging could help measure the pharmacodynamic effects of using STING-activating drugs

New computation-guided approach to identify small molecule corrector drugs for p53 hotspot mutations

EPA action boosts grassroots momentum to reduce toxic ‘forever chemicals’

Neuronal cilia are important for dopamine receptor 1 signaling, study shows

Researchers unravel a novel molecular target of eicosapentaenoic acid

Researchers develop a long-acting injectable formulation of the anti-TB drug rifabutin

Should pregnant women be included clinical trials?

Extracellular vesicle-based surface protein assay likely to lead to a better way to detect early-stage hepatocellular carcinoma

Turning to Organ-on-a-Chip Studies for the Future of Drug Discovery

NUS study provides evidence of the cytotoxic effect of black cardamom on lung cancer cells

Two Weill Cornell doctoral students receive Gilliam Fellowships for Advanced Study from HHMI

Study highlights impaired ketogenesis as a potential confounder of severe COVID-19

Lactating mice expose their feeding pups to triclosan resulting in early signs of liver damage

Genetic variations in one serotonin receptor could be the reason behind psychedelic treatment disparity

Researchers unravel how one gut bacterium influences immunity

Pittcon Highlights: Pharmaceutical & Biologic eBook

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

Pharmacology News and Research

Latest Pharmacology News and Research

Pittcon Highlights: Pharmaceutical & Biologic eBook

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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