Pharmacology News and Research

Latest Pharmacology News and Research

UCI-led study identifies sex-specific circuits of muscle signaling to other tissues

A new University of California, Irvine-led study identifies sex-specific circuits of muscle signaling to other tissues and that the organs and processes muscle impacts are markedly different between males and females.

31 May 2022

UCLA researchers identify a method to make tumors susceptible to immune attack

One powerful way cancer cells defend against tumor-killing immune cells is to load up their cell surface with a protein known as PD-L1. Now a team of UCLA Jonsson Comprehensive Cancer Center researchers led by Roger S. Lo, MD, PhD, has identified a method to degrade tumor cell-surface PD-L1, thereby making tumors susceptible to immune attack.

31 May 2022

Discovery explains why patients with severe asthma are unresponsive to treatment

Patients with the most severe form of asthma produce special substances in their airways when taking medicine during an asthma attack that block the treatment from working, according to a study where Rutgers scientists collaborated with researchers at Genentech, a member of the Roche Group.

30 May 2022

Gut bacteria can reduce the effectiveness of certain blood pressure drugs

A new study from The University of Toledo College of Medicine and Life Sciences has shown gut bacteria can reduce the effectiveness of certain blood pressure drugs.

26 May 2022

A sugar-studded protein could be key to stopping Alzheimer’s disease progression, finds study

In a bit of "reverse engineering" research using brain tissues from five people who died with Alzheimer's disease, Johns Hopkins Medicine researchers say they discovered that a special sugar molecule could play a key role in the development of Alzheimer's disease.

25 May 2022

Study identifies a gene that plays an important role in embryo development

A new study co-led by a Cedars-Sinai investigator identified a gene that plays an important role in a biological pathway involved in embryo development.

24 May 2022

Antidiabetic medication may also decrease blood vessel dysfunction associated with aging

An FDA-approved drug to lower blood sugar in adults with Type 2 diabetes also may decrease blood vessel dysfunction associated with aging, according to a new study from the University of Missouri School of Medicine.

24 May 2022

Montefiore Einstein Cancer Center partners with the Price Family Foundation to advance cancer equity

The National Cancer Institute-designated Montefiore Einstein Cancer Center (MECC) has partnered with the Price Family Foundation to fund eight research teams developing novel cancer therapies and improving cancer outcomes for historically marginalized communities in the Bronx.

20 May 2022

Novel brain-permeable Cdk5 inhibitor alters neurobehavior in mice

James Bibb, Ph.D., and colleagues have described a novel preclinical drug that could have the potential to combat depression, brain injury and diseases that impair cognition. The drug, which notably is brain-permeable, acts to inhibit the kinase enzyme Cdk5.

20 May 2022

Researchers discover potential treatment approach for advanced uveal melanoma

An international team of researchers led by University College Dublin (UCD) have uncovered a potential treatment approach for advanced uveal melanoma (UM), a type of cancer that effects the eye.

19 May 2022

Molecular pathway allows cells to sense when their lipid supplies become depleted

UT Southwestern researchers have discovered a molecular pathway that allows cells to sense when their lipid supplies become depleted, prompting a flurry of activity that prevents starvation.

18 May 2022

New tool can accurately predict which hospitalized patients need critical care for COVID-19

Scientists have developed and validated an algorithm that can help healthcare professionals identify who is most at risk of dying from COVID-19 when admitted to a hospital, reports a study published today in eLife.

17 May 2022

Targeting specific neurons modulates memory retrieval and alters anxiety-like behaviors in mice

We humans lose mental acuity, an unfortunate side effect of aging. And for individuals with neurodegenerative conditions such as Alzheimer's and Parkinson's, the loss of cognitive function often accompanied by mood disorders such as anxiety is a harrowing experience.

16 May 2022

Rutgers study identifies key protein for brain stem cell longevity

A receptor that was first identified as necessary for insulin action, that also is located on the neural stem cells found deep in the brains of mice, is pivotal for brain stem cell longevity, according to a Rutgers study, a finding that has important implications for brain health and future therapies for brain disorders.

11 May 2022

How new Insights into ESR1 Mutant Breast Cancers may lead to Novel Therapy Targets

In this interview, we speak to Steffi Oesterreich, PH.D., from the University of Pittsburgh, about how new insights into a gene mutation present in 20-30% of breast cancer recurrences may have a silver lining, leading to novel treatment opportunities.

9 May 2022

Antigen-presenting cancer-associated fibroblasts offer a new target to fight pancreatic cancer

Scar-like cells that make up a sizable portion of malignant pancreatic tumors and shield these cancers from immune attack are derived from mesothelial cells that line tissues and organs, a new study led by UT Southwestern researchers suggests.

6 May 2022

Study assesses the efficacy and safety of lithium treatment in patients infected with severe SARS-CoV-2

Researchers assessed the efficacy and safety of using lithium for coronavirus disease 2019 (COVID-19) treatment.

5 May 2022

Discovery could lead to new treatments to minimize cravings in people with addictions

For some people with alcohol use disorder, it might be the sight of a familiar bar or a favorite bottle; for others, it might be the feeling of leaving the office after a stressful day at work or stepping into a crowded party. Most people who struggle with drug or alcohol addiction have particular cues that set off their cravings.

4 May 2022

Study finds brain circuit controlling drug withdrawal-induced anxiety and reinstatement

New research from the University of California, Irvine, finds that drug withdrawal-induced anxiety and reinstatement of drug seeking behaviors are controlled by a single pathway in the brain and centered around dopamine cells.

4 May 2022

Scientists discover a potential new method of active immunization to prevent Alzheimer's disease

During experiments in animal models, researchers at the University of Kansas have discovered a possible new approach to immunization against Alzheimer's disease (AD).

4 May 2022

Pharmacology News and Research

Latest Pharmacology News and Research

UCI-led study identifies sex-specific circuits of muscle signaling to other tissues

UCLA researchers identify a method to make tumors susceptible to immune attack

Discovery explains why patients with severe asthma are unresponsive to treatment

Gut bacteria can reduce the effectiveness of certain blood pressure drugs

A sugar-studded protein could be key to stopping Alzheimer’s disease progression, finds study

Study identifies a gene that plays an important role in embryo development

Antidiabetic medication may also decrease blood vessel dysfunction associated with aging

Montefiore Einstein Cancer Center partners with the Price Family Foundation to advance cancer equity

Novel brain-permeable Cdk5 inhibitor alters neurobehavior in mice

Researchers discover potential treatment approach for advanced uveal melanoma

Molecular pathway allows cells to sense when their lipid supplies become depleted

New tool can accurately predict which hospitalized patients need critical care for COVID-19

Targeting specific neurons modulates memory retrieval and alters anxiety-like behaviors in mice

Rutgers study identifies key protein for brain stem cell longevity

How new Insights into ESR1 Mutant Breast Cancers may lead to Novel Therapy Targets

Antigen-presenting cancer-associated fibroblasts offer a new target to fight pancreatic cancer

Study assesses the efficacy and safety of lithium treatment in patients infected with severe SARS-CoV-2

Discovery could lead to new treatments to minimize cravings in people with addictions

Study finds brain circuit controlling drug withdrawal-induced anxiety and reinstatement

Scientists discover a potential new method of active immunization to prevent Alzheimer's disease

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Pharmacology News and Research

Latest Pharmacology News and Research

Pittcon Highlights: Pharmaceutical & Biologic eBook

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Automating research - solutions and best practices

How can microdialysis benefit drug development

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