Pharmacology News and Research

Latest Pharmacology News and Research

Discovery of family of genes linked to the development of liver cancer

An interdisciplinary team of researchers at Stony Brook University Medical Center has identified a family of genes linked to the development of liver cancer.

28 Feb 2008

Diltiazem reduces cocaine cravings in a rat model

Researchers from Boston University School of Medicine and Harvard Medical School have found that diltiazem, a drug used in the treatment of high blood pressure, reduces cocaine cravings in a rat model.

28 Feb 2008

Hormones produced by the heart eliminate pancreatic cancer in mice

Hormones produced by the heart eliminated human pancreatic cancer in more than three-quarters of the mice treated with the hormones and eliminated human breast cancer in two-thirds of the mice, according to researcher David Vesely, a doctor at the James A. Haley Veterans Hospital in Tampa and a professor at the University of South Florida (USF).

27 Feb 2008

Risks of CVD for COX-2 inhibitors lower than previously reported

In an article published in the March issue of the Journal of Cardiovascular Pharmacology and Therapeutics, researchers from Florida Atlantic University (FAU) assess the totality of evidence, including strengths and limitations of different types of evidence contributing to the debate about cardiovascular disease (CVD) risks of cyclooxygenase-2 (COX-2) inhibitors and non-steroidal anti-inflammatory drugs (NSAIDs).

27 Feb 2008

Adult-onset obesity seen in mice when gene ubiquitin disrupted

Texas and California scientists who disrupted one type of the gene ubiquitin (Ubb) in mice observed neuronal death in the hypothalamus, impaired control of energy balance and adult-onset obesity in the rodents.

27 Feb 2008

Many stroke, heart attack patients may not benefit from aspirin

Up to 20 percent of patients taking aspirin to lower the risk of suffering a second cerebrovascular event do not have an antiplatelet response from aspirin, the effect thought to produce the protective effect, researchers at the University at Buffalo have shown.

26 Feb 2008

ImClone Systems enrols first patient in clinical trial of IMC-1121B to treat liver cancer

ImClone Systems Incorporated has announced that it has enrolled the first patient in a disease-directed Phase II clinical trial of IMC-1121B to treat patients with advanced hepatocellular carcinoma (liver cancer).

26 Feb 2008

Hair loss breakthrough

A healthy individual loses around a hundred hairs a day. Nothing to worry about as long as they are constantly replaced and the losses occur evenly around the whole scalp.

26 Feb 2008

Lead exposure may lead to adult-onset obesity in men

Scientists know exposure to low levels of lead can result in learning disabilities, hearing loss, language impairments and vision loss, but a newly discovered side effect may be adult-onset obesity in men, according to a University of Houston professor.

21 Feb 2008

Discovery of gene expression pathway that influences process of oxidative stress

The same chemical reaction that causes iron to rust plays a similarly corrosive role in our bodies.

21 Feb 2008

Scientists shed light on long-distance signaling in developing neurons

A longstanding puzzle in neurodevelopment may have yielded up a key secret.

20 Feb 2008

New key finding in neurodevelopment

A longstanding puzzle in neurodevelopment may have yielded up a key secret. A team led by scientists at Weill Cornell Medical College says they have determined how events at the very tips of the developing neuron's long, skinny axon affect gene transcription back in the cell's distant nucleus.

20 Feb 2008

Discovery of 'overdrive' protein could broaden drug design options

New research by scientists at the University of North Carolina at Chapel Hill shows for the first time that an important family of proteins known to function at the cell surface also functions at a site within the cell.

13 Feb 2008

Moss protein plays role in Alzheimer's disease

Preventing Alzheimer's from developing is a goal of Raphael Kopan, Ph.D., professor of molecular biology and pharmacology at the Washington University School of Medicine.

11 Feb 2008

Scientists reveal a new target to fight bad cholesterol

Scientists have uncovered a new region in the genome that is responsible for the body's ability to regulate bad cholesterol which is linked to heart attack and stroke.

8 Feb 2008

RNA-associated introns guide nerve-cell channel production

Researchers at the University of Pennsylvania School of Medicine have discovered that introns, or junk DNA to some, associated with RNA are an important molecular guide to making nerve-cell electrical channels.

7 Feb 2008

New cancer center at NewYork-Presbyterian/Weill Cornell

NewYork-Presbyterian Hospital/Weill Cornell Medical Center has created an expanded cancer program dedicated to advancing research, prevention and treatment of the disease. The new Cancer Center is led by renowned cancer physician-scientist Dr. Andrew Dannenberg.

5 Feb 2008

Targeting astrocytes slows progression of Lou Gehrig's disease

In what the researchers say could be promising news in the quest to find a therapy to slow the progression of amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s disease, scientists at the University of California, San Diego (UCSD) School of Medicine have shown that targeting neuronal support cells called astrocytes sharply slows disease progression in mice.

4 Feb 2008

Enzyme released by mast cells in the lungs could be a new target for asthma

An enzyme released by mast cells in the lungs appears to play a key role in the tightening of airways that is a hallmark of asthma pointing to a potential new target for treatment against the illness.

4 Feb 2008

Potential cause of age differences in stimulant response identified

In young children, psychostimulants relieve symptoms of Attention Deficit Disorder, yet in adolescents and adults, those same medications can cause euphoria and are often abused.

31 Jan 2008