Pharmacology News and Research

Latest Pharmacology News and Research

Study shows anti-itch and pain relief potential of protein in tick saliva

A protein found in tick saliva could be turned into a drug that eases itching and chronic pain in people.

8 Mar 2022

Study reveals the potential of novel antiviral drug combinations to stop COVID-19 spread

Researchers from Columbia Engineering, Fiocruz's Center for Technological Development in Health and the Oswaldo Cruz Institute in Brazil, Memorial Sloan Kettering Cancer Center, and Rockefeller University recently reported that, by combining inhibitors of polymerases and exonucleases--enzymes that allow SARS-CoV-2 to reproduce--they were able to reduce SARS-CoV-2 replication 10 times more than when using just the polymerase inhibitors.

7 Mar 2022

Researchers discover functional links between potassium channel gene variants and neonatal epilepsy

Northwestern Medicine scientists have discovered functional links between dozens of potassium channel gene variants and neonatal epilepsy, according to a study published in JCI Insight.

4 Mar 2022

High-fat diet combined with liquid fructose intake accelerates fat accumulation in the liver

A high-fat diet is not enough to cause short-term fatty liver disease. However, if this diet is combined with the intake of beverages sweetened with liquid fructose, the accumulation of fats in the liver accelerates and hypertriglyceridemia —a cardiovascular risk factor— can appear.

4 Mar 2022

Discovery could open new doors in the field of blood pressure research

The research group of internal medicine at the University of Oulu, Finland, has discovered a previously unknown blood pressure-regulating circuit.

4 Mar 2022

Study shows the viability of lung transplants in patients with COVID-19-associated ARDS

Patients with COVID-19-associated acute respiratory distress syndrome who received lung transplants had similar outcomes, compared to transplant patients without COVID-19, according to a Northwestern Medicine study published in JAMA.

2 Mar 2022

Peer-led online communities effective in increasing HIV self-testing among MSM of color

A new University of California, Irvine-led study, called the HOPE (Harnessing Online Peer Education) HIV study, revealed that using peer-led online communities was successful in increasing HIV self-testing and reducing alcohol consumption among Latinx and African American MSM (men who have sex with men).

28 Feb 2022

Scientists uncover new role of chromatin-modulatory enzyme during cancer development

Researchers at the University of North Carolina at Chapel Hill and the UNC Lineberger Comprehensive Cancer Center have uncovered a new role of a chromatin-modulatory enzyme, termed EZH2, during cancer development.

24 Feb 2022

Discovery of signaling pathway in immune cells may lead to new therapeutic approach for autoimmune diseases

Autoimmune diseases are triggered when the immune system malfunctions and attacks the body's own structures.

23 Feb 2022

Codiak's publication highlights the ability of exoASO-STAT6 to selectively target tumor-associated macrophages

Codiak BioSciences, Inc., a clinical-stage biopharmaceutical company pioneering the development of exosome-based therapeutics as a new class of medicines, today announced the online publication of a new manuscript, Exosome mediated genetic reprogramming of tumor associated macrophages by exoASO-STAT6 leads to potent monotherapy anti-tumor efficacy, in the American Association for the Advancement of Science's journal, Science Advances.

18 Feb 2022

Inside the tactical tug of war over the controversial Alzheimer’s drug

The drug industry, patient advocates, and congressional Republicans have all attacked federal officials' decision to decline routine Medicare coverage for a controversial Alzheimer's drug.

16 Feb 2022

Human nose organoids provide better understanding of the first steps toward SARS-CoV-2 infection

Preclinical models that recapitulate aspects of human airway disease are essential for the advancement of novel therapeutics and vaccines.

16 Feb 2022

Phase one study of oral SARS-CoV-2 antiviral agent nirmatrelvir

A recent study posted to the medRxiv* preprint server reported the phase one pharmacokinetic and safety data of nirmatrelvir/ritonavir to facilitate its rapid progression to the last stages of clinical trials in coronavirus disease 2019 (COVID-19) patients with mild to moderate disease.

14 Feb 2022

Challenges in safely deprescribing common anticholinergic drugs

Medications with anticholinergic properties have been consistently associated with a wide range of adverse outcomes for older adults including cognitive impairment, yet these drugs continue to be commonly prescribed for depression, urinary incontinence, irritable bowel syndrome and Parkinson's disease.

11 Feb 2022

Biological events occurring during puberty trigger sex differences in learning and memory

New research from the University of California, Irvine reveals that sex differences in learning and memory mechanisms are triggered by biological events occurring during puberty.

10 Feb 2022

Researchers reveal new therapeutic way to block oncogenic RAS mutants

As a 10-year journey comes to fruition, MUSC Hollings Cancer Center researcher John O'Bryan, Ph.D., and colleagues have demonstrated a new therapeutic way to block a protein that is frequently mutated in cancers.

9 Feb 2022

UCI case report: Antihistamines may provide relief for people suffering from long COVID-19 symptoms

Antihistamines may provide relief for the millions of people suffering from the painful, debilitating symptoms of long COVID-19 that impair daily functioning.

9 Feb 2022

Prevalence of genetic susceptibility to cardiac arrhythmia may be underestimated, study says

By sequencing known genes associated with cardiac arrhythmia risk in more than 20,000 people without an indication for genetic testing, scientists were able to identify pathogenic and likely pathogenic variants in nearly one percent of individuals, according to a study published in Circulation.

9 Feb 2022

Paracetamol use increases blood pressure, study shows

Long-term paracetamol use could increase the risk of heart disease and strokes in people with high blood pressure, a study suggests.

7 Feb 2022

Colchicine holds promise to reduce the risk of severe COVID-19

A recent article, published in Rheumatology and Therapy, reviews the potent evidence of colchicine against the SARS-CoV-2 infection.

7 Feb 2022

Pharmacology News and Research

Latest Pharmacology News and Research

Study shows anti-itch and pain relief potential of protein in tick saliva

Study reveals the potential of novel antiviral drug combinations to stop COVID-19 spread

Researchers discover functional links between potassium channel gene variants and neonatal epilepsy

High-fat diet combined with liquid fructose intake accelerates fat accumulation in the liver

Discovery could open new doors in the field of blood pressure research

Study shows the viability of lung transplants in patients with COVID-19-associated ARDS

Peer-led online communities effective in increasing HIV self-testing among MSM of color

Scientists uncover new role of chromatin-modulatory enzyme during cancer development

Discovery of signaling pathway in immune cells may lead to new therapeutic approach for autoimmune diseases

Codiak's publication highlights the ability of exoASO-STAT6 to selectively target tumor-associated macrophages

Inside the tactical tug of war over the controversial Alzheimer’s drug

Human nose organoids provide better understanding of the first steps toward SARS-CoV-2 infection

Phase one study of oral SARS-CoV-2 antiviral agent nirmatrelvir

Challenges in safely deprescribing common anticholinergic drugs

Biological events occurring during puberty trigger sex differences in learning and memory

Researchers reveal new therapeutic way to block oncogenic RAS mutants

UCI case report: Antihistamines may provide relief for people suffering from long COVID-19 symptoms

Prevalence of genetic susceptibility to cardiac arrhythmia may be underestimated, study says

Paracetamol use increases blood pressure, study shows

Colchicine holds promise to reduce the risk of severe COVID-19

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Pharmacology News and Research

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How can microdialysis benefit drug development

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