Scleroderma News and Research

Latest Scleroderma News and Research

Patients with scleroderma have reduced levels of Cathepsin L

Much of the research on scleroderma, a connective tissue disease that causes scarring, or fibrosis, has focused on the increased number of proteins promoting fibrosis in these patients. A Medical University of South Carolina (MUSC) research team took a different tact and measured the levels of an antifibrotic protein, Cathepsin L, in these patients.

30 Sep 2022

Study identifies mechanism behind 'cytokine storm' in COVID-19 patient lungs

A new study by HSS Research Institute scientists identifies a mechanism by which SARS-CoV-2 induces the inflammatory response in COVID-19 patient lungs, so-called "cytokine storm", that can lead to lasting tissue damage and poor patient outcomes.

13 Sep 2022

Chemokine-DNA nanoparticles can induce chronic, dysfunctional immune responses

Small proteins, called chemokines, that direct immune cells toward sites of infection can also form DNA-bound nanoparticles that can induce chronic, dysfunctional immune responses, according to a new study by researchers at Weill Cornell Medicine and Hospital for Special Surgery (HSS).

15 Jul 2022

Elevated and sustained autoantibodies following COVID-19

A new study demonstrated that autoantibody levels rise following acute SARS-CoV-2 infection and remain to be elevated for about six months.

10 May 2022

Urgent action needed to address disparities in women’s heart health

Investing in and improving research, awareness and equity in women's heart health are critical for the health and well-being of women, according to a new Presidential Advisory from the American Heart Association, published today in the Association's flagship journal Circulation.

9 May 2022

A critical subset of fibroblasts may lie at the origins of rare autoimmune disease

Supporting actors sometimes steal the show. In a new study published today in Cell, researchers headed by Prof. Ido Amit at the Weizmann Institute of Science have shown that supporting cells called fibroblasts, long viewed as uniform background players, are in fact extremely varied and vital.

5 Apr 2022

Biodegradable nanoparticle used in medical sutures could help combat scleroderma

Investigators have discovered that a biodegradable nanoparticle used in medical sutures could combat a rare, sometimes-fatal autoimmune disease.

7 Mar 2022

Gene key to excessive cell proliferation could be a potential target for fatal pulmonary hypertension

A gene that is overexpressed in some aggressive cancers also appears to be key to the excessive cell proliferation that thickens the walls of pulmonary arteries and ultimately causes the right ventricle of the heart to fail, scientists report.

16 Dec 2021

Black patients with systemic sclerosis may experience poorer outcomes more often than others

New research presented this week at ACR Convergence, the American College of Rheumatology's annual meeting, shows that Black people living with systemic sclerosis may have more severe disease and worse prognosis than patients in other racial or ethnic groups, and these worrying disparities may be driven by several socioeconomic factors.

2 Nov 2021

Platelet inhibitors may be linked with reduction in digital ulcers in people with systemic sclerosis

New research presented this week at ACR Convergence, the American College of Rheumatology's annual meeting, shows that use of platelet inhibitors could be associated with a reduction in the occurrence of digital ulcers, painful sores on the extremities that can progress to gangrene, in people with systemic sclerosis.

1 Nov 2021

NIH begins clinical trial to assess extra COVID-19 vaccine dose in people with autoimmune disease

The National Institutes of Health has begun a clinical trial to assess the antibody response to an extra dose of an authorized or approved COVID-19 vaccine in people with autoimmune disease who did not respond to an original COVID-19 vaccine regimen.

27 Aug 2021

Researchers discover potential biomarker for lung disease in scleroderma patients

Researchers have discovered a protein that may predict disease severity for a lung condition that often proves fatal to patients with scleroderma.

3 Aug 2021

Online mental health intervention improves anxiety in isolated scleroderma patients during the pandemic

People with a rare autoimmune disease, who likely experience more serious isolation during a global pandemic, saw their anxiety and depression improve after receiving online mental health intervention through an international study involving investigators from Michigan Medicine.

16 Jun 2021

Algorithm accurately identifies pulmonary arterial hypertension in patients with scleroderma

Screening for a sometimes fatal condition among patients with a rare autoimmune disease could soon - thanks to a computer algorithm - become even more accurate.

21 Apr 2021

Repurposing an anti-inflammatory drug can prevent lung disease in patients with systemic sclerosis

Research led by Michigan Medicine's Scleroderma Program and published in Arthritis & Rheumatology found that tocilizumab, a FDA-approved anti-inflammatory drug used to combat rheumatoid arthritis, can prevent lung disease in patients with systemic sclerosis if detected early enough in the disease course.

31 Mar 2021

New approach can help treat hypertrophic cardiomyopathy with precision medicine

Hypertrophic cardiomyopathy (HCM) is a cardiovascular disease characterized by thickening of the left ventricle, otherwise known as the main squeezing chamber of the heart. HCM is best known for causing sudden death in athletes but can occur in persons of any age, often without symptoms.

26 Feb 2021

A protein may be responsible for triggering lung scarring in scleroderma patients

Systemic sclerosis is an autoimmune disease associated with inflammation and fibrosis, or scarring, that affects organs including the skin, heart, kidney and lungs.

17 Dec 2020

Research provides deeper insight into the pathogenesis of sclerodermatous chronic GVHD

Occasionally, following a transplant procedure, the donor's immune cells recognize the recipient's tissues as foreign and trigger a multisystem disorder called graft-versus-host disease (GVHD).

2 Dec 2020

LOX plays a number of key roles in promoting skin and organ fibrosis in scleroderma

A team of researchers at the Medical University of South Carolina (MUSC) has found that the molecule lysyl oxidase (LOX) plays a number of important roles in promoting skin and organ fibrosis in scleroderma, a connective tissue disorder.

17 Nov 2020

Women with interstitial lung disease may not need to terminate their pregnancies

A new study shows that women with interstitial lung disease (ILD) related to autoimmune disease may not need to terminate their pregnancies--despite the increased risk of adverse outcomes--provided they have close monitoring from their team of multidisciplinary physicians before, during and after pregnancy.

6 Nov 2020

Scleroderma News and Research

Latest Scleroderma News and Research

Patients with scleroderma have reduced levels of Cathepsin L

Study identifies mechanism behind 'cytokine storm' in COVID-19 patient lungs

Chemokine-DNA nanoparticles can induce chronic, dysfunctional immune responses

Elevated and sustained autoantibodies following COVID-19

Urgent action needed to address disparities in women’s heart health

A critical subset of fibroblasts may lie at the origins of rare autoimmune disease

Biodegradable nanoparticle used in medical sutures could help combat scleroderma

Gene key to excessive cell proliferation could be a potential target for fatal pulmonary hypertension

Black patients with systemic sclerosis may experience poorer outcomes more often than others

Platelet inhibitors may be linked with reduction in digital ulcers in people with systemic sclerosis

NIH begins clinical trial to assess extra COVID-19 vaccine dose in people with autoimmune disease

Researchers discover potential biomarker for lung disease in scleroderma patients

Online mental health intervention improves anxiety in isolated scleroderma patients during the pandemic

Algorithm accurately identifies pulmonary arterial hypertension in patients with scleroderma

Repurposing an anti-inflammatory drug can prevent lung disease in patients with systemic sclerosis

New approach can help treat hypertrophic cardiomyopathy with precision medicine

A protein may be responsible for triggering lung scarring in scleroderma patients

Research provides deeper insight into the pathogenesis of sclerodermatous chronic GVHD

LOX plays a number of key roles in promoting skin and organ fibrosis in scleroderma

Women with interstitial lung disease may not need to terminate their pregnancies

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

Scleroderma News and Research

Latest Scleroderma News and Research

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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