Sickle Cell Disease News and Research

Latest Sickle Cell Disease News and Research

Regenacy Pharmaceuticals partners with CMTA to advance ricolinostat for treating hereditary neuropathy

Regenacy Pharmaceuticals, LLC, a clinical-stage biopharmaceutical company developing breakthrough treatments for diabetic and other peripheral neuropathies, today announced a collaboration with the Charcot-Marie-Tooth Association, a registered non-profit organization serving the hereditary neuropathy patient community, to validate the role of HDAC6 in multiple forms of Charcot-Marie-Tooth disease and evaluate the efficacy of ricolinostat, a selective HDAC6 inhibitor, in animal models.

2 Aug 2018

Therapy with L-Glutamine reduces pain in patients with sickle cell disease

UCSF Benioff Children's Hospital Oakland clinical researchers, in conjunction with other sickle cell centers and scientists at Emmaus Life Sciences, Inc., have demonstrated that therapy with L-Glutamine reduced the frequency of pain episodes in both pediatric and adult patients with sickle cell disease.

27 Jul 2018

Researchers identify enzyme as potential new drug target for blood disorders

Medical researchers have identified a key signaling protein that regulates hemoglobin production in red blood cells, offering a possible target for a future innovative drug to treat sickle cell disease.

20 Jul 2018

CRISPR/Cas9 gene editing can cause greater genetic damage than previously thought

Scientists at the Wellcome Sanger Institute have discovered that CRISPR/Cas9 gene editing can cause greater genetic damage in cells than was previously thought. These results create safety implications for gene therapies using CRISPR/Cas9 in the future as the unexpected damage could lead to dangerous changes in some cells.

16 Jul 2018

New guideline recommends first-trimester screening of pregnant women for asymptomatic bacteriuria

First-trimester screening of pregnant women for asymptomatic bacteriuria -- higher than normal bacteria levels without symptoms of a bladder infection -- is recommended by the Canadian Task Force on Preventive Health Care in an updated guideline in CMAJ

9 Jul 2018

Music therapy shows promise for improving lives of people with sickle cell disease

A new study published in the Journal of Music Therapy reveals promising findings for the application of improvisational music therapy in assuaging the multidimensional acute pain of adult patients with sickle cell disease.

14 Jun 2018

Acetaminophen use helps reduce acute kidney injury risk in pediatric heart surgery patients

Children who underwent cardiac surgery were less likely to develop acute kidney injury if they had been treated with acetaminophen in the first 48 hours after their procedures, according to a Vanderbilt study just published in JAMA Pediatrics.

15 May 2018

Study: Stigmatizing language in medical records may play a role in how the patient is treated

A Johns Hopkins study found that physicians who use stigmatizing language in their patients' medical records may affect the care those patients get for years to come.

9 May 2018

Doctors cure sickle cell patients using allogeneic stem cells

Seven adults with sickle cell disease have been cured by doctors at the University of Illinois Hospital, thanks to the development of a new protocol for stem cell transplantation.

25 Apr 2018

Pitt researcher secures nearly $5 million NIH funding for 'Tic-Tac-Toe' RF coil system

The University of Pittsburgh houses a whole-body 7 Tesla magnetic resonance imager (7T MRI), one of the strongest human MRI devices in the world and a powerful imaging tool that allows researchers to gain a far better understanding of brain structure and function.

13 Apr 2018

Using Cord Blood to Alleviate the Symptoms of Autism

Cord blood has been studied extensively for the treatment of hematological diseases such as cancer and sickle cell anemia, but is now in phase II trials for the alleviation of autism. Dr. Ann Smith, director of Smart Cells who provided the cord blood for the trial, discusses the research and it's potential.

9 Apr 2018

Genetic mutation that may protect people from malaria found to be more common

A genetic mutation that may protect people from malaria, but was thought to be rare, is surprisingly common, suggest the findings of a new study led by scientists at The Scripps Research Institute.

23 Mar 2018

University of Illinois at Chicago awarded $4.6 million NIH grant for chronic pain research

The University of Illinois at Chicago has been awarded a $4.6 million grant from the National Heart, Lung, and Blood Institute to study the molecular neurobiology of chronic pain in patients with sickle cell disease and to develop potential new drug treatments.

26 Feb 2018

Study reveals HCT as effective treatment for NHL patients regardless of age

Results from a retrospective study of 1,629 patients with non-Hodgkin lymphoma showed that survival at 4 years following allogeneic hematopoietic cell transplantation for patients age 65 years and older is comparable to patients age 55 to 64 years.

21 Feb 2018

Combination chemotherapy increases survival in animal models of glioblastoma

A diagnosis of the brain cancer glioblastoma carries a dismal prognosis, with most patients dying within five years.

23 Jan 2018

Sangamo and Pfizer partner for development of new zinc finger protein gene therapy to treat ALS

Sangamo Therapeutics, Inc. and Pfizer Inc. today announced a collaboration for the development of a potential gene therapy using zinc finger protein transcription factors (ZFP-TFs) to treat amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) linked to mutations of the C9ORF72 gene.

8 Jan 2018

Strategies to prevent and treat acute chest syndrome in children with sickle cell disease

Acute chest syndrome (ACS), a potentially severe lung complication of sickle cell disease, increases a child's risk of respiratory failure, chronic lung disease, and prolonged hospitalization if not recognized early and treated effectively.

5 Jan 2018

Sickle cell patients, families and doctors face a ‘fight for everything’

The day before his 30th birthday, Marqus Valentine was in a panic. "I was so scared for midnight to come rolling around because subconsciously I was like, 'This is it. Tomorrow’s my last day on Earth,'" he said.

27 Dec 2017

Researchers find link between negative emotions and higher opioid use in people with sickle cell disease

In a small study using data from daily electronic patient diaries, Johns Hopkins researchers say they have found a link between negative emotions, such as sadness and anxiety, and higher opioid use in people with sickle cell disease whose pain levels were self-reported as relatively low.

27 Nov 2017

Increasing hydroxyurea dose linked to reduction in hospitalization for young sickle cell anemia patients

St. Jude Children's Research Hospital investigators have shown that using the drug hydroxyurea to boost average fetal hemoglobin levels above 20 percent in children and teenagers with sickle cell anemia was associated with at least a two-fold reduction in hospitalization for any reason.

9 Nov 2017

Sickle Cell Disease News and Research

Latest Sickle Cell Disease News and Research

Regenacy Pharmaceuticals partners with CMTA to advance ricolinostat for treating hereditary neuropathy

Therapy with L-Glutamine reduces pain in patients with sickle cell disease

Researchers identify enzyme as potential new drug target for blood disorders

CRISPR/Cas9 gene editing can cause greater genetic damage than previously thought

New guideline recommends first-trimester screening of pregnant women for asymptomatic bacteriuria

Music therapy shows promise for improving lives of people with sickle cell disease

Acetaminophen use helps reduce acute kidney injury risk in pediatric heart surgery patients

Study: Stigmatizing language in medical records may play a role in how the patient is treated

Doctors cure sickle cell patients using allogeneic stem cells

Pitt researcher secures nearly $5 million NIH funding for 'Tic-Tac-Toe' RF coil system

Using Cord Blood to Alleviate the Symptoms of Autism

Genetic mutation that may protect people from malaria found to be more common

University of Illinois at Chicago awarded $4.6 million NIH grant for chronic pain research

Study reveals HCT as effective treatment for NHL patients regardless of age

Combination chemotherapy increases survival in animal models of glioblastoma

Sangamo and Pfizer partner for development of new zinc finger protein gene therapy to treat ALS

Strategies to prevent and treat acute chest syndrome in children with sickle cell disease

Sickle cell patients, families and doctors face a ‘fight for everything’

Researchers find link between negative emotions and higher opioid use in people with sickle cell disease

Increasing hydroxyurea dose linked to reduction in hospitalization for young sickle cell anemia patients

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

Sickle Cell Disease News and Research

Latest Sickle Cell Disease News and Research

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

Newsletters you may be interested in