Sickle Cell Disease News and Research

Latest Sickle Cell Disease News and Research

Anemia, high blood pressure linked to risk of silent strokes in children with SCD

A team of researchers from the Johns Hopkins Children's Center, Vanderbilt University and elsewhere have demonstrated that high blood pressure and anemia together put children with sickle cell disease (SCD) at serious danger for symptomless or so-called "silent" strokes, although either condition alone also signaled high risk.

30 Nov 2011

CINJ experts available to comment on blood donations

Every two seconds, someone in the United States is in need of blood. According to the American Red Cross, more than 38,000 blood donations are needed each day. With just one donation of a pint of blood, up to three lives can be saved. In New Jersey, according to the state Department of Health and Senior Services, fewer than four percent of eligible residents donate regularly, resulting in the need for critical blood donations.

18 Nov 2011

Hemoglobin levels, blood pressure and male gender linked to higher risk of silent strokes in SCA children

Factors such as low hemoglobin levels, increased systolic blood pressure, and male gender are linked to a higher risk of silent cerebral infarcts (SCIs), or silent strokes, in children with sickle cell anemia (SCA), according to results from a large, first-of-its-kind study published online today in Blood, the Journal of the American Society of Hematology (ASH).

17 Nov 2011

New blood spot analysis method can diagnose range of clinical conditions

Scientists have developed a rapid method that can be used to simultaneously screen patients for a range of genetic and acquired clinical conditions from a single dried blood spot.

17 Nov 2011

Researchers to begin drug development projects for rare and neglected diseases

Researchers will begin drug development projects for rare and neglected diseases that include potential treatments for a musculoskeletal disorder, a cognitive dysfunction disorder, a virus that affects the central nervous system of newborns, a parasitic worm infection, a form of muscular dystrophy and a rare lung disease.

16 Nov 2011

Public health officials should address needs of people with blood disorders

Public health should focus not only on reducing the burden of common diseases but also address the needs of people with blood disorders , experts say in a supplement to December's American Journal of Preventive Medicine.

16 Nov 2011

Cortex third quarter net loss increases to $1,175,000

Cortex Pharmaceuticals, Inc. reported a net loss of approximately $1,175,000, or $0.01 per share, for the quarter ended September 30, 2011, compared with a net loss of approximately $528,000, or $0.01 per share, for the corresponding prior year quarter.

14 Nov 2011

ADVENTRX prices underwritten public offering of common stock

ADVENTRX Pharmaceuticals, Inc. today announced the pricing of an underwritten public offering of 21,250,000 shares of its common stock and warrants exercisable for up to 10,625,000 additional shares at $0.80 per fixed combination of shares and warrants for gross proceeds of approximately $17 million.

11 Nov 2011

Increasing TR2/TR4 expression can lead to higher fetal hemoglobin levels in sickle cell patients

A University of Michigan Health System laboratory study reveals a key trigger for producing normal red blood cells that could lead to a new treatment for those with sickle cell disease.

3 Nov 2011

ApoPharma receives FDA approval for Ferriprox to treat transfusional iron overload

The U.S. Food and Drug Administration today approved Ferriprox (deferiprone) to treat patients with iron overload due to blood transfusions in patients with thalassemia, a genetic blood disorder that causes anemia, who had an inadequate response to prior chelation therapy.

15 Oct 2011

BCL11A protein might serve as potential target for sickle cell disease

Flipping a single molecular switch can reverse illness in a model of sickle cell disease, according to a study by researchers at Children's Hospital Boston and Dana-Farber Cancer Institute. When turned off, the switch, a protein called BCL11A, allows the body to manufacture red blood cells with an alternate form of hemoglobin unaffected by the mutation that causes the disease.

14 Oct 2011

Potential new protein target for sickle cell disease

National Institutes of Health-funded scientists have corrected sickle cell disease in adult laboratory mice by activating production of a special blood component normally produced before, but not after, birth.

14 Oct 2011

Affymetrix launches Axiom Pan-African Array

Affymetrix, Inc. today announced at the ICHG/ASHG annual conference in Montreal, the worldwide launch of the Axiom Genome-Wide Pan-African Array, the first commercial product to maximize genomic coverage of both common and rare alleles in populations of African ancestry, including West African, East African, and African American.

13 Oct 2011

ADVENTRX holds Type A meeting with FDA to discuss Exelbine NDA

ADVENTRX Pharmaceuticals, Inc. announced today that it held a Type A meeting with the U.S. Food and Drug Administration (FDA) to discuss the complete response letter (CRL) it received in August from the FDA regarding the Company's New Drug Application (NDA) for Exelbine (vinorelbine injectable emulsion) for the treatment of non-small cell lung cancer.

1 Oct 2011

Researchers use patient's own stem cells to correct genetic alteration that causes SCD

Using a patient's own stem cells, researchers at Johns Hopkins have corrected the genetic alteration that causes sickle cell disease (SCD), a painful, disabling inherited blood disorder that affects mostly African-Americans. The corrected stem cells were coaxed into immature red blood cells in a test tube that then turned on a normal version of the gene.

29 Sep 2011

Viewpoints: Ron Paul, USA Today on individual mandate; NYT's Greenhouse on court challenges to health law

Massachusetts leads the nation in health insurance coverage of its citizens, and Texas is dead last. You'd think that former Massachusetts governor Mitt Romney would be bragging about his role in making his state No. 1, and that Texas Gov. Rick Perry would be embarrassed by how poorly his state is doing. But that's not how the script is playing out … That's odd, though, because the mandate was born as a conservative response to President Clinton's much maligned health reform proposal.

23 Sep 2011

ODAC recommends ApoPharma's Ferriprox for FDA approval to treat transfusional iron overload

ApoPharma Inc. today announced that the Oncologic Drugs Advisory Committee (ODAC) to the U.S. Food and Drug Administration (FDA) voted 10 - 2 to recommend that the FDA grant accelerated approval of Ferriprox (deferiprone), an oral iron chelator, for the treatment of patients with transfusional iron overload when current chelation therapy is inadequate.

15 Sep 2011

Sickle cell trait does not increase risk of severe kidney disease in African-Americans

Researchers at Wake Forest Baptist Medical Center report that sickle cell trait is not a risk factor for the development of severe kidney disease in African-Americans.

15 Sep 2011

Enrollment complete in HemaQuest HQK-1001 Phase 2 study in sickle cell disease

HemaQuest Pharmaceuticals, Inc., a biotechnology company focused on developing small molecule therapeutics to treat hemoglobin disorders, announced today that it has completed enrollment in a randomized multi-dose Phase 2 study of HQK-1001 in patients with sickle cell disease.

12 Sep 2011

New blood test could help identify babies at risk of sickle cell disease

A new blood test is being developed by researchers in Cambridge and Oxford, which, for the first time, could help identify babies at risk of a severe form of sickle cell disease, allowing immediate and more intensive treatment to be given, thanks to a grant from children's charity Action Medical Research.

7 Sep 2011

Sickle Cell Disease News and Research

Latest Sickle Cell Disease News and Research

Anemia, high blood pressure linked to risk of silent strokes in children with SCD

CINJ experts available to comment on blood donations

Hemoglobin levels, blood pressure and male gender linked to higher risk of silent strokes in SCA children

New blood spot analysis method can diagnose range of clinical conditions

Researchers to begin drug development projects for rare and neglected diseases

Public health officials should address needs of people with blood disorders

Cortex third quarter net loss increases to $1,175,000

ADVENTRX prices underwritten public offering of common stock

Increasing TR2/TR4 expression can lead to higher fetal hemoglobin levels in sickle cell patients

ApoPharma receives FDA approval for Ferriprox to treat transfusional iron overload

BCL11A protein might serve as potential target for sickle cell disease

Potential new protein target for sickle cell disease

Affymetrix launches Axiom Pan-African Array

ADVENTRX holds Type A meeting with FDA to discuss Exelbine NDA

Researchers use patient's own stem cells to correct genetic alteration that causes SCD

Viewpoints: Ron Paul, USA Today on individual mandate; NYT's Greenhouse on court challenges to health law

ODAC recommends ApoPharma's Ferriprox for FDA approval to treat transfusional iron overload

Sickle cell trait does not increase risk of severe kidney disease in African-Americans

Enrollment complete in HemaQuest HQK-1001 Phase 2 study in sickle cell disease

New blood test could help identify babies at risk of sickle cell disease

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

Sickle Cell Disease News and Research

Latest Sickle Cell Disease News and Research

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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