Sickle Cell Disease News and Research

Latest Sickle Cell Disease News and Research

Socioeconomic deprivation linked with increased late mortality in childhood cancer survivors

St. Jude Children's Research Hospital scientists have found that socioeconomic deprivation, the presence of treatable chronic health conditions and frailty are independently associated with increased late mortality in childhood cancer survivors.

10 Feb 2023

Researchers document link between higher risk of maternal mortality and sickle cell disease

Johns Hopkins Medicine researchers have further documented an association between a substantially higher risk of maternal morbidity and mortality among those with the inherited blood disorder sickle cell disease (SCD) compared to those without it.

3 Feb 2023

Bone marrow transplants may prevent blood vessel disease in patients with sickle cell disease

Bone marrow transplants prevented or improved blood vessel disease in the brains of adults with sickle cell disease, according to preliminary research to be presented at the American Stroke Association's International Stroke Conference 2023.

2 Feb 2023

Scientists use next-generation protein degradation technology to study CTCF's role in transcription

CTCF is a critical protein known to play various roles in key biological processes such as transcription. Scientists at St. Jude Children's Research Hospital used a next-generation protein degradation technology to study CTCF.

26 Jan 2023

Cryo-electron microscopy captures the first 3D structure of SPOP protein that drives cancer

SPOP is the most mutated protein in prostate cancer and plays a role in endometrial, uterine and other cancers. Despite this importance, how SPOP mutations drive cancer has been incompletely understood.

23 Jan 2023

10 years of CRISPR genome editing: Advances, limitations, and future potential

In the decade since the publication of CRISPR-Cas9 as a genome editing technology, the CRISPR toolbox and its applications have profoundly changed biological research, enabling advances through applications in plants, animals, and humans.

20 Jan 2023

Study describes the variations in drug response across genetic subtypes of childhood leukemia

Scientists at St. Jude Children's Research Hospital are reporting the most comprehensive study to date describing the variations in drug response across different genetic subtypes of acute lymphoblastic leukemia (ALL).

5 Jan 2023

Mutations responsible for common inherited heart condition corrected using CRISPR-Cas9 therapy

Using the CRISPR-Cas9 gene editing system, UT Southwestern researchers corrected mutations responsible for a common inherited heart condition called dilated cardiomyopathy (DCM) in human cells and a mouse model of the disease.

21 Dec 2022

Cancer patients with sickle cell disease report reduction in pain and anxiety in response to music therapy

A new study from University Hospitals Connor Whole Health found patients with cancer and patients with sickle cell disease (SCD) treated at an academic cancer center reported clinically significant reductions in pain and anxiety in response to music therapy.

19 Dec 2022

For patients with sickle cell disease, fertility care is about reproductive justice

Teonna Woolford has always wanted six kids. Why six? "I don't know where that number came from. I just felt like four wasn't enough," said Woolford, a Baltimore resident. "Six is a good number."

8 Dec 2022

Scientists show how cellular hypoxia response increases fetal hemoglobin expression in adults

Scientists at St. Jude Children's Research Hospital have shown how a protein responsible for adapting to low oxygen conditions (hypoxia), causes increased expression of fetal hemoglobin (HbF) in adults.

12 Oct 2022

Routine newborn screening for sickle cell disease urgently needed to save lives in Africa

More than 300,000 babies globally are born every year with sickle cell, a hereditary condition which causes red blood cells to become sickle-shaped.

5 Oct 2022

Report: Less than half of children with sickle cell anemia received recommended screening and treatment

In 2019, less than half of children aged 2–16 years with sickle cell anemia received the recommended screening for stroke, a common complication of the disease, according to a new CDC Vital Signs report.

27 Sep 2022

Scientists create new tool to identify genomic safe harbor sites in specific tissues

Scientists at St. Jude Children's Research Hospital have created a tool that can find safe places to introduce genes into human DNA.

22 Sep 2022

Six-country African study highlights the potential dangers of getting COVID-19 during pregnancy

A new study involving hospitalized women in six African countries from the University of Maryland School of Medicine's (UMSOM) Institute of Human Virology (IHV) showed that pregnant women with SARS-CoV-2, the virus that causes COVID-19, had double the risk of being admitted to the intensive care unit (ICU) and four-times the risk of dying in-hospital than pregnant women who did not have COVID-19.

19 Jul 2022

Novel gene-based therapies for sickle cell disease rely on finding the right mouse for the job

Sickle cell disease is an extremely debilitating condition that affects up to 40% of the population in African countries, with patients suffering episodes of excruciating pain, organ damage and reduced life-expectancy.

7 Jul 2022

Brigham receives $16 million Helmsley Charitable Trust grant to improve healthcare delivery for NCDs

Brigham and Women's Hospital announces a $16 million grant from The Leona M. and Harry B. Helmsley Charitable Trust to support the implementation and evaluation of an integrated service delivery model (PEN-Plus) for severe chronic noncommunicable diseases (NCDs) such as type 1 diabetes, rheumatic heart disease, cardiomyopathies, and sickle cell disease in eight low- and lower-middle-income countries in sub-Saharan Africa and South Asia.

1 Jul 2022

Sickle Cell Disease News and Research

Latest Sickle Cell Disease News and Research

Socioeconomic deprivation linked with increased late mortality in childhood cancer survivors

Researchers document link between higher risk of maternal mortality and sickle cell disease

Bone marrow transplants may prevent blood vessel disease in patients with sickle cell disease

Scientists use next-generation protein degradation technology to study CTCF's role in transcription

Cryo-electron microscopy captures the first 3D structure of SPOP protein that drives cancer

10 years of CRISPR genome editing: Advances, limitations, and future potential

Study describes the variations in drug response across genetic subtypes of childhood leukemia

Mutations responsible for common inherited heart condition corrected using CRISPR-Cas9 therapy

Cancer patients with sickle cell disease report reduction in pain and anxiety in response to music therapy

For patients with sickle cell disease, fertility care is about reproductive justice

Scientists show how cellular hypoxia response increases fetal hemoglobin expression in adults

Routine newborn screening for sickle cell disease urgently needed to save lives in Africa

Report: Less than half of children with sickle cell anemia received recommended screening and treatment

Scientists create new tool to identify genomic safe harbor sites in specific tissues

Six-country African study highlights the potential dangers of getting COVID-19 during pregnancy

Novel gene-based therapies for sickle cell disease rely on finding the right mouse for the job

Brigham receives $16 million Helmsley Charitable Trust grant to improve healthcare delivery for NCDs

Researchers explore disease severity post-infection with SARS-CoV-2 Omicron in hematologic patients

New Stad Center for Pediatric Pain, Palliative & Integrative Medicine launched with a $3 million gift

Study highlights the economic burden affecting individuals with sickle cell disease

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

Sickle Cell Disease News and Research

Latest Sickle Cell Disease News and Research

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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