Toxicology News and Research

Latest Toxicology News and Research

Study identifies potential noninvasive biomarkers in NAFLD, NASH using Metabolon's platform

Metabolon, Inc. announces a study published in the Metabolism Journal released in the paper on April 28, 2010, by Satish C. Kalhan.

17 May 2010

Caliper Life Sciences' CDAS unit awarded new funding commitment for EPA ToxCast screening program

Caliper Life Sciences, Inc., a leading provider of tools and services for drug discovery and life sciences research, today announced that its Caliper Discovery Alliances and Services (CDAS) unit has been awarded a new funding commitment for $2.9 million under its contract with the Environmental Protection Agency for the EPA's ToxCast screening program.

14 May 2010

EPA continues to validate ToxCast screening tool by testing more than 100 drugs

The U.S. Environmental Protection Agency will continue validating its ToxCast screening tool by screening more than 100 drugs provided by Pfizer, GlaxoSmithKline, Sanofi-Aventis, and Merck. These drugs never entered the marketplace because they demonstrated different types and levels of toxicity when the pharmaceutical companies conducted the early stage clinical trials required by the Food and Drug Administration as part of the drug development process.

14 May 2010

Scientists study impact of Hurricane Katrina on ecology, human health

Scientists studying the environmental impact of Hurricane Katrina on the Gulf Coast of Louisiana and the city of New Orleans have revealed the ecological impact and human health risks from exposure to chemical contaminants. The findings, published in a special issue of Environmental Toxicology and Chemistry, demonstrate how Hurricane Katrina caused significant ecological damage by altering coastal chemistry and habitat.

14 May 2010

Chimerix commences first-in-human study of CMX157 for HIV

Chimerix, Inc., a biotechnology company developing orally-available antiviral therapeutics, announced the commencement of a first-in-human study of CMX157, a novel lipid conjugate of the nucleotide tenofovir with in vitro activity against both tenofovir-sensitive and tenofovir-resistant human immunodeficiency virus (HIV). CMX157 has the potential to increase efficacy and decrease toxicity as compared to tenofovir, and may enable the creation of new 'one pill, once-a-day', fixed-dose combination regimens for the treatment of HIV infection.

14 May 2010

NiKem Research receives Italian authorization to perform toxicology studies of NCEs in rodents

NiKem Research is pleased to announce that it has received on March 29th 2010, from the Italian Ministry of Health (Decree N. 69/2010-B), the authorization to perform acute and sub-chronic toxicology studies (upto 28 days) in all rodent species for preliminary safety evaluation of novel chemical entities (NCEs). Toxicokinetic (TK) studies are also allowed to correlate plasma and/or organ exposure of NCEs (and metabolites) to tolerated doses in toxicology studies.

12 May 2010

Anavex reports promising results from ANAVEX 2-73 Alzheimer's disease compound in animal studies

Anavex Life Sciences Corp. is pleased to report promising results from animal studies with ANAVEX 2-73, the company's lead compound for the treatment and modification of Alzheimer's disease.

5 May 2010

NOXXON Pharma completes first-in-human clinical trial with Spiegelmer NOX-A12

NOXXON Pharma AG, the biopharmaceutical company focusing on the development of novel drugs based on its unique proprietary Spiegelmer® technology, announced today the successful completion of the first-in-human clinical trial with Spiegelmer® NOX-A12.

3 May 2010

Searchable database on chemical hazard, exposure and toxicity data now available

The U.S. Environmental Protection Agency is making it easier to find chemical information online. EPA is releasing a database, called ToxRefDB, which allows scientists and the interested public to search and download thousands of toxicity testing results on hundreds of chemicals.

3 May 2010

NIEHS doctor to discuss impact of climate change on children's health

John Balbus, MD, MPH, Senior Advisor for Public Health at the National Institutes of Environmental Health Sciences (NIEHS), will discuss the significant public health threats and opportunities presented by climate change and how children around the world may be affected.

3 May 2010

CBC, Scarab Genomics form agreement to increase manufacturing yield of Solinex rhu-pGSN

Critical Biologics Corporation (CBC) and Scarab Genomics announced today a strategic agreement to substantially increase the manufacturing yield of CBC's lead therapeutic protein candidate, Solinex™, an intravenous formulation of recombinant human plasma gelsolin (rhu-pGSN).

30 Apr 2010

NWO awards 31 grants in Investment Subsidy NWO Medium programme

The Netherlands Organisation for Scientific Research (NWO) has awarded 31 grants in the Investment Subsidy NWO Medium programme for the acquisition of equipment, the setting up of data collections and the production of software and bibliographies. The total investment amounts to 10 million euro.

30 Apr 2010

Experts discuss recent advancements in personalized medicine for treating childhood disorders

Many of the world's leading experts in pediatric pharmacogenomics and personalized medicine are gathering today at a first-of-its-kind conference in Kansas City to change the way childhood diseases and illnesses are treated.

29 Apr 2010

Fluorescent inhibitors hold promise for early-stage tumor detection

A series of novel imaging agents could light up tumors as they begin to form - before they turn deadly - and signal their transition to aggressive cancers.

29 Apr 2010

A new approach for treating neurological and degenerative disorders

In studies on cancer, heart disease, neurological disorders and other degenerative conditions, some scientists are moving away from the "nature versus nurture" debate, and are finding you're not a creature of either genetics or environment, but both - with enormous implications for a new approach to health.

29 Apr 2010

Lycera to advance discovery, development efforts with second tranche of $11 million Series A financing

Lycera Corporation, a biopharmaceutical company pioneering an innovative approach to developing novel oral medicines to treat autoimmune diseases, today announced that the company has made important progress, triggering a second tranche of $11 million in its Series A financing. Proceeds from the second tranche will be used to continue to advance Lycera's discovery and development efforts and further support the growth of the company.

29 Apr 2010

Dietary MSC can help reset cell's biological clock to prevent development of breast cancer: Study

Usually when all else fails with a technical device, a "reset" button can be pressed, preventing a glitch from going any further. What if that could be done with threats to a person's health? Investigators from The Cancer Institute of New Jersey and the Environmental & Occupational Health Sciences Institute which is jointly administered by UMDNJ-Robert Wood Johnson Medical School and Rutgers, The State University of New Jersey, have discovered that a form of a dietary trace element known as selenium can help reset a cell's "biological clock" when it is disrupted by a chemical cancer-causing agent (carcinogen).

28 Apr 2010

Charles River Laboratories International, WuXi PharmaTech sign definitive agreement to combine

Charles River Laboratories International, Inc., a leading global provider of research models and associated services and of preclinical drug development services, and WuXi PharmaTech, a leading drug research and development outsourcing company with expertise in discovery chemistry and with operations in China and the United States, today announced that they have signed a definitive agreement under which Charles River and WuXi will combine in a cash and stock transaction valued at approximately $1.6 billion.

26 Apr 2010

isrp awarded $16M grant to study health effects of environmental pollutants

The National Institute of Environmental Health Sciences has awarded the University of Iowa Superfund Research Program (isrp) a five-year, $16 million grant to study the health effects of environmental pollutants, especially polychlorinated biphenyls (PCBs) found in water, former industrial sites and the atmosphere.

23 Apr 2010

Report highlights 11 key categories of diseases, health consequences that occur due to climate change

A report released today by a federal working group highlights 11 key categories of diseases and other health consequences that are occurring or will occur due to climate change. The report, A Human Health Perspective on Climate Change, provides a starting point for coordination of federal research to better understand climate's impact on human health.

22 Apr 2010

Toxicology News and Research

Latest Toxicology News and Research

Study identifies potential noninvasive biomarkers in NAFLD, NASH using Metabolon's platform

Caliper Life Sciences' CDAS unit awarded new funding commitment for EPA ToxCast screening program

EPA continues to validate ToxCast screening tool by testing more than 100 drugs

Scientists study impact of Hurricane Katrina on ecology, human health

Chimerix commences first-in-human study of CMX157 for HIV

NiKem Research receives Italian authorization to perform toxicology studies of NCEs in rodents

Anavex reports promising results from ANAVEX 2-73 Alzheimer's disease compound in animal studies

NOXXON Pharma completes first-in-human clinical trial with Spiegelmer NOX-A12

Searchable database on chemical hazard, exposure and toxicity data now available

NIEHS doctor to discuss impact of climate change on children's health

CBC, Scarab Genomics form agreement to increase manufacturing yield of Solinex rhu-pGSN

NWO awards 31 grants in Investment Subsidy NWO Medium programme

Experts discuss recent advancements in personalized medicine for treating childhood disorders

Fluorescent inhibitors hold promise for early-stage tumor detection

A new approach for treating neurological and degenerative disorders

Lycera to advance discovery, development efforts with second tranche of $11 million Series A financing

Dietary MSC can help reset cell's biological clock to prevent development of breast cancer: Study

Charles River Laboratories International, WuXi PharmaTech sign definitive agreement to combine

isrp awarded $16M grant to study health effects of environmental pollutants

Report highlights 11 key categories of diseases, health consequences that occur due to climate change

Forensics And Toxicology eBook

Precision in every drop: Inside Hamilton’s syringe technology

Exploring the Future of Neuroscience Drug Discovery

Genomic conservation in Thailand's mangroves

Toxicology News and Research

Latest Toxicology News and Research

Forensics And Toxicology eBook

Precision in every drop: Inside Hamilton’s syringe technology

Exploring the Future of Neuroscience Drug Discovery

Genomic conservation in Thailand's mangroves

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