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New software tool provides a way for safer design of genome editing

A team of researchers has developed a software tool called DANGER (Deleterious and ANticipatable Guides Evaluated by RNA-sequencing) analysis that provides a way for the safer design of genome editing in all organisms with a transcriptome.

24 Oct 2023

Could the microbiome hold the key to diagnosing and treating biliary tract cancer?

A recent study in "Microorganisms" delves into the relationship between the microbiome and biliary tract cancer, revealing distinct microbial compositions in patients compared to healthy individuals. This research highlights potential diagnostic biomarkers and suggests that altering gut microbial composition might enhance responses to cancer immunotherapy.

24 Oct 2023

Gene therapy breakthrough: Scientists develop method to deliver larger genes to target cells

Gene therapy currently represents the most promising approach for the treatment of hereditary diseases. Yet despite significant breakthroughs in recent years, there are still a number of hurdles that hinder the wider application of gene therapies.

24 Oct 2023

Plant microorganisms from fruit and vegetables boost gut diversity

Bacterial diversity in the gut plays an important role in human health. The crucial question, however, is where are the sources of this diversity? It is known that an important part of the maternal microbiome is transferred to the baby at birth, and the same happens during the breastfeeding period via breast milk.

24 Oct 2023

Researchers discover new way to trigger programmed cell death in cancer cells

A research team from the UC Davis Comprehensive Cancer Center has identified a crucial epitope (a protein section that can activate the larger protein) on the CD95 receptor that can cause cells to die.

24 Oct 2023

Study reveals an alternate origin of brain mosaicism in some children with focal epilepsy

In most people, every cell in their body contains the same genetic information. However, sometimes people can have two or more genetically different sets of cells.

24 Oct 2023

Revolutionary approach links protein analysis and single-cell study to uncover disease mechanisms

Integrated liquid-biopsy proteomics with single-cell transcriptomics from ocular cell types.

24 Oct 2023

Genomic surveillance could help detect and slow the spread of deadly 'superbugs'

Harnessing new advances in genomic surveillance technology could help detect the rise of deadly 'superbugs' and slow their evolution and spread, improving global health outcomes, a new Australian study suggests.

24 Oct 2023

Apoptotic cells play key role in hair follicle regression

A new research paper was published in Oncotarget's Volume 14 on October 19, 2023, entitled, "Apoptotic cells may drive cell death in hair follicles during their regression cycle."

24 Oct 2023

DeNovix CellDrop Becomes First ACT® Label Certified Automated Cell Counter

The DeNovix CellDrop™ Automated Cell Counter has achieved ACT® Label certification from My Green Lab®, making it the first automated cell counter accredited by the program.

From DeNovix Inc. 23 Oct 2023

Ketamine's long-lasting antidepressant effects unveiled in new study

Persistent blocking of NMDAR and burst-type firing by lateral habenula (LHb) neurons may offer a basis for the long-lasting antidepressant effects of ketamine.

22 Oct 2023

How chromatin compartmentalization affects DNA damage response

Researchers uncover novel insights into how chromatin compartmentalization influences the DNA damage response (DDR) after double-stranded breaks (DSBs), shedding light on the mechanisms behind genomic integrity maintenance and the risk of translocations. Their findings reveal the importance of chromosomal design in DNA repair and the potential implications for genome stability and cancer translocations.

22 Oct 2023

New method uses magnets to align muscle cells

Stimulating muscle fibers with magnets causes them to grow in the same direction, aligning muscle cells within tissue, Massachusetts Institute of Technology (MIT) and Boston University investigators report October 20 in the journal Device.

20 Oct 2023

Cockroaches provide clues to understanding immune system during pregnancy

Researchers are studying the dramatic physical transformation that some insects undergo to give birth to live young.

20 Oct 2023

The emotional dynamics of memory

Researchers investigate how emotional dynamics transform experiences into memorable events.

20 Oct 2023

Are ecological and evolutionary shifts in highly pathogenic avian influenza pointing to another pandemic threat?

Researchers report significant changes in the ecology and evolution of highly pathogenic avian influenza H5 viruses.

20 Oct 2023

Plant geneticists explore predictability of natural and CRISPR mutations

For tens of thousands of years, evolution shaped tomatoes through natural mutations. Then, humans came along. For centuries, we've bred and cherry-picked tomatoes with our preferred traits.

19 Oct 2023

Stanford Medicine researchers find new way to measure ocular aging

Using a technique they developed for studying eye fluid, Stanford Medicine researchers and their collaborators have found a way to measure ocular aging, opening avenues for treatment of numerous eye diseases.

19 Oct 2023

MuTaLig: A multi-target paradigm for innovative drug discoveries

Everyone at some point in their life may need to take medication to treat an illness or disease. By finding new and better ways to create drugs, the COST Action Multi-target paradigm for innovative ligand identification in the drug discovery process (MuTaLig) helped improve the effectiveness and safety of the medications, which can ultimately benefit people's health and well-being.

19 Oct 2023

Study sheds light on genetic architecture of postpartum depression

Postpartum depression (PPD), a common subtype of major depressive disorder, is more heritable than other psychiatric conditions, yet the genetics of PPD are understudied compared to these other psychiatric conditions., such as anxiety and bipolar disorder.

19 Oct 2023