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Severity of COVID-19 in men may be due to the loss of Y chromosome

Men are at an increased risk of a severe bout of COVID-19 compared to women. Researchers at Uppsala University have now shown that this may be due to loss of the Y chromosome in part of their white blood cells.

14 Dec 2022

Research maps the evolution and natural selection of E. coli bacteria

Antibiotic resistance, when infection-causing bacteria evolve so they are no longer affected by typical antibiotics, is a global concern.

14 Dec 2022

Expansion of intermediate cells in prostate cancer correlates with treatment resistance and poor outcomes

Researchers have characterised prostate cancer cell dynamics at a single-cell resolution across the timespan of the disease – from its beginning to the point of androgen independence, where the tumour no longer responds to hormone deprivation therapy.

14 Dec 2022

NIH's All of Us Research Program begins returning personalized health-related DNA results to participants

The National Institutes of Health's All of Us Research Program has begun returning personalized health-related DNA results to more than 155,000 participants, with reports detailing whether participants have an increased risk for specific health conditions and how their body might process certain medications.

13 Dec 2022

Specific bacteria in the bladder may indicate who is more prone to recurrent UTIs

Researchers at The University of Texas at Dallas have identified specific bacteria in the bladder that may indicate which postmenopausal women are more susceptible to recurrent urinary tract infections (UTIs), and they found that estrogen may play a role in reducing that susceptibility.

13 Dec 2022

'Cellular glue' opens the door to building tissues and organs

Researchers at UC San Francisco have engineered molecules that act like "cellular glue," allowing them to direct in precise fashion how cells bond with each other.

13 Dec 2022

Scientists identify molecules in mucus that can block cholera infection

MIT researchers have identified molecules found in mucus that can block cholera infection by interfering with the genes that cause the microbe to switch into a harmful state.

13 Dec 2022

Report makes recommendations clarifying the ethics and oversight of chimeric research

A new report on the ethics of crossing species boundaries by inserting human cells into nonhuman animals – research surrounded by debate – makes recommendations clarifying the ethical issues and calling for improved oversight of this work.

13 Dec 2022

RNA-targeting CRISPR technology alleviates disease-related phenotypes in Huntington’s models

Huntington's disease (HD) is a neurological disorder that causes progressive loss of movement, coordination and cognitive function.

12 Dec 2022

Nanomaterial can indirectly affect the immune system via the gut microbiome, study shows

The nanomaterial graphene oxide-;which is used in everything from electronics to sensors for biomolecules-;can indirectly affect the immune system via the gut microbiome, as shown in a new study on zebrafish by researchers at Karolinska Institutet in Sweden.

12 Dec 2022

CRISPR/Cas9-engineered avatar mouse model of rare disease paves the way for targeted therapy

An international research team led by Dr Ana Guadaño at the Alberto Sols Biomedical Research Institute (IIBM, a combined CSIC-UAM center) and involving the Complutense University of Madrid (UCM), used CRISPR gene editing techniques to incorporate into the mice a mutation of the MCT8 protein responsible for transporting thyroid hormones to the interior of the cell.

12 Dec 2022

New computer model can help researchers to spot which cells acquire alterations during development

Scientists at Johns Hopkins Medicine say they have developed a computer model -; dubbed quantitative fate mapping -; that looks back in the developmental timeline to trace the origin of cells in a fully grown organism

12 Dec 2022

Researchers develop new porous material capable of regenerating bones and preventing infections

Researchers from the Bioengineering and Biomaterials Laboratory of Universidad Católica de Valencia (UCV) have developed a new porous material capable of regenerating bones and preventing infections at the same time.

12 Dec 2022

Scientists use single-cell multi-omics data to map disease regulatory circuits

Researchers apply MAGICAL for the identification of modulated host response regulatory circuits in response to Staphylococcus aureus.

12 Dec 2022

How human cell atlases provide the missing links between genes, diseases and therapies

A Nature Medicine journal perspective article describes the potential of cell atlases in shaping the future of medicine. Providing the missing link between genes and diseases, single-cell atlases make it possible to develop more precise and specific diagnostic tools by understanding the mechanisms of complex diseases.

12 Dec 2022

Life Science News

Severity of COVID-19 in men may be due to the loss of Y chromosome

Research maps the evolution and natural selection of E. coli bacteria

Expansion of intermediate cells in prostate cancer correlates with treatment resistance and poor outcomes

NIH's All of Us Research Program begins returning personalized health-related DNA results to participants

Specific bacteria in the bladder may indicate who is more prone to recurrent UTIs

'Cellular glue' opens the door to building tissues and organs

Scientists identify molecules in mucus that can block cholera infection

Report makes recommendations clarifying the ethics and oversight of chimeric research

RNA-targeting CRISPR technology alleviates disease-related phenotypes in Huntington’s models

Nanomaterial can indirectly affect the immune system via the gut microbiome, study shows

CRISPR/Cas9-engineered avatar mouse model of rare disease paves the way for targeted therapy

New computer model can help researchers to spot which cells acquire alterations during development

Researchers develop new porous material capable of regenerating bones and preventing infections

Scientists use single-cell multi-omics data to map disease regulatory circuits

How human cell atlases provide the missing links between genes, diseases and therapies

Study provides new insights for the future development of oral insulin pill

Severe COVID-19 causes aging-like changes in the human brain

How convergent evolution is creating new COVID-19 waves

SARS-CoV-1 and SARS-CoV-2 spike proteins utilize different mechanisms to bind to ACE2

Structural studies pave the way for cancer drugs that could target only mutated versions

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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