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Predicting H5N1 disease severity based on T cell responses

New research led by scientists at La Jolla Institute for Immunology (LJI) suggests that many people already have immune cells on "stand by" to fight the H5N1 virus, also known as highly pathogenic avian influenza.

2 Jan 2025

Study identifies novel IgAN loci through pleiotropy

IgA nephropathy (IgAN) is a prevalent form of primary glomerulonephritis characterized by the deposition of IgA in the glomerular mesangium, leading to a spectrum of histopathological lesions and a variable clinical course that can progress to end-stage renal disease in a significant proportion of patients.

2 Jan 2025

Study provides new insights into the genetic underpinnings of pediatric cancers

Largescale changes in the genome inherited from parents are significant risk factors for pediatric solid tumors, such as Ewing sarcoma, neuroblastoma, and osteosarcoma, according to a new study.

2 Jan 2025

Breakthrough in immunology: AbMAP’s novel approach to antibody modeling

Researchers developed AbMAP, a cutting-edge framework leveraging transfer learning to model antibody hypervariable regions, significantly improving design and immune repertoire analysis.

2 Jan 2025

Scientists launch public resource to classify cancer subtypes for better diagnosis

A multi-institutional team of scientists has developed a free, publicly accessible resource to aid in classification of patient tumor samples based on distinct molecular features identified by The Cancer Genome Atlas (TCGA) Network.

2 Jan 2025

Insilico Medicine nominates ISM1745 as preclinical candidate for MTAP-deleted cancers

Insilico Medicine ('Insilico'), a clinical-stage generative artificial intelligence (AI)-driven drug discovery and development company, today announced the nomination of ISM1745, a potentially best-in-class MTA cooperative PRMT5 inhibitor with AI-powered novel scaffold, as preclinical candidate (PCC) for the treatment of MTAP-deleted cancers.

2 Jan 2025

Researchers develop tool to measure biological age in individual cell types

A new priority research paper, featured as the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 22, was published on December 29, 2024. The paper is titled "Cell-type specific epigenetic clocks to quantify biological age at cell-type resolution."

2 Jan 2025

Research reveals key to understanding kidney cancer treatment variability

Fighting cancer can seem like a deadly game of chance. While some patients may respond well to certain treatments, others might not be as fortunate.

2 Jan 2025

New protein offers hope for heart regeneration

Researchers from the Bakkers group at the Hubrecht Institute have successfully repaired damaged mouse hearts using a protein from zebrafish.

2 Jan 2025

Brain mapping reveals cell-specific aging patterns

Based on new brain mapping research funded by the National Institutes of Health (NIH), scientists have discovered that not all cell types in the brain age in the same way.

1 Jan 2025

Unraveling retrotransposon mechanisms in centromere insertion

A joint research group team led by Sayuri Tsukahara and Tetsuji Kakutani of the University of Tokyo has clarified a mechanism of how retrotransposons, genetic elements that can "jump around" chromosomes and are known drivers of evolution, preferentially insert in the centromere.

1 Jan 2025

Machine learning reveals how metabolite profiles predict aging and health

Researchers developed metabolomic aging clocks using machine learning, uncovering links between metabolite profiles, health outcomes, and lifespan.

1 Jan 2025

Advancing Raman microscopy for high-resolution imaging of biological samples

Understanding the behavior of the molecules and cells that make up our bodies is critical for the advancement of medicine.

30 Dec 2024

Novel tool holds great promise for studying mitochondrial calcium signaling

Mitochondrial calcium signaling is crucial for energy metabolism and calcium homeostasis, but monitoring it accurately is challenging due to pH fluctuations.

27 Dec 2024

Mapping cerebellar nuclei outputs in an autism mouse model

The cerebellum plays a critical role in both motor and non-motor functions, and its dysfunction is linked to various mental disorders, including autism.

27 Dec 2024

Freezing Point Osmometry in Life Science Applications

Osmometry is a method to determine a sample´s osmolality. This is the total number of osmotically active particles solved in a solution. These particles influence the colligative properties of the solution, which include the boiling and freezing point but also the vapor pressure for instance.

From KNAUER Wissenschaftliche Geräte GmbH 27 Dec 2024

New strategy revolutionizes glycoproteomics research

Protein glycosylation is a fundamental biological process that regulates various cellular functions, yet its study has been hampered by the complexity and low abundance of glycoproteins.

26 Dec 2024

Advancements in DNA storage through epi-bit technology

In the era of big data, global mass data flow has presented data storage systems with a looming challenge. As DNA has incredibly high storage density – a single gram of DNA can store 215,000 terabytes, the same size as 10 million hours of high-definition video (Imburgia & Nivala, 2024)– and long-term stability, it is an attractive medium for data storage.

26 Dec 2024

Trans-isomerization of unsaturated fatty acids in cooking with sulfur-rich vegetables

Trans-fatty acids (TFA) are a major cause of cardiovascular diseases. These harmful fats can accumulate along artery walls, restricting blood flow and increasing the risk of heart attacks.

26 Dec 2024